• 1. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 3. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
• 4. Excited-state proton-coupled electron transfer within ion pairs?
  Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473
• 5. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409

5-Bromo-4-(cyclohexylmethyl)thiazole-2-carboxylic acid (CAS No. 1501854-55-2): A Comprehensive Overview

5-Bromo-4-(cyclohexylmethyl)thiazole-2-carboxylic acid (CAS No. 1501854-55-2) is a specialized thiazole derivative that has gained significant attention in pharmaceutical and agrochemical research. This compound, with its unique brominated thiazole structure and cyclohexylmethyl substitution, offers versatile applications in drug discovery and material science. The molecular formula C₁₁H₁₄BrNO₂S indicates its moderate molecular weight (296.2 g/mol), making it suitable for various synthetic modifications.

The growing interest in heterocyclic compounds like 5-Bromo-4-(cyclohexylmethyl)thiazole-2-carboxylic acid stems from their remarkable biological activities. Researchers particularly value its potential as a pharmacophore in developing kinase inhibitors and antimicrobial agents. The presence of both bromo and carboxylic acid functional groups allows for diverse chemical transformations, enabling the creation of novel derivatives with enhanced properties.

In the context of current research trends, this compound aligns with several hot topics in medicinal chemistry. The search for new small molecule therapeutics and bioactive scaffolds has increased demand for such thiazole-based building blocks. Its structural features make it particularly relevant for studies involving fragment-based drug design and targeted protein degradation strategies, which are among the most searched topics in AI-powered drug discovery platforms.

The physicochemical properties of 5-Bromo-4-(cyclohexylmethyl)thiazole-2-carboxylic acid contribute to its research utility. With calculated logP values suggesting moderate lipophilicity, this compound demonstrates good membrane permeability while maintaining sufficient water solubility for biological testing. These characteristics make it an attractive candidate for lead optimization programs in pharmaceutical development.

Recent publications highlight the compound's potential in addressing antibiotic resistance, a major global health concern. The thiazole core has shown activity against resistant bacterial strains, and modifications at the 4-position (cyclohexylmethyl group) may enhance this effect. This connection to pressing medical challenges increases its relevance in current scientific discourse and search queries related to novel antimicrobial agents.

From a synthetic chemistry perspective, CAS 1501854-55-2 serves as a valuable intermediate for constructing more complex molecules. The bromo substituent at position 5 allows for various cross-coupling reactions, while the carboxylic acid functionality enables amide bond formation or esterification. These features make it particularly useful in combinatorial chemistry and high-throughput screening applications.

The compound's stability profile has been another area of investigation. Preliminary studies suggest that 5-Bromo-4-(cyclohexylmethyl)thiazole-2-carboxylic acid maintains integrity under standard storage conditions, an important consideration for research applications. Its thermal stability has been confirmed through differential scanning calorimetry, with decomposition temperatures exceeding 200°C.

In material science applications, the thiazole moiety of this compound contributes to interesting electronic properties. Researchers exploring organic semiconductors and photovoltaic materials have shown interest in similar structures due to their electron-transport characteristics. This expands the potential applications beyond pharmaceuticals into emerging technologies like flexible electronics and energy storage solutions.

Market analysis indicates growing demand for specialty chemicals like 5-Bromo-4-(cyclohexylmethyl)thiazole-2-carboxylic acid. The compound's price and availability fluctuate based on research trends, with current production primarily serving the pharmaceutical and agrochemical sectors. Suppliers typically offer it in research quantities (milligram to gram scale) with purity levels exceeding 95%, suitable for most laboratory applications.

Quality control aspects of CAS 1501854-55-2 involve rigorous analytical characterization. Standard quality assessments include HPLC purity determination, ¹H/¹³C NMR verification, and mass spectrometry confirmation. These analytical procedures ensure researchers receive material meeting published specifications, crucial for reproducible experimental results in drug discovery programs.

The environmental and safety profile of 5-Bromo-4-(cyclohexylmethyl)thiazole-2-carboxylic acid has been evaluated according to standard protocols. While not classified as hazardous under current regulations, proper laboratory handling procedures are recommended. Material safety data sheets provide detailed guidance on storage conditions (typically 2-8°C under inert atmosphere) and personal protective equipment requirements.

Future research directions for this compound likely include exploration of its structure-activity relationships in various biological targets. Computational chemistry approaches, particularly molecular docking studies, may help identify potential therapeutic applications. The compound's modular structure also makes it suitable for parallel synthesis approaches to generate focused libraries for biological screening.

In conclusion, 5-Bromo-4-(cyclohexylmethyl)thiazole-2-carboxylic acid (CAS No. 1501854-55-2) represents a versatile chemical building block with significant potential across multiple research domains. Its unique combination of structural features, synthetic accessibility, and biological relevance positions it as a valuable tool for scientists working at the intersection of chemistry and life sciences. As research into heterocyclic compounds continues to expand, this molecule will likely play an increasingly important role in both academic and industrial settings.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)