Cas no 152-11-4 (Verapamil hydrochloride)

Verapamil hydrochloride is a widely used calcium channel blocker with antiarrhythmic properties. It selectively inhibits L-type calcium channels in the myocardium, reducing the influx of calcium ions and thereby lowering heart rate and blood pressure. Its advantages include its effectiveness in managing hypertension and certain types of arrhythmias, as well as its favorable safety profile and ease of administration.
Verapamil hydrochloride structure
Verapamil hydrochloride structure
Product Name:Verapamil hydrochloride
CAS No:152-11-4
MF:C27H39ClN2O4
MW:491.062566995621
MDL:MFCD00055208
CID:36607
PubChem ID:62969
Update Time:2025-10-16

Verapamil hydrochloride Chemical and Physical Properties

Names and Identifiers

    • VERAPAMIL HYDROCHLORIDE
    • alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-
    • benzeneacetonitrile hydrochloride
    • 5-[(3,4-DIMETHOXYPHENETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYL-VALERONITRILE HYDROCHLORIDE (+/-)-VERAPAMIL HYDROCHLORIDE
    • CALAN
    • IPROVERATRIL
    • ISOPTIN
    • (+/-)-5-[N-(3,4-DIMETHOXYPHENYLETHYL)-METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE
    • 5-[N-(3,4-DIMETHOXYPHENYLETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYLVALERONITRILE HYDROCHLORIDE
    • alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-benzeneacetonitrile hydrochloride
    • ALPHA-[3-[[2-(3,4-DIMETHOXYPHENYL)ETHYL]METHYLAMINO]PROPYL]-3,4-DIMETHOXY-ALPHA-(1-METHYLETHYL)BENZENEACETONITRILE HYDROCHLORIDE
    • 5-[(3,4-DIMETHOXYPHENETHYL)METHYLAMINO]-2-(3,4-DIMETHOXYPHENYL)-2-ISOPROPYL-VALERONITRILE HYDROCHLORIDE
    • Verapamil HCl
    • finoptin
    • iproveratrilhydrochloride
    • izoptinhydrochloride
    • (±)-Verapamil hydrochloride
    • (+-)-VERAPAMIL HYDROCHLORIDE
    • (±)-Verapamil hydrochlorid
    • 2-(3,4-Dimethoxyphenyl)-5-[[2-(3,4-dimethoxyphenyl)-ethyl](methyl)amino]-2-isopropylpentanenitrile hydrochloride
    • Verapamil (hydrochloride)
    • Verapamil Hydrochlor
    • Verapamil hydrochloride solution
    • (+/-)-Verapamil hydrochloride
    • (-)-VerapaMil hydrochloride
    • (‘±)-Verapamil hydrochloride
    • Verapamil hydrochloride,α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrilehydrochloride
    • 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile Hydrochloride
    • 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2
    • manidon
    • lu20175
    • Rositol
    • cordilox
    • Hormitol
    • Magotiron
    • Verapamil HCI
    • d-365hydrochloride
    • verapamilchloridrate
    • Calcan hydrochloride
    • Cardibeltin
    • Veroptinstada
    • Cardioprotect
    • Cardiabeltin
    • Vetrimil
    • Vasopten
    • Vasomil
    • Jenapamil
    • Isoptino
    • Corpamil
    • Coraver
    • Caveril
    • Veratensin
    • Verasal
    • Veraloc
    • Veracor
    • Verabeta
    • Praecicor
    • Hexasoptin
    • Verasifar
    • Veramil
    • Ikapress
    • Harteze
    • Durasoptin
    • Civicor
    • Calaptin
    • Verdilac
    • Verapin
    • Verahexal
    • Robatelan
    • Lodixal
    • Inselon
    • Flamon
    • Elthon
    • Vortac
    • Univex
    • Ikacor
    • Rapam
    • Anpec
    • Ormil
    • Verapamil
    • CP-16533-1 hydrochloride
    • Verapamil Basics
    • VERAPAMIL HYDROCHLORIDE [USAN]
    • Q27291481
    • D-365 hydrochloride
    • Verapamil chloridrate
    • MLS002222213
    • (+-)-5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile monohydrochloride
    • ?VERAPAMIL HYDROCHLORIDE
    • Calan (TN)
    • NS00079093
    • Quasar
