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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

Comprehensive Overview of 1-(3-bromo-5-chlorophenyl)ethan-1-one (CAS No. 154257-85-9): Properties, Applications, and Industry Relevance

1-(3-bromo-5-chlorophenyl)ethan-1-one, identified by its CAS number 154257-85-9, is a specialized organic compound gaining attention in pharmaceutical and agrochemical research. This halogenated aromatic ketone features a unique molecular structure with both bromo and chloro substituents, making it a valuable intermediate in synthetic chemistry. Recent studies highlight its role in developing novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor scaffolds – a hot topic in cancer therapy research. The compound's electron-withdrawing properties and ring stability contribute to its versatility in cross-coupling reactions, a frequent search query among organic chemists exploring Suzuki-Miyaura couplings.

In the context of green chemistry trends, researchers are investigating eco-friendly synthetic routes for 154257-85-9 to address growing concerns about sustainable manufacturing. Analytical techniques like HPLC purity analysis and LC-MS characterization (commonly searched analytical methods) confirm its high stability under standard storage conditions. The compound's crystallographic data, including its distinctive orthorhombic crystal system, has been documented in several crystallography databases – a detail often requested by material scientists studying molecular packing behaviors.

The pharmaceutical industry particularly values 1-(3-bromo-5-chlorophenyl)ethan-1-one for its role in creating biaryl ether derivatives, a structural motif prevalent in neurological drugs. Recent patent analyses reveal its incorporation in TRPV1 modulator development (a trending pain management target) and JAK-STAT pathway inhibitors. These applications align with current healthcare focus areas like precision medicine and targeted therapies, keywords showing increased search volume in scientific literature databases.

From a regulatory perspective, CAS 154257-85-9 complies with major chemical inventories including TSCA and EINECS, a crucial consideration for manufacturers facing increasing chemical compliance requirements. Its logP value of 2.8 ± 0.3 (predicted) suggests favorable ADME properties for drug development – a key parameter frequently searched by medicinal chemists. The compound's thermal stability up to 200°C makes it suitable for various high-temperature reactions, addressing common processing questions in industrial chemistry forums.

Emerging applications in material science include its use as a precursor for organic semiconductors and photovoltaic materials, connecting to renewable energy research trends. The bromo-chloro substitution pattern enables precise molecular engineering of conjugated systems, a technique gaining traction in OLED development circles. Analytical data shows characteristic NMR peaks at 7.85 ppm (aromatic protons) and 2.65 ppm (acetyl group) – spectral information highly sought after by analytical chemists performing structure elucidation.

Quality control protocols for 1-(3-bromo-5-chlorophenyl)ethan-1-one typically involve GC-MS verification (98.5% purity threshold) and heavy metal screening, meeting stringent ICH guidelines for pharmaceutical intermediates. The compound's molecular weight of 247.5 g/mol and melting point range of 78-81°C are frequently referenced physical properties in technical datasheets. Recent innovations in continuous flow chemistry have demonstrated efficient kilogram-scale production of this intermediate, responding to industry demands for process intensification solutions.

In academic settings, 154257-85-9 serves as an excellent case study for electrophilic aromatic substitution mechanisms and protecting group strategies – fundamental concepts with growing online educational content. Its X-ray diffraction data reveals interesting intermolecular interactions that contribute to crystal lattice stability, a subject of numerous computational chemistry studies. The compound's UV-Vis spectrum shows maximum absorption at 280 nm, information valuable for researchers developing photocatalysts or photoinitiators.

The global market for halogenated acetophenone derivatives like 1-(3-bromo-5-chlorophenyl)ethan-1-one is projected to grow at 6.2% CAGR through 2028, driven by expanding contract research organization activities and generic drug development. Proper storage conditions (recommended: inert atmosphere at 2-8°C) and handling precautions are thoroughly documented in safety data sheets, addressing common workplace safety queries. As research continues, this compound maintains its position as a versatile building block in modern organic synthesis, bridging traditional chemistry with cutting-edge drug discovery and advanced materials innovation.

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