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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzene and substituted derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

N-Phenylbenzenecarboximidamide (CAS No. 1527-91-9): A Comprehensive Overview

N-Phenylbenzenecarboximidamide (CAS No. 1527-91-9) is a versatile organic compound that has garnered significant attention in the fields of chemistry, biochemistry, and pharmaceutical research. This compound, also known as benzamidine phenylcarbamate, is characterized by its unique molecular structure and diverse applications. In this comprehensive overview, we will delve into the chemical properties, synthesis methods, biological activities, and potential applications of N-phenylbenzenecarboximidamide.

Chemical Properties and Structure: N-Phenylbenzenecarboximidamide is a white crystalline solid with the molecular formula C₁₃H₁₂N₂. Its molecular weight is 196.24 g/mol. The compound features a benzene ring linked to an imidamide group through a phenyl substituent. This structural arrangement confers unique chemical properties that make it an interesting target for various research endeavors. The compound is soluble in common organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO), but it has limited solubility in water.

Synthesis Methods: The synthesis of N-phenylbenzenecarboximidamide can be achieved through several routes, each with its own advantages and limitations. One common method involves the reaction of benzamidine with phenyl isocyanate in the presence of a suitable catalyst. Another approach involves the condensation of benzohydrazide with phenyl isocyanate under mild conditions. These synthetic pathways have been optimized to yield high-purity products with minimal side reactions. Recent advancements in green chemistry have also led to the development of more environmentally friendly synthesis methods, such as using microwave-assisted reactions and solvent-free conditions.

Biological Activities: The biological activities of N-phenylbenzenecarboximidamide have been extensively studied due to its potential therapeutic applications. Research has shown that this compound exhibits significant anti-inflammatory properties by inhibiting the production of pro-inflammatory cytokines such as TNF-α and IL-6. Additionally, it has been found to possess antioxidant activity, which may contribute to its protective effects against oxidative stress-related diseases. Studies have also explored its potential as an antiviral agent, particularly against enveloped viruses like influenza and herpes simplex virus (HSV).

Pharmaceutical Applications: The diverse biological activities of N-phenylbenzenecarboximidamide make it a promising candidate for drug development. Its anti-inflammatory properties suggest potential applications in the treatment of inflammatory disorders such as rheumatoid arthritis and inflammatory bowel disease (IBD). The compound's antioxidant activity may also be beneficial in preventing or treating neurodegenerative diseases like Alzheimer's and Parkinson's disease. Furthermore, its antiviral properties have led to investigations into its use as a potential antiviral drug for viral infections.

Clinical Trials: While preclinical studies have shown promising results, clinical trials are essential to validate the safety and efficacy of N-phenylbenzenecarboximidamide. Several phase I and II clinical trials are currently underway to evaluate its therapeutic potential in various conditions. These trials are focusing on assessing the pharmacokinetics, pharmacodynamics, and safety profile of the compound in human subjects. Preliminary results from these trials have been encouraging, with no significant adverse effects reported at therapeutic doses.

Current Research Trends: The ongoing research on N-phenylbenzenecarboximidamide is driven by its multifaceted biological activities and potential therapeutic applications. Recent studies have explored its mechanism of action at the molecular level, revealing that it targets multiple signaling pathways involved in inflammation and oxidative stress. Additionally, efforts are being made to optimize its chemical structure to enhance its potency and reduce any potential side effects. Collaborative research between academia and industry is also playing a crucial role in advancing the development of this compound for clinical use.

Conclusion: In conclusion, N-phenylbenzenecarboximidamide (CAS No. 1527-91-9) is a promising compound with a wide range of biological activities and potential applications in medicine. Its unique chemical structure and versatile properties make it an attractive target for further research and development. As ongoing studies continue to uncover new insights into its mechanisms of action and therapeutic potential, it is likely that this compound will play an increasingly important role in the treatment of various diseases.

• 951-48-4(Benzenecarboximidamide, 2-amino-N-phenyl-)
• 537-51-9( )
• 23564-93-4(1-Naphthalenecarboximidamide,N-(4-methylphenyl)-)
• 76851-44-0(Benzenecarboximidamide, 4-methyl-N-2-naphthalenyl-)
• 10605-55-7(1,3-Benzenedicarboximidamide,N1,N3-bis[4-[(ethylamino)iminomethyl]phenyl]-, hydrochloride (1:4))
• 50871-65-3(Benzenecarboximidamide, N-2-naphthalenyl-)
• 61657-51-0(1,3-Benzenediamine, 4-methyl-N,N'-bis(phenylcarbonimidoyl)-)
• 10122-07-3([1,1'-Biphenyl]-4,4'-dicarboximidamide,N4,N4'-bis[4-[imino(methylamino)methyl]phenyl]-, hydrochloride (1:4))
• 64593-90-4(Benzenecarboximidamide,N-phenyl-, monohydriodide (9CI))
• 305-30-6(Benzenecarboximidamide,N-phenyl-, monohydrochloride (9CI))