• 1. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 2. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 3. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 4. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 5. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

Methyl 6-(trifluoromethyl)picolinate (CAS No. 155377-05-2): A Comprehensive Overview in Modern Chemical Biology

Methyl 6-(trifluoromethyl)picolinate, a compound with the chemical identifier CAS No. 155377-05-2, has garnered significant attention in the field of chemical biology due to its unique structural and functional properties. This compound, characterized by a trifluoromethyl group attached to a picolinic acid derivative, exhibits promising applications in pharmaceutical research and drug development. The introduction of the trifluoromethyl group, a well-known pharmacophore, enhances the metabolic stability and binding affinity of the molecule, making it an attractive candidate for further exploration.

The structural motif of Methyl 6-(trifluoromethyl)picolinate consists of a pyridine ring substituted with a carboxylate group and a trifluoromethyl moiety at the sixth position. This configuration imparts distinct electronic and steric properties to the molecule, which are critical for its biological activity. The trifluoromethyl group, in particular, is known to increase lipophilicity and reduce metabolic degradation, thereby prolonging the half-life of drugs containing this moiety.

In recent years, there has been a surge in research focusing on the development of novel therapeutic agents that incorporate fluorinated aromatic compounds. Methyl 6-(trifluoromethyl)picolinate has emerged as a key intermediate in the synthesis of various bioactive molecules. Its role as a precursor in the preparation of more complex derivatives has been extensively studied, particularly in the context of antimicrobial and anti-inflammatory agents.

One of the most compelling aspects of Methyl 6-(trifluoromethyl)picolinate is its potential application in oncology research. The trifluoromethyl group has been shown to modulate enzyme activity and receptor binding, making it an effective tool for developing kinase inhibitors and other targeted therapies. Recent studies have demonstrated that derivatives of this compound exhibit inhibitory effects on various cancer-related pathways, suggesting their therapeutic potential in treating solid tumors and hematological malignancies.

The synthesis of Methyl 6-(trifluoromethyl)picolinate involves multi-step organic reactions that require precise control over reaction conditions. Advanced synthetic methodologies, such as palladium-catalyzed cross-coupling reactions and fluorination techniques, have been employed to achieve high yields and purity. These synthetic strategies not only highlight the compound's complexity but also showcase the advancements in synthetic organic chemistry that enable the production of such intricate molecules.

From a pharmacological perspective, Methyl 6-(trifluoromethyl)picolinate has been investigated for its ability to interact with biological targets at both the molecular and cellular levels. Its picolinic acid backbone is known to exhibit interactions with enzymes and receptors involved in metabolic pathways, making it a valuable tool for studying disease mechanisms. Furthermore, its trifluoromethyl substitution enhances its binding affinity to these targets, leading to more potent and selective drug candidates.

The role of computational chemistry in understanding the behavior of Methyl 6-(trifluoromethyl)picolinate cannot be overstated. Molecular modeling techniques have been utilized to predict how this compound interacts with biological targets, providing insights into its mechanism of action. These computational studies have complemented experimental approaches by offering rapid screening of potential drug candidates and optimizing their design for improved efficacy.

Future directions in research on Methyl 6-(trifluoromethyl)picolinate include exploring its derivatives for new therapeutic applications. By modifying different functional groups within its structure, researchers aim to develop compounds with enhanced pharmacological properties. Additionally, investigating its potential as an agrochemical agent is another area of interest, given its structural similarity to certain herbicides and fungicides that exhibit favorable environmental profiles.

The industrial significance of Methyl 6-(trifluoromethyl)picolinate extends beyond academic research. Its synthesis and application have implications for pharmaceutical manufacturing processes, where efficiency and scalability are critical factors. Companies specializing in fine chemicals have developed robust protocols for producing this compound on an industrial scale, ensuring its availability for further development by biotechnology firms.

In conclusion, Methyl 6-(trifluoromethyl)picolinate (CAS No. 155377-05-2) represents a fascinating compound with diverse applications in chemical biology and drug development. Its unique structural features make it a valuable intermediate for synthesizing bioactive molecules with potential therapeutic benefits. As research continues to uncover new applications for this compound, its significance in advancing medical science is likely to grow.

• 131747-42-7(6-(Trifluoromethyl)pyridine-2-carboxylic acid)
• 856868-57-0(1-Isoquinolinecarboxylic acid, 3-(trifluoromethyl)-, ethyl ester)
• 615580-16-0(Ethyl 4,6-bis(trifluoromethyl)-2-pyridinecarboxylate)
• 952182-25-1(methyl 5-(trifluoromethyl)-1H-pyrrole-2-carboxylate)
• 1414887-27-6(ethyl 5-(trifluoromethyl)-1H-pyrrole-2-carboxylate)
• 1209248-98-5(Methyl 6-(fluoromethyl)picolinate)
• 1196145-47-7(Ethyl 4-chloro-6-(trifluoromethyl)picolinate)
• 350602-08-3(Methyl 4-Chloro-6-(trifluoromethyl)picolinate)
• 1010422-92-0(Ethyl 6-(trifluoromethyl)picolinate)
• 1006707-71-6(Methyl 1-(trifluoromethyl)isoquinoline-3-carboxylate)