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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxamides
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxamides

Comprehensive Overview of 5-Bromo-N-methylnicotinamide (CAS No. 153435-68-8): Properties, Applications, and Research Insights

5-Bromo-N-methylnicotinamide (CAS No. 153435-68-8) is a specialized organic compound that has garnered significant attention in pharmaceutical and biochemical research. This brominated derivative of nicotinamide is structurally characterized by a pyridine ring substituted with a bromine atom at the 5-position and an N-methylamide functional group. Its molecular formula, C₇H₇BrN₂O, and precise molecular weight of 215.05 g/mol make it a valuable intermediate in synthetic chemistry.

Researchers frequently explore 5-Bromo-N-methylnicotinamide for its role in modulating enzymatic activity, particularly in studies related to NAD+ metabolism and sirtuin pathways. These areas have gained traction due to growing interest in aging research and metabolic disorders. The compound's unique structure allows it to serve as a precursor for more complex molecules, enabling the development of novel therapeutic agents targeting inflammation and oxidative stress.

In recent years, the demand for high-purity 5-Bromo-N-methylnicotinamide has surged, driven by its applications in high-throughput screening and drug discovery platforms. Its compatibility with modern analytical techniques like LC-MS (Liquid Chromatography-Mass Spectrometry) and NMR spectroscopy makes it indispensable for quality control in research laboratories. The compound's stability under standard laboratory conditions (room temperature, inert atmosphere) further enhances its utility.

A key advantage of 153435-68-8 lies in its synthetic versatility. Chemists frequently employ it in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig couplings, to construct more elaborate heterocyclic systems. This aligns with current trends in green chemistry, where researchers seek efficient methods to reduce synthetic steps and minimize waste generation.

From a commercial perspective, 5-Bromo-N-methylnicotinamide suppliers must adhere to strict GMP standards to meet pharmaceutical industry requirements. Analytical certificates typically include data on HPLC purity (>98%), residual solvents, and heavy metal content. Storage recommendations generally suggest protection from light and moisture at 2-8°C for long-term stability.

Emerging studies suggest potential applications of 5-Bromo-N-methylnicotinamide derivatives in neuroprotective therapies, particularly in models of neurodegenerative diseases. This correlates with increasing public interest in brain health supplements and cognitive enhancers. However, thorough preclinical evaluation remains essential before any clinical translation.

The compound's safety profile has been documented in Material Safety Data Sheets (MSDS), emphasizing standard laboratory precautions including PPE (personal protective equipment) usage. Proper handling procedures recommend working in a fume hood and avoiding direct contact with skin or eyes, consistent with general chemical safety protocols.

For researchers sourcing CAS 153435-68-8, verification through spectroscopic fingerprinting (IR, ¹H/¹³C NMR) is crucial to ensure batch-to-batch consistency. Many laboratories now combine traditional characterization with computational chemistry approaches to predict reactivity patterns and optimize synthetic routes, reflecting the integration of AI-assisted drug design in modern research.

Environmental considerations for 5-Bromo-N-methylnicotinamide disposal follow standard protocols for brominated organic compounds, typically involving licensed waste management services. The scientific community continues to investigate biodegradation pathways for such intermediates to align with sustainable research practices.

Ongoing investigations explore the compound's potential in epigenetic modulation, particularly regarding histone deacetylase (HDAC) inhibition. This research avenue has gained momentum with increased understanding of epigenetic mechanisms in disease progression. Such studies often require custom synthesis of isotopically labeled versions (e.g., ¹³C or ¹⁵N) for advanced metabolic tracing experiments.

In summary, 5-Bromo-N-methylnicotinamide (CAS No. 153435-68-8) represents a multifaceted research chemical with expanding applications in medicinal chemistry and molecular biology. Its continued relevance stems from both its intrinsic chemical properties and its adaptability to cutting-edge research methodologies across interdisciplinary fields.

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