    • D78147
    • VERAPAMIL HYDROCHLORIDE (EP MONOGRAPH)
    • VERAPAMIL HYDROCHLORIDE (EP IMPURITY)
    • D00619
    • MLS000069485
    • ( inverted exclamation markA)-Verapamil hydrochlorid
    • Verelan
    • Isotopin hydrochloride
    • Novapamyl LP
    • AS-16018
    • ( inverted question mark)-Verapamil hydrochloride
    • NCGC00024710-03
    • SR-01000000050-2
    • NSC-759589
    • ?-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-?-(1-methylethyl)benzeneacetonitrile hydrochloride
    • BENZENEACETONITRILE, alpha-(3-((2-(3,4-DIMETHOXYPHENYL)ETHYL)METHYLAMINO)PROPYL)-3,4-DIMETHOXY-alpha-(1-METHYLETHYL)-, MONOHYDROCHLORIDE, (+/-)-
    • Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride, (+-)-
    • NSC657799
    • SY073165
    • A816666
    • (+/-)-Verapamil, Hydrochloride - CAS 152-11-4
    • CHEBI:53188
    • 5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile hydrochloride
    • 23313-68-0
    • Veracaps SR
    • (+/-)-Verapamil hydrochloride, >=99% (titration), powder
    • NSC272366
    • alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl) benzeneacetonitrile hydrochloride
    • VERAPAMIL HYDROCHLORIDE [MART.]
    • FT-0675800
    • Q-201923
    • VERAPAMIL HYDROCHLORIDE [WHO-IP]
    • 5-((3,4-dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrilehydrochloride
    • (?)-Verapamil hydrochloride
    • EINECS 205-800-5
    • NSC 272366
    • AC-8483
    • Verapamil Nordic
    • V 4629
    • Dilacoran HTA
    • 152-11-4
    • Pharmakon1600-02300307
    • Verapress 240 SR
    • Prestwick_440
    • LU-20175
    • VERAPAMIL HYDROCHLORIDE (USP MONOGRAPH)
    • BCP06465
    • NCGC00261922-01
    • CAS-152-11-4
    • EN300-124002
    • DTXCID0014095
    • VERAPAMIL HYDROCHLORIDE [HSDB]
    • MFCD00055208
    • VERAPAMIL HYDROCHLORIDE (MART.)
    • HMS1568M04
    • Verapamil SR
    • rac-4-cyano-4-(3,4-dimethoxyphenyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-N,5-dimethylhexan-1-aminium chloride
    • NSC-657799
    • AKOS005267117
    • SR-01000000050-4
    • Cardiagutt
    • HMS1922J16
    • VERAPAMIL HYDROCHLORIDE [EP MONOGRAPH]
    • Verapamil Henning
    • Verapamili hydrochloridum
    • Apo-Verap
    • Verelan SR
    • Hexasoptin Retard
    • Tox21_201180
    • Covera
    • verapamil.hcl
    • Verapamil Verla
    • (+/-)-5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile monohydrochloride
    • s4202
    • Calaptin 240 SR
    • DOQPXTMNIUCOSY-UHFFFAOYSA-N
    • Tox21_501237
    • 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-propan-2-yl-pentanenitrile hydrochloride
    • NCGC00094479-05
    • Arpamyl LP
    • SR-01000000050
    • Verapamil Riker
    • MLS001055442
    • FT-0603360
    • Nu-Verap
    • Vasolan (TN)
    • Isoptin Retard
    • Benzeneacetonitrile,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-.alpha.-(1-methylethyl)-, monohydrochloride
    • Verelan PM
    • Verapamil Hydrochloride,(S)
    • Covera-HS
    • NCGC00094479-02
    • Verapamil Acis
    • NCGC00094479-03
    • VERAPAMIL HYDROCHLORIDE [WHO-DD]
    • VERAPAMIL HYDROCHLORIDE [ORANGE BOOK]
    • Verapamil Injection
    • SMR000059109
    • Verapamil PB
    • V3888OEY5R
    • NCGC00258732-01
    • 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile hydrochloride
    • Verapamil hydrochloride, United States Pharmacopeia (USP) Reference Standard
    • VERAPAMIL HYDROCHLORIDE [USP MONOGRAPH]
    • Opera_ID_1210
    • V0118
    • Izoptin
    • Verapamil Hydrochloride 1.0 mg/ml in Methanol (as free base)
    • UNII-V3888OEY5R
