Cas no 15401-69-1 (Berberrubine chloride)
Berberrubine chloride Chemical and Physical Properties
Names and Identifiers
-
- berberrubine
- 5,6-Dihydro-9-hydroxy-10-methoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride
- 9-Berberoline chloride
- 9-Demethoxy-9-hydroxyberberinium chloride
- Beroline chloride
- Berberrubine Chloride
- 9-Hydroxy-10-methoxy-5,6-dihydro-[1,3]dioxolo-[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chloride
- Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9-hydroxy-10-methoxy-, chloride (1:1)
- BERBERINE
- BERBERRUBINE, HYDROCHLORIDE, DIHYDRATE
- 2,3-methylenedioxy-9-hydroxy-10-methoxyprotoberberine chloride
- beberrubine chloride
- berberoline chloride
- berberrubine hydrochloride
- Berberubine hydrochloride
- Chileninone
- hydrochloride berberrubine
- Nerberrubine
- 9-Hydroxy-10-methoxy-5,6-dihydro-[1,3]dioxolo-[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chlo
- Berberrubine (chloride)
- NSC96347
- Beroline
- 9-Berberoline
- BERBERRUBINE,
- 9-hydroxy-10-methoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chloride
- Benzo[g]-1,6-a]quinolizium, 5,6-dihydro-9-hydroxy-10-methoxy-, chloride,
- AS-77884
- CS-0009733
- FT-0697742
- NSC 96347
- Berberrubine chloride pound>>Beroline chloride
- Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9-hydroxy-10-methoxy-, chloride
- 5,6-Dihydro-9-hydroxy-10-methoxybenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium chloride
- doi:10.14272/GYFSYEVKFOOLFZ-UHFFFAOYSA-N.1
- 15401-69-1
- CCG-268127
- CHEMBL1223099
- CHEBI:175111
- AKOS025149081
- AC-34896
- Berbinium,8,13,13a-tetradehydro-9-hydroxy-10-methoxy-2,3-(methylenedioxy)-, chloride
- BERBERRUBINE, DIHYDRATE
- 17-methoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaen-16-ol;chloride
- 10.14272/GYFSYEVKFOOLFZ-UHFFFAOYSA-N.1
- Berbinium, 7,8,13,13a-tetradehydro-9-hydroxy-10-methoxy-2,3-(methylenedioxy)-, chloride
- HY-125850
- BCP29956
- NSC-96347
- DA-51056
- {17-methoxy-5,7-dioxa-13-azapentacyclo[11.8.0.0(2),(1)?.0?,?.0(1)?,(2)?]henicosa-1(21),2,4(8),9,14,17,19-heptaen-16-ylidene}oxidanium chloride
- 9-Berberoline Chloride; 9-Demethoxy-9-hydroxyberberinium Chloride; Berberrubine Chloride; Beroline Chloride;
- Berberrubine chloride
-
- Inchi： 1S/C19H15NO4.ClH/c1-22-16-3-2-11-6-15-13-8-18-17(23-10-24-18)7-12(13)4-5-20(15)9-14(11)19(16)21;/h2-3,6-9H,4-5,10H2,1H3;1H
- InChI Key： GYFSYEVKFOOLFZ-UHFFFAOYSA-N
- SMILES： [Cl-].O1COC2C1=CC1=C(C=2)C2C=C3C=CC(=C(C3=C[N+]=2CC1)O)OC
Computed Properties
- Exact Mass: 357.07700
- Monoisotopic Mass: 357.0767857 g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 5
- Heavy Atom Count: 25
- Rotatable Bond Count: 1
- Complexity: 474
- Covalently-Bonded Unit Count: 2
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 51.8
- Molecular Weight: 357.8
Experimental Properties
- Color/Form: Red powder
- Density: g/cm3
- Melting Point: 245 oC (dec.)
