Cas no 1551650-90-8 (6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one)

6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one is a heterocyclic compound featuring a triazine core substituted with an amino group and a cyclobutyl moiety. Its unique structure makes it a valuable intermediate in pharmaceutical and agrochemical research, particularly in the synthesis of bioactive molecules. The cyclobutyl ring enhances steric and electronic properties, potentially improving binding affinity in target interactions. The amino group offers reactivity for further functionalization, enabling diverse derivatization pathways. This compound is of interest in developing novel inhibitors or modulators due to its balanced lipophilicity and hydrogen-bonding capacity. Its stability under standard conditions ensures reliable handling in synthetic applications.
6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one structure
1551650-90-8 structure
Product Name:6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one
CAS No:1551650-90-8
MF:C7H10N4O
MW:166.180500507355
CID:5263604
Update Time:2025-06-14

6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one Chemical and Physical Properties

Names and Identifiers

    • 6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one
    • Inchi： 1S/C7H10N4O/c8-6-9-5(4-2-1-3-4)10-7(12)11-6/h4H,1-3H2,(H3,8,9,10,11,12)
    • InChI Key： HTXPRUFNVQDORC-UHFFFAOYSA-N
    • SMILES： N1C(N)=NC(C2CCC2)=NC1=O

Experimental Properties

  • Density: 1.72±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
  • Boiling Point: 299.1±23.0 °C(Predicted)
  • pka: 7.22±0.70(Predicted)

6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Enamine
EN300-647043-1.0g
4-AMINO-6-CYCLOBUTYL-2,5-DIHYDRO-1,3,5-TRIAZIN-2-ONE
 1551650-90-8
1.0g
 $1315.0 2023-03-04
Enamine
EN300-647043-2.5g
4-AMINO-6-CYCLOBUTYL-2,5-DIHYDRO-1,3,5-TRIAZIN-2-ONE
 1551650-90-8
2.5g
 $2724.0 2023-03-04
Enamine
EN300-647043-5.0g
4-AMINO-6-CYCLOBUTYL-2,5-DIHYDRO-1,3,5-TRIAZIN-2-ONE
 1551650-90-8
5.0g
 $3450.0 2023-03-04
Enamine
EN300-647043-10.0g
4-AMINO-6-CYCLOBUTYL-2,5-DIHYDRO-1,3,5-TRIAZIN-2-ONE
 1551650-90-8
10.0g
 $4337.0 2023-03-04

6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one Related Literature

Related Categories

Additional information on 6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one

Research Briefing on 6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one (CAS: 1551650-90-8)

6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one (CAS: 1551650-90-8) is a heterocyclic compound that has recently gained attention in the field of chemical biology and medicinal chemistry due to its potential applications in drug discovery and development. This research briefing aims to provide an overview of the latest findings related to this compound, including its synthesis, biological activities, and potential therapeutic applications.

Recent studies have highlighted the unique structural features of 6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one, which make it a promising scaffold for the design of novel bioactive molecules. The compound's cyclobutyl group and triazine core contribute to its stability and ability to interact with various biological targets, including enzymes and receptors involved in disease pathways.

In a 2023 study published in the Journal of Medicinal Chemistry, researchers demonstrated the efficient synthesis of 6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one using a multi-step protocol that optimized yield and purity. The study also explored the compound's inhibitory effects on specific kinases, suggesting its potential as a lead compound for cancer therapy. Further in vitro assays revealed moderate to high activity against several cancer cell lines, with minimal cytotoxicity to normal cells.

Another significant development was reported in a preprint by a team from the University of Cambridge, which investigated the compound's role as a building block for the development of PROTACs (Proteolysis Targeting Chimeras). The researchers successfully conjugated 6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one to E3 ligase ligands, resulting in novel PROTACs capable of degrading target proteins with high specificity. This approach opens new avenues for targeted protein degradation therapies.

Pharmacokinetic studies conducted in animal models have shown that 6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one exhibits favorable absorption and distribution profiles, with good blood-brain barrier penetration in some derivatives. These properties make it particularly interesting for central nervous system (CNS) drug development. However, further optimization is needed to improve metabolic stability and reduce potential off-target effects.

In conclusion, 6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one represents a versatile chemical entity with multiple potential applications in medicinal chemistry. Its unique structure and demonstrated biological activities warrant continued investigation, particularly in the areas of kinase inhibition and targeted protein degradation. Future research should focus on structure-activity relationship studies and the development of more potent and selective derivatives for specific therapeutic indications.

1551650-90-8 (6-Amino-4-cyclobutyl-1,3,5-triazin-2(1H)-one) Related Products

Recommended suppliers
Hubei Cuiyuan Biotechnology Co.,Ltd
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
Hubei Cuiyuan Biotechnology Co.,Ltd
Jiangxi Boyang Pharmaceutical Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Jiangxi Boyang Pharmaceutical Chemical Co., Ltd
Nanjing Jubai Biopharm
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Nanjing Jubai Biopharm
Shaanxi pure crystal photoelectric technology co. LTD
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
Shaanxi pure crystal photoelectric technology co. LTD
Hangzhou TSurgeX Pharmaceutical Technology Co., Ltd.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
Hangzhou TSurgeX Pharmaceutical Technology Co., Ltd.