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  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 2. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?
  Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615
• 3. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 4. An apparatus for determining small amounts of alchohol in sour milk and urine
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• Solvents and Organic Chemicals Organic Compounds Organic 1,3-dipolar compounds Allyl-type 1,3-dipolar organic compounds C-nitro compounds
• Solvents and Organic Chemicals Organic Compounds Organic 1,3-dipolar compounds Allyl-type 1,3-dipolar organic compounds Organic nitro compounds C-nitro compounds

Recent Advances in the Study of 3-Hydroxy-6-methyl-2-nitropyridine (CAS: 15128-90-2)

The compound 3-Hydroxy-6-methyl-2-nitropyridine (CAS: 15128-90-2) has garnered significant attention in recent years due to its potential applications in the fields of chemical biology and pharmaceutical research. This heterocyclic compound, characterized by its nitro and hydroxy functional groups, has been explored for its unique chemical properties and biological activities. Recent studies have focused on its synthesis, structural modifications, and potential therapeutic applications, making it a subject of considerable scientific interest.

One of the key areas of research involving 3-Hydroxy-6-methyl-2-nitropyridine is its role as a building block in the synthesis of more complex molecules. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its utility in the development of novel kinase inhibitors. The study highlighted the compound's ability to act as a scaffold for the introduction of various pharmacophores, leading to the creation of molecules with enhanced binding affinity and selectivity for specific kinase targets. This research opens new avenues for the design of targeted therapies in oncology and other disease areas.

In addition to its synthetic applications, 3-Hydroxy-6-methyl-2-nitropyridine has been investigated for its intrinsic biological activities. A recent preprint on bioRxiv reported its moderate antimicrobial activity against several Gram-positive bacterial strains, including Staphylococcus aureus. The study suggested that the nitro group plays a crucial role in this activity, possibly through the generation of reactive oxygen species. While further optimization is needed to improve potency and reduce potential toxicity, these findings position the compound as a promising lead for the development of new antibacterial agents.

The metabolic fate and pharmacokinetic properties of 3-Hydroxy-6-methyl-2-nitropyridine have also been subjects of recent investigation. A 2024 paper in Drug Metabolism and Disposition employed advanced LC-MS techniques to characterize the compound's metabolic pathways in human liver microsomes. The study identified several phase I and phase II metabolites, providing valuable insights into its potential drug-drug interactions and guiding future structural modifications to improve metabolic stability. These findings are particularly relevant for researchers considering this scaffold for drug development programs.

From a chemical perspective, innovative synthetic approaches to 3-Hydroxy-6-methyl-2-nitropyridine have been developed to address previous limitations in yield and purity. A recent publication in Organic Process Research & Development described a continuous flow chemistry method that significantly improves the scalability of the synthesis while reducing environmental impact through decreased solvent usage. This technological advancement could facilitate broader access to the compound for research purposes and potential commercial applications.

Looking forward, the diverse research applications of 3-Hydroxy-6-methyl-2-nitropyridine suggest it will remain an important compound in chemical biology and medicinal chemistry. Current studies are exploring its potential in areas such as fluorescent probes for biological imaging and as a ligand in catalytic systems. As research continues to uncover new properties and applications for this versatile molecule, it is likely to play an increasingly significant role in the development of novel therapeutic agents and research tools in the coming years.

• 15128-82-2(2-nitropyridin-3-ol)
• 15128-84-4(2-methyl-6-nitro-pyridin-3-ol)
• 1022250-67-4(4-Bromo-6-methyl-2-nitropyridin-3-ol)
• 23904-02-1(3-Methoxy-2-methyl-6-nitro-pyridine)
• 24015-98-3(3-Methoxy-6-methyl-2-nitropyridine)
• 15128-08-2(2-Nitro-3-hydroxypyridine)
• 18368-61-1(2-methyl-6-nitro-pyridine)
• 15128-91-3(2,6-Dinitro-3-pyridinol)
• 15128-88-8(5-methyl-2-nitropyridin-3-ol)
• 341010-92-2(5-hydroxy-6-nitropyridine-2-carboxylic Acid)