• 1. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
• 2. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
• 3. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 4. Fe3O4 nanoclusters highly dispersed on a porous graphene support as an additive for improving the hydrogen storage properties of LiBH4?
  Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361
• 5. Fe3O4 nanosphere@microporous organic networks: enhanced anode performances in lithium ion batteries through carbonization?
  Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726

• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

Professional Introduction to trans-4-(Benzyloxycarbonylamino)cyclohexylamine (CAS No. 149423-77-8)

trans-4-(Benzyloxycarbonylamino)cyclohexylamine, with the CAS number 149423-77-8, is a specialized organic compound that has garnered significant attention in the field of pharmaceutical research and development. This compound belongs to the class of amino acid derivatives, characterized by its unique structural and functional properties. The presence of a benzyloxycarbonyl (Boc) group and a cyclohexylamine moiety imparts distinct reactivity and stability, making it a valuable intermediate in the synthesis of various bioactive molecules.

The benzyloxycarbonyl group is a well-known protecting group in peptide chemistry, widely employed to prevent the deprotection of amino groups during synthetic procedures. This feature makes trans-4-(Benzyloxycarbonylamino)cyclohexylamine particularly useful in the construction of peptide mimetics and other peptidomimetic drugs. The cyclohexylamine portion contributes to the compound's solubility and bioavailability, which are critical factors in drug design and formulation.

In recent years, there has been a surge in research focused on developing novel therapeutic agents that target neurological disorders, such as Alzheimer's disease and Parkinson's disease. The cyclohexylamine backbone is known to enhance the blood-brain barrier penetration of drugs, a property that has been leveraged in the design of neuroprotective agents. Furthermore, the Boc-protected amino group allows for selective modification during synthetic pathways, enabling researchers to fine-tune the pharmacological properties of their target molecules.

One of the most compelling applications of trans-4-(Benzyloxycarbonylamino)cyclohexylamine is in the field of enzyme inhibition. The compound's structural framework is conducive to binding with various enzymatic targets, making it a promising scaffold for developing inhibitors of therapeutic interest. For instance, studies have demonstrated its potential in inhibiting enzymes involved in inflammation and pain signaling pathways. These findings have opened up new avenues for the development of anti-inflammatory and analgesic drugs.

The synthesis of trans-4-(Benzyloxycarbonylamino)cyclohexylamine involves multi-step organic reactions that require precise control over reaction conditions. The use of advanced catalytic systems and green chemistry principles has enabled more efficient and environmentally friendly synthetic routes. These advancements not only improve yield but also reduce waste, aligning with the growing emphasis on sustainable chemical practices.

Recent breakthroughs in computational chemistry have further enhanced the utility of trans-4-(Benzyloxycarbonylamino)cyclohexylamine. Molecular modeling studies have provided insights into its interaction with biological targets at an atomic level, facilitating the rational design of more effective drug candidates. These computational approaches are complemented by experimental validation, ensuring that the synthesized compounds exhibit the desired pharmacological properties.

The role of trans-4-(Benzyloxycarbonylamino)cyclohexylamine in drug discovery extends beyond its use as an intermediate. It has also been explored as a building block for designing novel molecular entities with unique pharmacokinetic profiles. For example, modifications to its structure have led to compounds with improved metabolic stability and reduced toxicity, key factors in successful drug development.

In conclusion, trans-4-(Benzyloxycarbonylamino)cyclohexylamine (CAS No. 149423-77-8) represents a significant advancement in pharmaceutical chemistry. Its unique structural features and versatile reactivity make it an indispensable tool in the synthesis of bioactive molecules targeting various diseases. As research continues to uncover new applications for this compound, its importance in drug development is set to grow even further.

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