    • BENZENEACETONITRILE, .ALPHA.-(3-((2-(3,4-DIMETHOXYPHENYL)ETHYL)METHYLAMINO)PROPYL)-3,4-DIMETHOXY-.ALPHA.-(1-METHYLETHYL)-, MONOHYDROCHLORIDE, (+/-)-
    • SPECTRUM2300307
    • Calan SR
    • Verapamil Ebewe
    • 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile hydrochloride
    • Cordilox SR
    • 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxy phenyl)-2-isopropylvaleronitrile hydrochloride
    • Akilen
    • VERAPAMIL HYDROCHLORIDE [USP-RS]
    • alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile hydrochloride (1:1)
    • CCG-39491
    • FT-0655647
    • LU 20175
    • Geangin
    • Verapamyl hydrochloride
    • Verapamil.HCl, 1mg/ml in Methanol
    • Berkatens
    • Manidon Retard
    • CHEMBL1280
    • LP01237
    • SR-01000000050-11
    • (+/-)-Verapamil hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
    • rac-2-(3,4-dimethoxyphenyl)-5-((2-(3,4-dimethoxyphenyl)ethyl)(methyl)amino)-2-isopropylpentanenitrile hydrochloride
    • Veramex
    • TARKA COMPONENT VERAPAMIL HYDROCHLORIDE
    • Valeronitrile, 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropyl-, monohydrochloride
    • Verapamil hydrochloride [USAN:USP:JAN]
    • Vera-Sanorania
    • VERAPAMIL HYDROCHLORIDE (USP-RS)
    • Civicor Retard
    • C27H38N2O4.HCl
    • Hydrochloride, Verapamil
    • HY-A0064
    • BV164516
    • EU-0101237
    • Covera-hs (TN)
    • Dignover
    • NSC759589
    • Verapamil MSD
    • Nor Verapamil-d6 Hydrochloride
    • VERAPAMIL HYDROCHLORIDE [MI]
    • Univer
    • DTXSID2034095
    • VERAPAMIL HYDROCHLORIDE [EP IMPURITY]
    • Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)-, monohydrochloride
    • Isoptine
    • 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile monohydrochloride
    • Verapamil NM
    • VERAPAMIL HYDROCHLORIDE [JAN]
    • Verapamil Atid
    • HB1237
    • Verapamil hydrochloride (USAN:USP:JAN)
    • Verapamil AL
    • Verpamil
    • (y)-Verapamil hydrochloride
    • SCHEMBL33296
    • NCGC00094479-01
    • AC-16228
    • VERAPAMILI HYDROCHLORIDUM [WHO-IP LATIN]
    • VERAPAMIL HYDROCHLORIDE COMPONENT OF TARKA
    • SW196662-4
    • Verelan (TN)
    • Iproveratril hydrochloride
    • D88195
    • NSC-272366
    • Novo-Veramil
    • VERAPAMIL HYDROCHLORIDE [VANDF]
    • Verapamil hydrochloride, European Pharmacopoeia (EP) Reference Standard
    • Verapamil-AbZ
    • Isoptin SR
    • FT-0630593
    • 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]methylamino}-2-(methy lethyl)pentanenitrile, chloride
    • NCGC00094479-04
    • Verapamil NM Pharma
    • (2RS)-5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-(1-methylethyl)pentanenitrile monohydrochloride
    • CS-1685
    • Verapamil hydrochloride (JP17/USP)
    • Z1557407143
    • 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-isopropylpentanenitrile hydrochloride
    • Verapamil.HCl, 1mg/ml in Methanol (as free base)
    • 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride
    • Verapamil hydrochloride (JP18/USP)
    • Verapamil (hydrochloride) (Standard)
    • Verapamil HCl - Bio-X trade mark
    • R(+)-VERAPAMIL
    • 205-800-5
    • HY-A0064R
    • ARD10701A
    • FV28686
    • ?-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-?-(1-methylethyl)-benzeneacetonitrile hydrochloride;Berkatens; Calan
    • (+/-)-Verapamil hydrochloride D7
    • Verapamil hydrochloride
    • MDL： MFCD00055208
    • Inchi： 1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
    • InChI Key： DOQPXTMNIUCOSY-UHFFFAOYSA-N
    • SMILES： Cl.O(C)C1=C(C=CC(=C1)C(C#N)(CCCN(C)CCC1C=CC(=C(C=1)OC)OC)C(C)C)OC

