Cas no 155716-06-6 (Okadaic Acid Ammonium Salt)

Okadaic Acid Ammonium Salt is a potent inhibitor of protein phosphatases PP1 and PP2A, widely utilized in biochemical and pharmacological research. Its ammonium salt form enhances solubility in aqueous solutions, facilitating experimental applications. This compound is particularly valuable for studying cellular signaling pathways, as it induces hyperphosphorylation of proteins by blocking dephosphorylation. It serves as a critical tool in investigations of tumor promotion, apoptosis, and neurodegenerative diseases. The high purity and stability of Okadaic Acid Ammonium Salt ensure reliable and reproducible results in both in vitro and cell-based assays. Its specificity for PP2A makes it indispensable for mechanistic studies in phosphatase-related research.
Okadaic Acid Ammonium Salt structure
Okadaic Acid Ammonium Salt structure
Product Name:Okadaic Acid Ammonium Salt
CAS No:155716-06-6
MF:C44H71NO13
MW:822.033455133438
CID:138761
PubChem ID:24898053
Update Time:2025-11-02

Okadaic Acid Ammonium Salt Chemical and Physical Properties

Names and Identifiers

    • 1,7-Dioxaspiro[5.5]undec-10-ene-2-propanoicacid, a,5-dihydroxy-a,2,10-trimethyl-8-[1-methyl-3-[octahydro-8'-hydroxy-6'-[1-hydroxy-3-(3-methyl-2,8-dioxaspiro[5.5]undec-4-yl)butyl]-5-methyl-7'-methylenespiro[furan-2(3H),2'(3'H)-pyrano[3,2-b]pyran]-5-yl]-2-propen-1-yl]-,ammonium salt (1:1)
    • 1,7-Dioxaspiro[5.5]undec-10-ene-2-propanoicacid, a,5-dihydroxy-a,2,10-trimethyl-8-[1-methyl-3-...
    • Okadaic acid . ammonium salt(high purity)
    • Okadaic acid ammonium salt from Prorocentrum concavum
    • Okadaic Acid, Ammonium Salt
    • HALOCHONDRINE A
    • OKADAIC ACID AMMONIUM
    • OKADAIC ACID AMMONIUM SALT (HIGH PURITY)
    • 9,10-DEEPITHIO-9,10-DIDEHYDROACANTHIFOLICIN
    • 9,10-DEEPITHIO-9,10-DIDEHYDROACANTHIOFOLICIN
    • OKADAIC ACID AMMONIUM FROM PROROCENTRUM CONCAVUM
    • OKADAIC ACID AMMONIUM SALT, PROROCENTRUM CONCAVUM
    • OA
    • Ok
    • OKADAIC ACID AMMONIUM SALT
    • DTXSID40585245
    • Okadaic acid ammonium salt from Prorocentrum concavum, >=90% (HPLC), solid
    • Azanium;(2R)-3-[(2S,6R,8S,11R)-2-[(E,2R)-4-[(2S,2'R,4R,4aS,6R)-4-hydroxy-2-[(1S,3S)-1-hydroxy-3-[(3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-11-hydroxy-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-hydroxy-2-methylpropanoate
    • J-009218
    • PUBCHEM_16219809
    • 155716-06-6
    • Okadaic Acid Ammonium Salt
    • MDL: MFCD00153856
    • Inchi: 1S/C44H68O13.H3N/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42;/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49);1H3/b10-9+;/t26-,27-,28+,30+,31+,32+,33?,34+,35-,36-,37?,38+,39-,41-,42+,43-,44-;/m1./s1
    • InChI Key: ZBOMSHVRJSJGNR-JBNKPAQWSA-N
    • SMILES: O1[C@H]2[C@@H](C(=C)[C@@H]([C@H](C[C@H](C)C3[C@H](C)CC[C@]4(CCCCO4)O3)O)OC2CC[C@]21CC[C@H](/C=C/[C@@H](C)[C@@H]1CC(C)=C[C@]3([C@@H](CC[C@@H](C[C@@](C(=O)[O-])(C)O)O3)O)O1)O2)O.[NH4+]

