• 1. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 2. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 3. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 4. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 5. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477

6-Aminoindolin-2-one (CAS No. 150544-04-0): A Comprehensive Overview of Properties, Applications, and Market Trends

6-Aminoindolin-2-one (CAS No. 150544-04-0) is a significant heterocyclic compound that has garnered attention in pharmaceutical research and organic synthesis. This aminoindolinone derivative serves as a versatile building block for various bioactive molecules, particularly in drug discovery programs targeting neurological and oncological indications.

The molecular structure of 6-Amino-2-indolinone features both amino and carbonyl functional groups on its indole-like scaffold, making it an attractive intermediate for medicinal chemistry. Recent studies highlight its potential as a precursor for kinase inhibitors and GPCR modulators, aligning with current trends in precision medicine development.

From a synthetic chemistry perspective, 6-Aminoindolin-2-one hydrochloride demonstrates excellent solubility in polar solvents while maintaining stability under standard laboratory conditions. Researchers particularly value its compatibility with modern cross-coupling reactions and catalytic hydrogenation processes, which are frequently searched topics in chemical synthesis forums.

In pharmaceutical applications, this compound has shown promise in the development of neuroprotective agents and anticancer compounds, addressing two of the most searched health topics in scientific databases. Its structural similarity to endogenous neurotransmitters makes it particularly interesting for CNS drug discovery programs.

The global market for indolinone derivatives like 6-Aminoindolin-2-one has shown steady growth, with increasing demand from contract research organizations and academic laboratories. Market analysis reveals particular interest from regions with strong pharmaceutical R&D infrastructure, correlating with Google Trends data showing rising searches for "specialty chemical suppliers" in these areas.

Quality specifications for CAS 150544-04-0 typically include HPLC purity ≥98% and rigorous control of residual solvents. Analytical methods such as LC-MS characterization and NMR spectroscopy are commonly employed for verification, topics that frequently appear in chemistry-related search queries.

Recent patent literature demonstrates innovative applications of 6-Aminoindolin-2-one derivatives in photodynamic therapy and diagnostic imaging agents. These developments correspond with increasing public interest in non-invasive treatment methods, as evidenced by search engine data on "next-generation therapeutics."

Environmental and safety profiles of 6-Aminoindolin-2-one have been thoroughly documented, showing favorable biodegradability characteristics. This aspect aligns with growing industry focus on green chemistry principles, a trending topic in both academic and industrial chemistry circles.

Future research directions for this compound include exploration of its metal complexation properties and potential in catalysis applications. These areas match emerging search trends in advanced materials science and sustainable chemical processes.

For researchers sourcing this material, technical considerations include optimal storage conditions (typically 2-8°C under inert atmosphere) and compatibility with common peptide coupling reagents. Such practical information is frequently sought after in chemical procurement searches.

The synthesis scale-up of 6-Aminoindolin-2-one presents interesting engineering challenges that have been addressed in recent chemical engineering publications. Process optimization strategies for this compound often appear in searches related to "continuous flow chemistry" and "process intensification."

Academic interest in this compound continues to grow, with citation rates for publications involving 150544-04-0 showing an upward trajectory. This correlates with increasing searches for "heterocyclic compound research" across scientific databases.

In analytical applications, derivatives of 6-Aminoindolin-2-one have shown utility as fluorescent probes and chromogenic reagents. These applications address current research needs in bioimaging and sensor development, topics showing increased search volume in recent years.

The compound's structural features make it amenable to various structure-activity relationship studies, particularly relevant to researchers investigating "molecular modeling" and "drug design principles," which are consistently high-volume search terms in medicinal chemistry.

As the pharmaceutical industry continues to explore targeted therapies, the role of 6-Aminoindolin-2-one as a privileged scaffold is likely to expand. Market projections suggest growing demand for this compound, especially in regions with developing biotechnology sectors.

• 3335-98-6(1-Phenyl-1,3-dihydro-2H-indol-2-one)
• 3484-35-3(5-Methylindolin-2-one)
• 3680-28-2(7-Methylindolin-2-one)
• 1504-06-9(3-Methyloxindole)
• 64483-69-8(5-Acetyloxindole)
• 59-48-3(Oxindole)
• 20870-91-1(5-amino-1-methyl-2,3-dihydro-1H-indol-2-one)
• 13220-46-7(4-methyl-2,3-dihydro-1H-indol-2-one)
• 61-70-1(1-Methyl-2-oxindole (1-Methyl-2-indolone))
• 729598-50-9(5,7-Dimethylindolin-2-one)