• 1. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 2. Distinct impact of glycation towards the aggregation and toxicity of murine and human amyloid-β?
  Eunju Nam,Jiyeon Han,Sunhee Choi,Mi Hee Lim Chem. Commun., 2021,57, 7637-7640
• 3. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 4. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
• 5. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477

• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Cinnamic acids and derivatives Cinnamic acids

α-Cyano-4-methoxycinnamic acid (CAS No. 1519-55-7): A Versatile Compound in Modern Scientific Research

α-Cyano-4-methoxycinnamic acid, often abbreviated as α-CCA or 4-methoxycinnamic acid derivative, is a highly specialized organic compound with significant applications in analytical chemistry and material science. Its CAS registry number, 1519-55-7, is a critical identifier for researchers sourcing this compound. The molecule features a cyano group (-CN) and a methoxy substituent (-OCH₃) on its aromatic ring, which contribute to its unique physicochemical properties, including UV absorption and matrix-assisted laser desorption/ionization (MALDI) compatibility.

In recent years, α-Cyano-4-methoxycinnamic acid has gained attention due to its role as a MALDI matrix for mass spectrometry. Scientists frequently search for "best MALDI matrix for peptides" or "1519-55-7 solubility in acetonitrile," highlighting its practical relevance. The compound’s ability to facilitate ionization of biomolecules like proteins and peptides makes it indispensable in proteomics research. Its optimized crystal structure promotes efficient energy transfer during laser irradiation, a topic often explored in "MALDI-TOF method optimization" discussions.

Beyond mass spectrometry, α-CCA is investigated for its photophysical properties. Researchers studying "organic UV absorbers" or "nonlinear optical materials" have reported its potential in photostabilizers and optoelectronic devices. The compound’s conjugated π-system and electron-withdrawing cyano group enable applications in "fluorescence quenching studies" and "solar cell materials," aligning with renewable energy trends.

Synthetic protocols for 1519-55-7 often involve Knoevenagel condensation, a reaction frequently queried as "how to synthesize α-cyano cinnamic acid derivatives." The compound’s purity (>98%) is crucial for reproducibility, a concern reflected in searches like "HPLC purification of MALDI matrices." Storage recommendations (e.g., "1519-55-7 stability at -20°C") are also widely discussed, emphasizing its sensitivity to light and humidity.

In material science, 4-methoxycinnamic acid derivatives are explored for cocrystal engineering. Queries such as "co-crystallization with API using α-CCA" demonstrate its utility in pharmaceutical solid-state chemistry. Its hydrogen-bonding capacity and polymorphic behavior are subjects of ongoing research, particularly in "crystal structure prediction" algorithms.

From an industrial perspective, α-Cyano-4-methoxycinnamic acid is manufactured under strict GMP guidelines for research use. FAQs like "1519-55-7 supplier with COA" or "bulk pricing for α-CCA" reflect commercial interest. Regulatory compliance (e.g., "REACH certification for 1519-55-7") ensures its safe handling in laboratories worldwide.

Emerging studies link α-CCA to antimicrobial coatings, responding to searches like "cinnamic acid derivatives as biocides." Its methoxy group’s role in enhancing bioactivity is a hotspot in "structure-activity relationship (SAR) studies." Such applications align with global demands for novel antimicrobial solutions.

In summary, CAS 1519-55-7 represents a nexus of interdisciplinary research. Whether as a "MALDI-MS matrix" or a "photoactive material precursor," its versatility continues to inspire innovations. The compound’s optimization for "high-throughput screening" and "green chemistry synthesis" remains a vibrant area of exploration, ensuring its enduring relevance in science.

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