Computed Properties

  • Exact Mass: 821.49300
  • Monoisotopic Mass: 821.49254132g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 5
  • Hydrogen Bond Acceptor Count: 13
  • Heavy Atom Count: 58
  • Rotatable Bond Count: 9
  • Complexity: 1510
  • Covalently-Bonded Unit Count: 2
  • Defined Atom Stereocenter Count: 15
  • Undefined Atom Stereocenter Count : 2
  • Defined Bond Stereocenter Count: 1
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: nothing
  • Topological Polar Surface Area: 187?2

Experimental Properties

  • Color/Form: White to grayish white solid
  • Boiling Point: 947.3°C at 760 mmHg
  • Flash Point: 526.7°C
  • Solubility: H2O: 0.1?mg/mL
  • PSA: 185.66000
  • LogP: 4.25510
  • Solubility: Insoluble in water

Okadaic Acid Ammonium Salt Security Information

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Additional information on Okadaic Acid Ammonium Salt

Comprehensive Guide to Okadaic Acid Ammonium Salt (CAS No. 155716-06-6): Properties, Applications, and Research Insights

Okadaic Acid Ammonium Salt (CAS No. 155716-06-6) is a derivative of the naturally occurring okadaic acid, a potent phosphatase inhibitor. This compound has garnered significant attention in biochemical and pharmacological research due to its unique properties and wide-ranging applications. In this article, we delve into the chemical characteristics, mechanisms of action, and cutting-edge uses of Okadaic Acid Ammonium Salt, while also addressing common queries and trending topics in the scientific community.

The molecular structure of Okadaic Acid Ammonium Salt includes an ammonium group, which enhances its solubility in aqueous solutions compared to the parent compound. This modification makes it particularly valuable for laboratory applications where water solubility is critical. Researchers often utilize this compound to study cellular signaling pathways, especially those involving protein phosphatases. The okadaic acid ammonium salt mechanism is a hot topic in molecular biology, as it provides insights into diseases like cancer and neurodegenerative disorders.

One of the most frequently searched questions about Okadaic Acid Ammonium Salt is its role in protein phosphatase inhibition. This compound selectively inhibits PP1 and PP2A phosphatases, making it a powerful tool for studying phosphorylation-dependent processes. Recent studies have explored its potential in cancer research, where aberrant phosphorylation is a hallmark of tumor progression. The ability of Okadaic Acid Ammonium Salt to modulate these pathways has sparked interest in its therapeutic applications, though further research is needed to evaluate its safety and efficacy.

Another trending area of interest is the use of Okadaic Acid Ammonium Salt in neurodegenerative disease research. Scientists are investigating how phosphatase inhibition affects tau protein phosphorylation, a key factor in Alzheimer's disease. This aligns with the growing demand for Alzheimer's research tools in the biotech industry. The compound's specificity and potency make it a valuable reagent for modeling disease mechanisms in vitro.

From a technical standpoint, researchers often inquire about the storage and handling of Okadaic Acid Ammonium Salt. Proper storage at -20°C in a dry environment is recommended to maintain its stability. The compound's molecular weight (approximately 828.9 g/mol) and solubility profile are also critical parameters for experimental design. These details are frequently searched by lab technicians and students preparing protocols.

The market for Okadaic Acid Ammonium Salt has expanded in recent years, driven by its applications in cell signaling studies and drug discovery. Suppliers often highlight its high purity (≥95%) and consistency, which are essential for reproducible research. As the demand for phosphatase inhibitors grows, this compound remains a staple in many research laboratories worldwide.

In summary, Okadaic Acid Ammonium Salt (CAS No. 155716-06-6) is a versatile tool in biochemical research, with applications spanning from cancer biology to neuroscience. Its unique properties and mechanisms continue to make it a subject of intense study, addressing some of the most pressing questions in modern science. Whether you're investigating cell cycle regulation or exploring neurodegenerative pathways, this compound offers invaluable insights for advancing your research.

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