Cas no 14861-17-7 (4-(2,4-Dichlorophenoxy)aniline hydrochloride)

4-(2,4-Dichlorophenoxy)aniline hydrochloride is a chlorinated aromatic amine derivative with applications in organic synthesis and pharmaceutical research. Its structure features a phenoxy linkage and an aniline group, making it a versatile intermediate for constructing more complex molecules. The hydrochloride salt form enhances stability and solubility, facilitating handling and storage. This compound is particularly useful in the development of agrochemicals and bioactive compounds due to its dichlorophenoxy moiety, which can influence biological activity. High purity and consistent quality ensure reliable performance in synthetic applications. Proper handling precautions are advised due to its reactive amine functionality.
4-(2,4-Dichlorophenoxy)aniline hydrochloride structure
14861-17-7 structure
Product Name:4-(2,4-Dichlorophenoxy)aniline hydrochloride
CAS No:14861-17-7
MF:C12H9Cl2NO
MW:254.111961126328
MDL:MFCD00459612
CID:49944
PubChem ID:26940
Update Time:2025-10-19

4-(2,4-Dichlorophenoxy)aniline hydrochloride Chemical and Physical Properties

Names and Identifiers

    • 4-(2,4-Dichlorophenoxy)aniline
    • 2,4-Dichloro-4'-aminodiphenyl ether
    • 2',4'-Dichloro-4-aminobiphenyl ether
    • 2,4-Dichlorophenyl p-aminophenyl ether
    • 4-amino-2',4'-dichlorodiphenyl ether
    • Aminonitrofen
    • EINECS 238-932-7
    • p-amino-2',4'-dichlorodiphenyl ether
    • AMINOFEN
    • p-(2,4-Dichlorophenoxy)aniline
    • p-(2,4-dichlorophenoxy)-anilin
    • 4-(2,4-dichlorophenoxy)benzenamine
    • 4-(2,4-dichlorophenoxy)-benzenamin
    • 2’,4’-dichloro-4-aminobiphenylether
    • 2,4-DICHLORO-4'-AMINODIPHENYL ESTER
    • AS-10510
    • A26460
    • 2,4-dichloro-4'-aminodiphenyl ether, AldrichCPR
    • 5-IODO-5-DEOXYADENOSINE
    • SB81567
    • Amino-nitrofen
    • 4-(2,4-dichloro-phenoxy)aniline
    • AKOS000215095
    • Benzenamine, 4-(2,4-dichlorophenoxy)-
    • UNII-R41F3KF27M
    • Q27287769
    • CS-0318510
    • NS00021675
    • 4-(2,4-Dichlorophenoxy)-benzenamin;4-(2,4-dichlorophenoxy)benzenamine;p-(2,4-Dichlorophenoxy)-anilin;4-Amino-2',4'-dichlorodiphenyl ether
    • 14861-17-7
    • MFCD00459612
    • SCHEMBL554810
    • R41F3KF27M
    • DTXSID3065825
    • ANILINE, p-(2,4-DICHLOROPHENOXY)-
    • 2,4-DICHLORO-4/'-AMINODIPHENYL ETHER
    • CCRIS 8005
    • 2,4-Dichloro-1-(4-aminophenoxy)benzene
    • MolPort-003-784-978
    • 4-Amino-2',4'-dichloro-diphenyl ether
    • ALBB-031696
    • STK650521
    • 4-(2,4-Dichlorophenoxy)aniline hydrochloride
    • MDL： MFCD00459612
    • Inchi： 1S/C12H9Cl2NO/c13-8-1-6-12(11(14)7-8)16-10-4-2-9(15)3-5-10/h1-7H,15H2
    • InChI Key： RWDOREOERSVIRK-UHFFFAOYSA-N
    • SMILES： ClC1C=C(C=CC=1OC1C=CC(=CC=1)N)Cl

Computed Properties

  • Exact Mass: 253.00600
  • Monoisotopic Mass: 253.006119
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 16
  • Rotatable Bond Count: 2
  • Complexity: 219
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.8
  • Topological Polar Surface Area: 35.2

Experimental Properties

  • Density: 1.364
  • Boiling Point: 359.8 °C at 760 mmHg
  • Flash Point: 171.4 °C
  • Refractive Index: 1.635
  • PSA: 35.25000
  • LogP: 4.94910

4-(2,4-Dichlorophenoxy)aniline hydrochloride Security Information

  • Hazard Category Code： 22
  • Hazardous Material Identification： Xn

4-(2,4-Dichlorophenoxy)aniline hydrochloride Customs Data

  • HS CODE：2922299090
  • Customs Data：

    China Customs Code:

    2922299090

    Overview:

    2922299090. Other amino groups(naphthol\phenol)And ether\Esters [including their salts, Except those containing more than one oxygen-containing group]. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared

    Summary:

    2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

4-(2,4-Dichlorophenoxy)aniline hydrochloride Pricemore >>

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4-(2,4-Dichlorophenoxy)aniline hydrochloride Related Literature

Additional information on 4-(2,4-Dichlorophenoxy)aniline hydrochloride

Recent Advances in the Study of 4-(2,4-Dichlorophenoxy)aniline Hydrochloride (CAS: 14861-17-7)

4-(2,4-Dichlorophenoxy)aniline hydrochloride (CAS: 14861-17-7) is a chemical compound of significant interest in the field of chemical biology and pharmaceutical research. This compound, characterized by its dichlorophenoxy and aniline functional groups, has been the subject of recent investigations due to its potential applications in drug development and agrochemical formulations. The hydrochloride salt form enhances its solubility and stability, making it a viable candidate for further pharmacological studies.

Recent studies have focused on the synthesis and characterization of 4-(2,4-Dichlorophenoxy)aniline hydrochloride, with particular emphasis on its biological activity. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its inhibitory effects on specific enzyme pathways involved in inflammatory responses, suggesting potential therapeutic applications for autoimmune diseases. The study utilized high-throughput screening assays to evaluate the compound's efficacy, revealing promising IC50 values in the nanomolar range.

In addition to its pharmacological potential, 4-(2,4-Dichlorophenoxy)aniline hydrochloride has also been investigated for its role in agrochemical applications. Research published in Pest Management Science (2024) highlighted its herbicidal activity against broadleaf weeds, with mechanisms involving disruption of auxin-mediated growth pathways. The compound's selectivity and low environmental persistence make it a candidate for sustainable herbicide development.

The structural elucidation of 4-(2,4-Dichlorophenoxy)aniline hydrochloride has been advanced through crystallographic studies. A recent X-ray diffraction analysis provided detailed insights into its molecular conformation and intermolecular interactions, which are critical for understanding its binding affinity to biological targets. These findings were published in Acta Crystallographica Section E (2023), contributing to the rational design of derivatives with enhanced properties.

Despite these advancements, challenges remain in optimizing the compound's pharmacokinetic profile. A 2024 review in Bioorganic & Medicinal Chemistry Letters discussed strategies to improve its bioavailability and reduce off-target effects, including structural modifications and formulation technologies. These efforts are essential for translating preclinical findings into clinical applications.

In conclusion, 4-(2,4-Dichlorophenoxy)aniline hydrochloride (CAS: 14861-17-7) represents a versatile compound with dual applications in medicine and agriculture. Ongoing research aims to harness its full potential through multidisciplinary approaches, combining synthetic chemistry, structural biology, and pharmacological evaluations. Future studies are expected to explore its mechanisms of action in greater depth and assess its safety profile in vivo.

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