Cas no 154032-37-8 (19-Hydroxycortisol)

19-Hydroxycortisol is a steroid metabolite derived from cortisol, primarily studied for its role in glucocorticoid metabolism and adrenal function. It serves as a key intermediate in the biosynthesis of cortisone and other corticosteroids, offering insights into enzymatic pathways such as 11β-hydroxylase and 21-hydroxylase activity. This compound is of particular interest in endocrine research due to its potential as a biomarker for disorders like congenital adrenal hyperplasia (CAH) and Cushing’s syndrome. Its structural similarity to cortisol allows for applications in studying steroidogenesis and metabolic regulation. Analytical standards of 19-Hydroxycortisol are utilized in LC-MS and immunoassays for precise quantification in clinical and research settings.
19-Hydroxycortisol structure
19-Hydroxycortisol structure
Product Name:19-Hydroxycortisol
CAS No:154032-37-8
MF:C21H30O6
MW:378.459307193756
CID:1059461
PubChem ID:11090178
Update Time:2025-05-20

19-Hydroxycortisol Chemical and Physical Properties

Names and Identifiers

    • 19-Hydroxycortisol
    • Hydrocortisone EP Impurity O
    • Hydrocortisone impurity O (EP)
    • (8S,9S,10S,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10-(hydroxymethyl)-13-methyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
    • SCHEMBL17416921
    • A899301
    • (11beta)-11,17,19,21-Tetrahydroxypregn-4-ene-3,20-dione
    • Pregn-4-ene-3,20-dione, 11,17,19,21-tetrahydroxy-, (11ss)-; Pregn-4-ene-3,20-dione, 11ss,17,19,21-tetrahydroxy- (7CI); (11ss)-11,17,19,21-Tetrahydroxypregn-4-ene-3,20-dione; 19-Hydroxycortisol; Hydrocortisone Imp. O (EP)
    • 154032-37-8
    • Inchi： 1S/C21H30O6/c1-19-9-16(25)18-14(15(19)5-7-21(19,27)17(26)10-22)3-2-12-8-13(24)4-6-20(12,18)11-23/h8,14-16,18,22-23,25,27H,2-7,9-11H2,1H3/t14-,15-,16-,18+,19-,20+,21-/m0/s1
    • InChI Key： VTKZCTNCIDPUEE-UKSDXMLSSA-N
    • SMILES： O[C@]1(C(CO)=O)CC[C@H]2[C@@H]3CCC4=CC(CC[C@]4(CO)[C@H]3[C@H](C[C@@]21C)O)=O

Computed Properties

  • Exact Mass: 378.20423867g/mol
  • Monoisotopic Mass: 378.20423867g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 4
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 27
  • Rotatable Bond Count: 3
  • Complexity: 701
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 7
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.4
  • Topological Polar Surface Area: 115?2

Experimental Properties

  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 619.5±55.0 °C at 760 mmHg
  • Flash Point: 342.4±28.0 °C
  • Vapor Pressure: 0.0±4.1 mmHg at 25°C

19-Hydroxycortisol Security Information

19-Hydroxycortisol Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
H918440-5mg
19-Hydroxycortisol
 154032-37-8
5mg
 $5126.00 2023-05-18
TRC
H918440-10mg
19-Hydroxycortisol
 154032-37-8
10mg
 $6085.00 2023-05-18
TRC
H918440-25mg
19-Hydroxycortisol
 154032-37-8
25mg
 $9225.00 2023-05-18
TRC
H918440-50mg
19-Hydroxycortisol
 154032-37-8
50mg
 $ 11200.00 2023-09-07
SHENG KE LU SI SHENG WU JI SHU
sc-490667-5 mg
19-Hydroxycortisol,
 154032-37-8
5mg
 ￥55,167.00 2023-07-11
SHENG KE LU SI SHENG WU JI SHU
sc-490667-5mg
19-Hydroxycortisol,
 154032-37-8
5mg
 ￥55167.00 2023-09-05

19-Hydroxycortisol Related Literature

Additional information on 19-Hydroxycortisol

Recent Advances in the Study of 19-Hydroxycortisol and Its Implications in Chemical Biology and Medicine

The compound 19-Hydroxycortisol (CAS: 154032-37-8) has recently garnered significant attention in the field of chemical biology and medicine due to its unique biochemical properties and potential therapeutic applications. As a metabolite of cortisol, 19-Hydroxycortisol plays a crucial role in steroidogenesis and has been implicated in various physiological and pathological processes. This research briefing aims to summarize the latest findings related to 19-Hydroxycortisol, focusing on its molecular mechanisms, analytical methodologies, and clinical relevance.

Recent studies have elucidated the enzymatic pathways involved in the biosynthesis of 19-Hydroxycortisol, highlighting its formation via cytochrome P450-mediated hydroxylation of cortisol. Advanced analytical techniques, such as liquid chromatography-tandem mass spectrometry (LC-MS/MS), have been employed to quantify 19-Hydroxycortisol levels in biological samples with high sensitivity and specificity. These methodological advancements have facilitated the investigation of 19-Hydroxycortisol's role in endocrine disorders, including adrenal hyperplasia and Cushing's syndrome.

In addition to its diagnostic utility, 19-Hydroxycortisol has emerged as a potential biomarker for monitoring disease progression and therapeutic response. For instance, elevated levels of 19-Hydroxycortisol have been correlated with the severity of adrenal tumors, suggesting its prognostic value. Furthermore, preclinical studies have explored the therapeutic potential of modulating 19-Hydroxycortisol levels to mitigate glucocorticoid-related adverse effects, such as metabolic syndrome and immune suppression.

The structural and functional characterization of 19-Hydroxycortisol has also paved the way for the development of novel synthetic analogs with enhanced pharmacological profiles. Researchers have employed computational modeling and structure-activity relationship (SAR) studies to design derivatives that selectively target glucocorticoid receptors while minimizing off-target effects. These efforts hold promise for the development of next-generation glucocorticoid therapies with improved safety and efficacy.

Despite these advancements, several challenges remain in the study of 19-Hydroxycortisol. For example, the precise mechanisms underlying its tissue-specific effects and interactions with other steroid hormones are not fully understood. Additionally, the lack of standardized protocols for 19-Hydroxycortisol measurement across laboratories poses a barrier to its widespread clinical adoption. Addressing these gaps will require interdisciplinary collaboration and further validation in large-scale clinical trials.

In conclusion, 19-Hydroxycortisol (154032-37-8) represents a promising area of research in chemical biology and medicine, with implications for both diagnostics and therapeutics. Continued exploration of its molecular pathways and clinical applications will likely yield valuable insights into steroid hormone biology and contribute to the development of innovative treatment strategies for endocrine and metabolic disorders.

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