• 1. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 2. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 3. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 4. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 5. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acids

Comprehensive Overview of 2-[(3,4-Dichlorobenzyl)oxy]benzoic Acid (CAS No. 149894-43-9): Properties, Applications, and Industry Insights

2-[(3,4-Dichlorobenzyl)oxy]benzoic Acid (CAS No. 149894-43-9) is a specialized organic compound with a molecular formula of C₁₄H₁₀Cl₂O₃. This benzoic acid derivative is characterized by its unique dichlorobenzyl ether functional group, which contributes to its distinct chemical and physical properties. The compound has garnered significant attention in pharmaceutical and agrochemical research due to its potential as a bioactive intermediate.

In recent years, the demand for high-purity organic intermediates like 2-[(3,4-Dichlorobenzyl)oxy]benzoic Acid has surged, driven by advancements in drug discovery and crop protection formulations. Researchers frequently search for "synthesis methods for CAS 149894-43-9" or "applications of dichlorobenzyloxy benzoic acid derivatives," reflecting the compound's growing relevance in green chemistry and sustainable manufacturing processes.

The compound's molecular structure features a benzyl ether linkage that enhances its stability while maintaining reactivity for further functionalization. This makes it particularly valuable for developing targeted therapeutic agents and specialty chemicals. Analytical techniques such as HPLC, NMR spectroscopy, and mass spectrometry are commonly employed to verify the purity and structural integrity of CAS 149894-43-9, especially when used in GMP-compliant production.

From an industrial perspective, 2-[(3,4-Dichlorobenzyl)oxy]benzoic Acid aligns with current trends in precise molecular design and structure-activity relationship optimization. Manufacturers focusing on custom synthesis services often highlight this compound's versatility in creating patented chemical entities for various applications. The rise of computational chemistry tools has further accelerated research into its potential pharmacophore features and metabolic pathways.

Environmental considerations surrounding chlorinated compounds have led to increased interest in the biodegradation profile of 149894-43-9. Recent studies explore its ecotoxicological impact and green synthesis alternatives, addressing concerns about persistent organic pollutants. This aligns with global initiatives for safer chemical alternatives while maintaining functional efficacy in end-use applications.

The compound's crystalline properties and solubility characteristics make it suitable for various formulation approaches, particularly in developing controlled-release systems. Pharmaceutical scientists frequently investigate its potential as a prodrug moiety or formulation enhancer, capitalizing on its balanced lipophilicity profile and hydrogen bonding capacity.

Quality control protocols for 2-[(3,4-Dichlorobenzyl)oxy]benzoic Acid emphasize strict impurity profiling to meet regulatory standards for human health products and agricultural inputs. The compound's thermal stability and compatibility with common excipients are frequently evaluated through accelerated stability studies and compatibility testing.

Emerging research directions include exploring the compound's utility in material science applications, particularly as a monomer for specialized polymers or as a surface modification agent. Its aromatic backbone and functional group diversity offer numerous possibilities for covalent conjugation in advanced material systems.

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