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  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 2. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 3. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
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• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Prenol lipids Menthane monoterpenoids
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Prenol lipids Monoterpenoids Menthane monoterpenoids

Comprehensive Overview of 3-(4-tert-Butylcyclohexyl)piperidine (CAS No. 1499819-64-5): Properties, Applications, and Industry Insights

3-(4-tert-Butylcyclohexyl)piperidine (CAS No. 1499819-64-5) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research due to its unique structural features. This compound combines a piperidine ring with a 4-tert-butylcyclohexyl moiety, offering a versatile scaffold for drug discovery and material science applications. Its molecular formula, C₁₅H₂₉N, and precise stereochemistry make it a valuable intermediate in synthesizing bioactive molecules.

In recent years, the demand for high-purity cyclic amines like 3-(4-tert-Butylcyclohexyl)piperidine has surged, driven by advancements in central nervous system (CNS) drug development and catalysis. Researchers frequently search for "piperidine derivatives in medicinal chemistry" or "tert-butylcyclohexyl compounds solubility," reflecting its relevance in optimizing drug pharmacokinetics. The compound's lipophilic tert-butyl group enhances membrane permeability, a critical factor in blood-brain barrier penetration—a hot topic in neurodegenerative disease research.

The synthesis of 1499819-64-5 typically involves multi-step organic reactions, including hydrogenation and reductive amination, with yields optimized through modern flow chemistry techniques. Analytical characterization via NMR spectroscopy and HPLC-MS confirms its structural integrity, while computational studies (e.g., molecular docking) explore its potential as a ligand for G-protein-coupled receptors. These methodologies align with the growing interest in "AI-driven molecular design" and "green chemistry alternatives," as industries seek sustainable synthetic routes.

Beyond pharmaceuticals, 3-(4-tert-Butylcyclohexyl)piperidine finds niche applications in advanced material science, particularly in designing liquid crystal displays (LCDs) and polymeric coatings. Its rigid cyclohexyl-piperidine backbone contributes to thermal stability, a property highly sought after in "high-performance polymers"—a trending search term among material engineers. Regulatory compliance with REACH and FDA guidelines further underscores its industrial viability.

Future research directions for CAS No. 1499819-64-5 may focus on its enantioselective synthesis, given the rising demand for chiral building blocks in asymmetric catalysis. With the compound's patent landscape evolving, stakeholders monitor "IP protection strategies for specialty chemicals" to capitalize on its commercial potential. Collaborative efforts between academia and industry continue to unlock novel applications, reinforcing its role in next-generation bioactive materials.

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