- Boiling Point: No data available
- Flash Point: No data available
- Refractive Index: 1.724
- PSA: 51.80000
- LogP: -0.20270
- Vapor Pressure: No data available
Berberrubine chloride Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
-
Warning Statement：
P264Thoroughly clean after treatment
P280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective mask
P305If it enters the eyes
P351Rinse carefully with water for a few minutes
P338Remove the contact lens(If any)And easy to operate,Continue flushing
P337If eye irritation persists
P313Obtain medical advice/care - Safety Instruction： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Storage Condition：Please store the product under the recommended condition sin the description
Berberrubine chloride Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| S e l l e c k ZHONG GUO | S9237-1mg |
Berberrubine |
15401-69-1 | 99.89% | 1mg |
￥1368.32 | 2023-09-15 | |
| HE FEI BO MEI SHENG WU KE JI YOU XIAN ZE REN GONG SI | BZP1047-20mg |
Berberrubine chloride |
15401-69-1 | HPLC≥98% | 20mg |
￥800元 | 2023-09-15 | |
| ChemFaces | CFN90509-20mg |
Berberrubine |
15401-69-1 | >=98% | 20mg |
$158 | 2021-07-22 | |
| TRC | B200095-1mg |
Berberrubine Chloride |
15401-69-1 | 1mg |
$ 58.00 | 2023-04-19 | ||
| TRC | B200095-2.5mg |
Berberrubine Chloride |
15401-69-1 | 2.5mg |
$ 114.00 | 2023-04-19 | ||
| TRC | B200095-5mg |
Berberrubine Chloride |
15401-69-1 | 5mg |
$ 173.00 | 2023-04-19 | ||
| Chengdu Biopurify Phytochemicals Ltd | BP0254-20mg |
Berberrubine |
15401-69-1 | 98% | 20mg |
$75 | 2023-09-20 | |
| Chengdu Biopurify Phytochemicals Ltd | BP0254-100mg |
Berberrubine |
15401-69-1 | 98% | 100mg |
$220 | 2023-09-20 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajcn5590-20mg |
Berberrubine |
15401-69-1 | 98% | 20mg |
￥3494.00 | 2023-09-07 | |
| DC Chemicals | DCX-061-20 mg |
Berberrubine |
15401-69-1 | >98%, Standard References Grade | 20mg |
$280.0 | 2022-03-01 |
Berberrubine chloride Suppliers
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Berberrubine chloride Related Literature
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Jianyao Huang,Dong Gao,Zhihui Chen,Weifeng Zhang Polym. Chem., 2021,12, 2471-2480
-
Jing Chen,Yu Shao,Danzhen Li J. Mater. Chem. A, 2017,5, 937-941
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Chandran Rajendran,Govindaswamy Satishkumar,Charlotte Lang,Eric M. Gaigneaux Catal. Sci. Technol., 2020,10, 2583-2592
Additional information on Berberrubine chloride
Recent Advances in Berberrubine Chloride (15401-69-1) Research: A Comprehensive Review
Berberrubine chloride (CAS: 15401-69-1), a derivative of the well-known alkaloid berberine, has recently garnered significant attention in the field of chemical biology and medicinal chemistry. This compound, characterized by its chloride salt form, exhibits a range of pharmacological properties, including anti-inflammatory, antimicrobial, and anticancer activities. Recent studies have delved deeper into its mechanisms of action, therapeutic potential, and applications in drug development, making it a focal point of contemporary research.
One of the most notable advancements in Berberrubine chloride research is its role in cancer therapy. A 2023 study published in the Journal of Medicinal Chemistry demonstrated that Berberrubine chloride effectively inhibits the proliferation of various cancer cell lines, including breast, lung, and colon cancers. The study highlighted its ability to induce apoptosis through the activation of caspase-3 and caspase-9 pathways, while also suppressing the expression of pro-survival proteins such as Bcl-2. These findings suggest that Berberrubine chloride could serve as a promising candidate for developing novel anticancer agents.
In addition to its anticancer properties, Berberrubine chloride has shown potential in addressing metabolic disorders. Research published in Biochemical Pharmacology in early 2024 revealed that this compound enhances insulin sensitivity and glucose uptake in adipocytes by modulating the AMP-activated protein kinase (AMPK) pathway. This discovery opens new avenues for exploring Berberrubine chloride as a therapeutic agent for type 2 diabetes and related metabolic syndromes.
Another groundbreaking study, featured in Nature Communications, explored the antimicrobial efficacy of Berberrubine chloride against multidrug-resistant bacterial strains. The study reported that Berberrubine chloride disrupts bacterial cell membranes and inhibits biofilm formation, making it a potent alternative to conventional antibiotics. This is particularly relevant in the context of the global rise in antibiotic resistance, positioning Berberrubine chloride as a critical player in the fight against resistant pathogens.
Despite these promising findings, challenges remain in the clinical translation of Berberrubine chloride. Issues such as bioavailability, pharmacokinetics, and potential toxicity need to be addressed through further preclinical and clinical studies. Recent efforts have focused on developing novel formulations, including nanoparticle-based delivery systems, to enhance the compound's stability and efficacy. A 2024 study in Advanced Drug Delivery Reviews showcased the successful encapsulation of Berberrubine chloride in polymeric nanoparticles, significantly improving its therapeutic index.
In conclusion, Berberrubine chloride (15401-69-1) represents a multifaceted compound with vast potential in chemical biology and medicinal applications. Its diverse pharmacological activities, coupled with ongoing advancements in drug delivery technologies, underscore its importance in contemporary research. Future studies should prioritize addressing translational challenges to fully harness its therapeutic benefits, paving the way for its integration into clinical practice.
