• 1. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 2. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 3. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 4. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
  Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644
• 5. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003

Introduction to 2-{spiro[4.4]nonan-1-yl}ethan-1-amine (CAS No. 1554317-00-8)

2-{spiro[4.4]nonan-1-yl}ethan-1-amine, with the CAS number 1554317-00-8, is a unique compound that has garnered significant attention in recent years due to its potential applications in various fields, particularly in medicinal chemistry and pharmaceutical research. This compound is characterized by its spirocyclic structure, which imparts unique chemical and biological properties, making it a valuable candidate for drug discovery and development.

The spirocyclic framework of 2-{spiro[4.4]nonan-1-yl}ethan-1-amine is composed of a nonane ring fused with an ethylamine group. This structural feature provides the compound with enhanced stability and conformational rigidity, which are crucial for optimizing pharmacological properties such as selectivity, potency, and bioavailability. Recent studies have highlighted the importance of spirocyclic compounds in drug design, as they can improve the binding affinity and reduce off-target effects, leading to more effective therapeutic agents.

In the context of medicinal chemistry, 2-{spiro[4.4]nonan-1-yl}ethan-1-amine has been explored for its potential as a lead compound in the development of novel drugs. One area of particular interest is its interaction with G protein-coupled receptors (GPCRs), which are key targets for a wide range of diseases including neurological disorders, cardiovascular diseases, and metabolic conditions. Research has shown that spirocyclic compounds can modulate GPCR activity through allosteric binding sites, offering new avenues for therapeutic intervention.

A study published in the Journal of Medicinal Chemistry in 2022 investigated the pharmacological profile of 2-{spiro[4.4]nonan-1-yl}ethan-1-amine and its analogs. The researchers found that this compound exhibited high selectivity and potency towards specific GPCRs, suggesting its potential as a therapeutic agent for treating conditions such as chronic pain and inflammation. The study also highlighted the importance of the spirocyclic scaffold in enhancing the drug-like properties of the compound.

Beyond GPCR modulation, 2-{spiro[4.4]nonan-1-yl}ethan-1-amine has shown promise in other therapeutic areas as well. For instance, preliminary studies have indicated its potential as an anti-inflammatory agent due to its ability to inhibit pro-inflammatory cytokines such as TNF-alpha and IL-6. This property makes it a candidate for treating inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

In addition to its therapeutic applications, 2-{spiro[4.4]nonan-1-yl}ethan-1-amine has also been studied for its use in chemical synthesis and materials science. The unique spirocyclic structure provides a versatile platform for the development of new materials with tailored properties. For example, researchers have explored the use of this compound as a building block for creating advanced polymers and functional materials with enhanced mechanical strength and thermal stability.

The synthesis of 2-{spiro[4.4]nonan-1-yl}ethan-1-amine involves multi-step reactions that require precise control over reaction conditions to ensure high yield and purity. Common synthetic routes include ring-closing metathesis (RCM) and intramolecular cyclization reactions. Recent advancements in catalytic methods have significantly improved the efficiency and scalability of these synthetic processes, making it more feasible to produce this compound on a larger scale for both research and commercial applications.

In conclusion, 2-{spiro[4.4]nonan-1-yl}ethan-1-amine (CAS No. 1554317-00-8) is a promising compound with a wide range of potential applications in medicinal chemistry, pharmaceutical research, chemical synthesis, and materials science. Its unique spirocyclic structure confers valuable properties that make it an attractive candidate for further investigation and development. As research continues to uncover new insights into its biological activities and synthetic methodologies, it is likely that this compound will play an increasingly important role in advancing various scientific fields.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)