• 1. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 3. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
  Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
• 4. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 5. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

2-Amino-3-[4-(methoxycarbonyl)phenyl]propanoic Acid (CAS No. 151872-17-2): A Comprehensive Overview

2-Amino-3-[4-(methoxycarbonyl)phenyl]propanoic acid (CAS No. 151872-17-2) is a specialized organic compound that has garnered significant attention in the fields of medicinal chemistry, peptide synthesis, and biochemical research. This compound, often referred to as a non-proteinogenic amino acid derivative, is structurally characterized by a phenyl ring substituted with a methoxycarbonyl group and an amino acid backbone. Its unique properties make it a valuable building block for designing novel peptide-based therapeutics and bioconjugates.

The growing interest in 2-amino-3-[4-(methoxycarbonyl)phenyl]propanoic acid is driven by its potential applications in drug discovery and biopharmaceutical development. Researchers are particularly intrigued by its role in modulating peptide stability and bioavailability, which are critical factors in the development of targeted therapies. With the rise of personalized medicine and precision drug delivery systems, this compound has emerged as a key player in the synthesis of customized peptide sequences.

One of the most frequently searched questions related to this compound is: "What are the synthetic routes for 2-amino-3-[4-(methoxycarbonyl)phenyl]propanoic acid?" The synthesis typically involves multi-step organic reactions, including esterification, protection-deprotection strategies, and chiral resolution techniques. Advanced methods such as asymmetric catalysis and enzymatic resolution are also employed to achieve high enantiomeric purity, which is essential for its application in chiral drug development.

Another hot topic in the scientific community is the structure-activity relationship (SAR) of 2-amino-3-[4-(methoxycarbonyl)phenyl]propanoic acid. Studies have shown that the methoxycarbonyl group enhances the compound's lipophilicity, thereby improving its membrane permeability—a desirable trait for CNS-targeting drugs. This has led to increased exploration of its derivatives in the context of neurodegenerative disease research, such as Alzheimer's and Parkinson's.

From a commercial perspective, the demand for high-purity 2-amino-3-[4-(methoxycarbonyl)phenyl]propanoic acid has surged due to its utility in peptide-based vaccines and diagnostic reagents. The compound's compatibility with solid-phase peptide synthesis (SPPS) protocols makes it a preferred choice for pharmaceutical manufacturers. Additionally, its role in biomarker discovery and proteomics research has further expanded its market potential.

Environmental and regulatory considerations are also part of the discourse surrounding this compound. While it is not classified as a hazardous substance, proper handling and storage are recommended to maintain its stability. Researchers often inquire about "the shelf life of 2-amino-3-[4-(methoxycarbonyl)phenyl]propanoic acid", which is typically extended when stored under inert conditions at low temperatures.

In summary, 2-amino-3-[4-(methoxycarbonyl)phenyl]propanoic acid (CAS No. 151872-17-2) represents a versatile and scientifically significant compound with broad applications in modern chemistry and biotechnology. Its relevance to cutting-edge research areas like peptide engineering, drug delivery optimization, and therapeutic agent design ensures its continued prominence in both academic and industrial settings.

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