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  Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
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  Kathrin Kutlescha,Rhett Kempe New J. Chem., 2010,34, 1954-1960
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• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides Purine deoxyribonucleotides Purine deoxyribonucleoside monophosphates
• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Catalysts and Inorganic Chemicals Inorganic Compounds Salt

Comprehensive Guide to 2'-Deoxyinosine 5'-Monophosphate Disodium Salt (CAS No. 14999-52-1)

2'-Deoxyinosine 5'-Monophosphate Disodium Salt (CAS No. 14999-52-1) is a biologically significant nucleotide derivative widely used in molecular biology, diagnostics, and pharmaceutical research. This compound, often abbreviated as dIMP-Na2, plays a crucial role in DNA synthesis and repair mechanisms. Its unique structure and properties make it a valuable tool for researchers exploring genetic engineering, antiviral therapies, and diagnostic assays.

The chemical formula of 2'-Deoxyinosine 5'-Monophosphate Disodium Salt is C₁₀H₁₁N₄O₇P·2Na, with a molecular weight of 368.17 g/mol. As a sodium salt of deoxyinosine monophosphate, it exhibits excellent water solubility, making it ideal for in vitro applications. The compound's stability under physiological conditions has garnered significant attention in the development of novel PCR reagents and next-generation sequencing technologies.

Recent advancements in genetic research have increased the demand for high-purity nucleotide analogs like 2'-Deoxyinosine 5'-Monophosphate Disodium Salt. Researchers are particularly interested in its potential applications in CRISPR-Cas9 gene editing systems, where modified nucleotides can enhance editing efficiency. The compound's compatibility with various enzymatic reactions makes it a versatile component in synthetic biology workflows.

In the pharmaceutical industry, dIMP-Na2 has shown promise as a precursor for antiviral drug development. Studies suggest its derivatives may inhibit viral polymerase activity, offering potential therapeutic avenues for RNA viruses. This connection to infectious disease research has become particularly relevant in the post-pandemic era, where scientists are actively exploring novel antiviral strategies.

The analytical characterization of 2'-Deoxyinosine 5'-Monophosphate Disodium Salt typically involves HPLC and mass spectrometry techniques to ensure purity and identity. Quality control specifications for research-grade material generally require ≥95% purity, with strict limits on endotoxin levels for cell culture applications. These stringent standards reflect the compound's importance in sensitive molecular biology experiments.

From a commercial perspective, the global market for research nucleotides has grown steadily, driven by expanding applications in precision medicine and diagnostic test development. Manufacturers of 2'-Deoxyinosine 5'-Monophosphate Disodium Salt have responded by improving production processes to meet the increasing demand for high-quality, batch-consistent materials. This trend aligns with the broader shift toward reproducible research in life sciences.

Storage and handling recommendations for CAS 14999-52-1 typically suggest keeping the compound at -20°C in a dry environment to maintain stability. Proper storage becomes particularly important for long-term projects in genome sequencing or biobanking applications. Many suppliers now offer customized packaging options to accommodate different research scales, from milligram quantities for preliminary studies to bulk orders for large-scale production.

Emerging applications of 2'-Deoxyinosine 5'-Monophosphate Disodium Salt in cancer research have attracted significant scientific interest. Some studies investigate its potential as a biomarker or its role in nucleotide metabolism pathways that are often dysregulated in tumor cells. These developments position the compound at the intersection of oncology research and molecular diagnostics, two rapidly evolving fields with substantial research investment.

For researchers working with dIMP-Na2, understanding its spectral properties is essential. The compound exhibits characteristic UV absorption at 260 nm (ε = 12,400 M^-1cm^-1), a feature commonly utilized in spectrophotometric quantification methods. This property becomes particularly valuable in experiments requiring precise nucleotide concentration measurements, such as primer extension assays or DNA library preparation.

The regulatory landscape for research chemicals like 2'-Deoxyinosine 5'-Monophosphate Disodium Salt continues to evolve, with increasing emphasis on documentation and traceability. Reputable suppliers now provide comprehensive certificates of analysis and material safety data sheets to comply with international laboratory standards. This documentation is particularly crucial for researchers preparing submissions to regulatory agencies or publishing in high-impact journals.

Looking ahead, the applications of CAS 14999-52-1 are expected to expand further with advancements in single-cell genomics and spatial transcriptomics. These cutting-edge technologies often require specialized nucleotide analogs to enable sensitive detection methods. The compound's established safety profile and well-characterized properties position it well for adoption in these emerging research domains.

In educational settings, 2'-Deoxyinosine 5'-Monophosphate Disodium Salt serves as an excellent tool for teaching fundamental concepts in molecular genetics and enzymology. Its relatively stable nature compared to some other nucleotide derivatives makes it suitable for undergraduate laboratory experiments demonstrating DNA polymerization or nucleotide metabolism pathways.

The synthesis and purification of dIMP-Na2 have seen technological improvements in recent years, with many manufacturers adopting green chemistry principles to reduce environmental impact. These process optimizations not only improve sustainability but also enhance product consistency—a critical factor for researchers requiring reproducible results across experiments and between laboratories.

For those sourcing 2'-Deoxyinosine 5'-Monophosphate Disodium Salt, understanding regional supply chain dynamics has become increasingly important. The growing emphasis on research continuity has led many institutions to establish diversified supplier networks, ensuring access to critical reagents like CAS 14999-52-1 even during global disruptions. This strategic approach to procurement reflects the compound's essential role in modern life science research.

• 30918-54-8(Polyinosinic Acid (90%))
• 4691-65-0(Disodium 5'-inosinate)
• 38966-29-9(5'-Inosinicacid, calcium salt (1:?))
• 15923-57-6(5'-Inosinic acid,dibutyl ester (8CI,9CI))
• 25249-22-3(Inosinic acid)
• 14999-51-0(5'-Inosinic acid, sodium salt)
• 3249-92-1(5'-Inosinic acid,barium salt (1:1) (8CI,9CI))
• 352195-40-5(Inosine 5'-Monophosphate Disodium Salt Hydrate)
• 131-99-7(5'-Inosinic acid)
• 141673-59-8(5'-Inosinic acid,monomethyl ester (9CI))