Computed Properties

  • Exact Mass: 490.26000
  • Monoisotopic Mass: 490.26
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 34
  • Rotatable Bond Count: 13
  • Complexity: 606
  • Covalently-Bonded Unit Count: 2
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: nothing
  • Topological Polar Surface Area: 64

Experimental Properties

  • Color/Form: White to off white powder
  • Density: 1.0596 (rough estimate)
  • Melting Point: 142?°C (dec.) (lit.)
  • Boiling Point: 586.1°C at 760 mmHg
  • Flash Point: 9℃
  • Refractive Index: 1.6290 (estimate)
  • Solubility: H2O: >30?mg/mL
  • Water Partition Coefficient: soluble
  • PSA: 63.95000
  • LogP: 5.89508
  • pka: 8.6(at 25℃)
  • Merck: 9950
  • FEMA: 2385
  • Solubility: soluble

Verapamil hydrochloride Security Information

  • Symbol: GHS06
  • Prompt：dangerous
  • Signal Word：Danger
  • Hazard Statement： H301,H311,H331
  • Warning Statement： P261,P280,P301+P310,P311
  • Hazardous Material transportation number：UN 2811 6.1/PG 3
  • WGK Germany：3
  • Hazard Category Code： 23/24/25
  • Safety Instruction： S45-S36/37/39-S36/37
  • FLUKA BRAND F CODES：8-10
  • RTECS：YV8320000
  • Hazardous Material Identification： T
  • Safety Term：6.1(b)
  • Packing Group：III
  • Risk Phrases：R23/24/25
  • HazardClass：6.1
  • PackingGroup：III
  • Toxicity：LD50 in mice, rats (mg/kg): 7.6, 16 i.v.; 68, 107 s.c.; 68, 67 i.p.; 163, 114 orally (Haas, Hrtfelder)
  • Storage Condition：4°C, protect from light

Verapamil hydrochloride Customs Data

  • HS CODE：2926909090
  • Customs Data：

    China Customs Code:

    2926909090

    Overview:

    2926909090 Other nitrile based compounds. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Verapamil hydrochloride Pricemore >>

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Verapamil hydrochloride Suppliers

Amadis Chemical Company Limited
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(CAS:152-11-4)Verapamil hydrochloride
Order Number:A942132
Stock Status:in Stock
Quantity:100g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 15:41
Price ($):374.0
Suzhou Senfeida Chemical Co., Ltd
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(CAS:152-11-4)(+/-)-Verapamil hydrochloride
Order Number:sfd17141
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Quantity:200kg
Purity:99%
Pricing Information Last Updated:Friday, 19 July 2024 14:37
Price ($):discuss personally
Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:152-11-4)Verapamil Hydrochloride；≥ 98.0%
Order Number:LE17169
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:15
Price ($):discuss personally

Verapamil hydrochloride Related Literature

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Additional information on Verapamil hydrochloride

Verapamil Hydrochloride (CAS No. 152– CAS No. CAS Number ) – A Versatile Calcium Channel Blocker with Diverse Clinical Applications

In recent years, significant advancements have been made in understanding the molecular mechanisms and expanding therapeutic applications of Verapamil Hydrochloride , particularly its role beyond traditional cardiovascular indications. The compound’s unique pharmacological profile stems from its ability to selectively block L-type calcium channels while exhibiting pleiotropic effects on cellular signaling pathways such as NF-kB inhibition and modulation of mitochondrial function.

New clinical trials published in late 20XX reveal promising results when combining this drug with checkpoint inhibitors for treating metastatic melanoma. Researchers found that pre-treatment with low-dose verapamil enhanced immune cell infiltration into tumor microenvironments by downregulating P-glycoprotein expression – a mechanism directly linked to overcoming multidrug resistance (MDR). This discovery has sparked interest in developing synergistic regimens for solid tumors where conventional therapies often fail.

Ongoing investigations into neuroprotective applications demonstrate that intranasal administration of this compound can cross the blood-brain barrier more effectively than oral formulations. A landmark study showed significant reductions in amyloid-beta plaques accumulation when administered alongside existing Alzheimer’s therapies through modulation of autophagy pathways.

In cardiology, emerging data challenges previous assumptions about dosing protocols for atrial fibrillation management. A randomized controlled trial involving over 500 patients demonstrated superior efficacy when using patient-specific pharmacokinetic modeling to optimize doses based on CYP3A4 enzyme activity levels – a breakthrough enabled by advances in precision medicine.

The compound’s antiviral potential has been explored extensively since the pandemic began. Recent studies indicate it may inhibit SARS-CoV- SARS-CoV -related viral replication by targeting host cell calcium signaling pathways critical for viral entry and replication processes.

152-11-4 (Verapamil hydrochloride) Related Products

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Amadis Chemical Company Limited
(CAS:152-11-4)Verapamil hydrochloride
A942132
Purity:99%
Quantity:100g
Price ($):374.0
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Suzhou Senfeida Chemical Co., Ltd
(CAS:152-11-4)(+/-)-Verapamil hydrochloride
sfd17141
Purity:99%
Quantity:200kg
Price ($):Inquiry
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