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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines
• Other Chemical Reagents Derivatization Reagents
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

(2,6-Dichloropyridin-3-yl)boronic Acid: A Comprehensive Overview

(2,6-Dichloropyridin-3-yl)boronic acid, identified by the CAS number 148493-34-9, is a significant compound in the field of organic chemistry and materials science. This compound has garnered attention due to its unique chemical properties and versatile applications in various research domains. In this article, we delve into the structural characteristics, chemical properties, synthesis methods, and recent advancements in its applications.

The molecular structure of (2,6-dichloropyridin-3-yl)boronic acid consists of a pyridine ring substituted with two chlorine atoms at the 2 and 6 positions, along with a boronic acid group at the 3 position. This configuration imparts the compound with distinct electronic properties, making it highly suitable for cross-coupling reactions—a cornerstone in modern organic synthesis. Recent studies have highlighted its role in Suzuki-Miyaura coupling reactions, where it serves as an efficient boron-based reagent for forming carbon-carbon bonds.

One of the most notable advancements involving CAS No. 148493-34-9 is its application in drug discovery and development. Researchers have utilized this compound to synthesize bioactive molecules with potential therapeutic effects. For instance, a study published in the Journal of Medicinal Chemistry demonstrated that derivatives of (2,6-dichloropyridin-3-yl)boronic acid exhibit promising anti-cancer activity by targeting specific oncogenic pathways.

In addition to its role in pharmaceuticals, this compound has found applications in materials science, particularly in the development of advanced materials such as organic semiconductors and optoelectronic devices. The unique electronic properties of (2,6-dichloropyridin-3-yl)boronic acid enable it to act as a building block for constructing high-performance materials with tailored functionalities.

The synthesis of CAS No. 148493-34-9 typically involves multi-step processes that require precise control over reaction conditions to ensure high yield and purity. Recent advancements in catalytic methods have streamlined the synthesis process, making it more efficient and scalable for industrial applications.

In conclusion, (2,6-dichloropyridin-3-yl)boronic acid continues to be a focal point in chemical research due to its diverse applications and unique properties. As ongoing studies uncover new potential uses and improved synthesis techniques emerge, this compound is poised to play an even more significant role in advancing various scientific fields.

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