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Comprehensive Analysis of 5-Chlorothiophene-2-sulfonic acid tert-butylamide (CAS No. 155731-14-9): Properties, Applications, and Industry Insights

The chemical compound 5-Chlorothiophene-2-sulfonic acid tert-butylamide (CAS No. 155731-14-9) is a specialized sulfonamide derivative with a unique molecular structure combining a thiophene ring and a tert-butylamide group. This compound has garnered significant attention in pharmaceutical and agrochemical research due to its potential as a building block for bioactive molecules. Its chlorothiophene core provides distinct electronic properties, making it valuable for designing heterocyclic compounds with tailored functionalities.

In recent years, the demand for sulfur-containing heterocycles like 5-Chlorothiophene-2-sulfonic acid tert-butylamide has surged, driven by their applications in drug discovery and material science. Researchers frequently search for "thiophene derivatives in medicinal chemistry" or "sulfonamide synthesis methods," reflecting the compound's relevance in modern synthetic workflows. Its CAS No. 155731-14-9 serves as a critical identifier for procurement and regulatory documentation.

The compound's physicochemical properties include moderate solubility in polar organic solvents, a characteristic melting point range, and stability under standard storage conditions. These traits make it suitable for multi-step organic synthesis, particularly in constructing biaryl ethers or enzyme inhibitors. Industry professionals often inquire about "scale-up procedures for chlorothiophene intermediates" or "tert-butylamide protecting group strategies," highlighting its practical utility.

Emerging trends in green chemistry have prompted investigations into eco-friendly synthesis routes for 5-Chlorothiophene-2-sulfonic acid tert-butylamide. Questions like "catalytic approaches to sulfonamide formation" dominate academic discussions, aligning with the global push for sustainable manufacturing. The compound's molecular weight and logP value also make it a candidate for computational chemistry studies, particularly in QSAR modeling.

From a commercial perspective, suppliers emphasize the compound's role as a high-purity intermediate. Analytical techniques such as HPLC and NMR are routinely employed to verify its structural integrity, addressing common customer queries about "certification of thiophene-based chemicals." The tert-butylamide moiety's steric bulk contributes to selective reactivity patterns, a feature exploited in asymmetric synthesis protocols.

Ongoing research explores the compound's potential in electronic materials, where its conjugated system could enable applications in organic semiconductors. This interdisciplinary angle responds to frequent searches about "thiophene units in OLED materials." Regulatory databases list CAS 155731-14-9 with standard handling guidelines, ensuring compliance with international laboratory safety standards.

In conclusion, 5-Chlorothiophene-2-sulfonic acid tert-butylamide represents a versatile chemical entity bridging multiple scientific domains. Its continued prominence in patent literature and custom synthesis requests underscores its importance as a research enabler across academic and industrial settings.

• 358666-45-2(N-Ethylthiophene-2-sulfonamide)
• 100342-30-1(N-Tert-Butyl-2-thiophenesulfonamide)
• 140938-42-7(2-Thiophenesulfonamide, 5-chloro-N-(1-methylethyl)-)
• 497862-56-3(2-Thiophenesulfonamide,5-chloro-N-[(1R,6R,9R)-1-cyanobicyclo[4.2.1]non-9-yl]-, rel-)
• 332354-67-3(N-Isopropylthiophene-2-sulfonamide)
• 522597-87-1(2-Thiophenesulfonamide, 5-chloro-N-[(4-chlorophenyl)methyl]-)
• 750607-94-4(1-(5-Chlorothien-2-yl)sulfonylpiperazine)
• 140938-41-6(2-Thiophenesulfonamide, 5-chloro-N-2-propynyl-)
• 497862-51-8(2-Thiophenesulfonamide,5-chloro-N-[(1R,6R,9R)-1-(hydroxymethyl)bicyclo[4.2.1]non-9-yl]-, rel-)
• 618392-62-4(N-Cyclopropylthiophene-2-sulfonamide)