Cas no 149978-42-7 (1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine)

1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine is a fluorinated pyrazole derivative with significant utility in pharmaceutical and agrochemical research. Its trifluoromethyl group enhances metabolic stability and lipophilicity, making it a valuable intermediate in the synthesis of bioactive compounds. The amine functionality at the 3-position allows for further derivatization, enabling the development of novel heterocyclic structures. This compound exhibits favorable physicochemical properties, including moderate solubility in organic solvents, facilitating its use in diverse synthetic applications. Its structural features contribute to improved binding affinity in target interactions, particularly in the design of enzyme inhibitors and receptor modulators. The compound is synthesized under controlled conditions to ensure high purity and consistency for research purposes.
1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine structure
149978-42-7 structure
Product Name:1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine
CAS No:149978-42-7
MF:C5H6F3N3
MW:165.116450786591
MDL:MFCD09701818
CID:1084589
PubChem ID:22912798
Update Time:2025-05-19

1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine Chemical and Physical Properties

Names and Identifiers

    • 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine
    • 1-methyl-5-(trifluoromethyl)pyrazol-3-amine
    • 1-methyl-5-(trifluoromethyl)pyrazole-3-ylamine
    • 1-methyl-5-trifluoromethyl-1H-pyrazol-3-ylamine
    • 3-amino-1-methyl-5-trifluoromethylpyrazole
    • SBB025292
    • STK352237
    • SureCN1012284
    • 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-
    • 3-amino-5-trifluoromethyl-N-methyl pyrazole
    • 3-Amino-1-methyl-5-(trifluoromethyl)-1H-pyrazole
    • 1H-Pyrazol-3-amine, 1-methyl-5-(trifluoromethyl)-
    • XIVVMPWSYHAGFP-UHFFFAOYSA-N
    • 3-amino-1-methyl5-trifluoromethylpyrazole
    • 3-amino-1-methyl-5-trifluoromethylpyr
    • EN300-100132
    • 5-(Trifluoromethyl)-1-methyl-1H-pyrazol-3-amine
    • FS-2343
    • SY128198
    • SCHEMBL1012284
    • Z1198221261
    • AMY6421
    • MFCD09701818
    • A849559
    • 1-Methyl-5-(Trifluoromethyl)-3-Aminopyrazole
    • 3-Amino-1-methyl-5-(trifluoromethyl)pyrazole
    • DA-29160
    • DTXSID30628877
    • ZFA97842
    • 149978-42-7
    • CS-0054563
    • AKOS005167840
    • MDL： MFCD09701818
    • Inchi： 1S/C5H6F3N3/c1-11-3(5(6,7)8)2-4(9)10-11/h2H,1H3,(H2,9,10)
    • InChI Key： XIVVMPWSYHAGFP-UHFFFAOYSA-N
    • SMILES： FC(C1=CC(N)=NN1C)(F)F

Computed Properties

  • Exact Mass: 165.05138169g/mol
  • Monoisotopic Mass: 165.05138169g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 0
  • Complexity: 146
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 43.8
  • XLogP3: 0.8

Experimental Properties

  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 227.9±40.0 °C at 760 mmHg
  • Flash Point: 91.6±27.3 °C
  • Vapor Pressure: 0.1±0.5 mmHg at 25°C

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Suzhou Senfeida Chemical Co., Ltd
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(CAS:149978-42-7)1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine
Order Number:sfd768
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:32
Price ($):discuss personally

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1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine: A Comprehensive Overview

1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine, also known by its CAS number 149978-42-7, is a versatile and intriguing compound that has garnered significant attention in the fields of organic chemistry, pharmacology, and materials science. This compound belongs to the class of pyrazole derivatives, which are well-known for their diverse biological activities and applications. The structure of 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine is characterized by a pyrazole ring substituted with a methyl group at position 1, a trifluoromethyl group at position 5, and an amine group at position 3. These substituents contribute to its unique chemical properties and reactivity.

The synthesis of 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine has been extensively studied, with researchers exploring various methodologies to optimize its production. Recent advancements in catalytic systems and green chemistry have enabled more efficient and environmentally friendly routes for its synthesis. For instance, the use of microwave-assisted synthesis has been reported to significantly reduce reaction times while maintaining high yields. Such innovations highlight the compound's potential for large-scale industrial applications.

In terms of biological activity, 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine has demonstrated promising properties in several therapeutic areas. Studies have shown that it exhibits potent anti-inflammatory and antioxidant effects, making it a potential candidate for the development of novel drugs targeting inflammatory diseases. Additionally, its ability to inhibit certain enzymes associated with neurodegenerative disorders has been explored in recent research, further underscoring its therapeutic potential.

The electronic properties of 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine make it an attractive candidate for applications in materials science. Its conjugated system allows for efficient electron delocalization, which is advantageous in the design of organic semiconductors and optoelectronic devices. Recent studies have investigated its use in organic light-emitting diodes (OLEDs) and photovoltaic cells, where it has shown promising performance metrics such as high luminous efficiency and excellent charge transport properties.

The environmental impact of 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine is another area of active research. As concerns about chemical pollution continue to grow, understanding the fate and toxicity of this compound in natural ecosystems is crucial. Recent studies have focused on its biodegradation pathways and potential accumulation in soil and water systems. These investigations aim to ensure that its use aligns with sustainable practices and minimizes adverse environmental effects.

In conclusion, 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine, with its unique chemical structure and diverse applications, represents a significant advancement in modern chemistry. Its role in drug discovery, materials science, and environmental studies highlights its multifaceted importance. As research continues to uncover new insights into its properties and potential uses, this compound is poised to make even greater contributions to various scientific disciplines.

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Suzhou Senfeida Chemical Co., Ltd
(CAS:149978-42-7)1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-amine
sfd768
Purity:99.9%
Quantity:200kg
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