Cas no 148461-13-6 (Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)-)

Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)-, is a chiral oxazole-based ligand with a diphenylphosphino substituent, offering strong coordination capabilities for transition metals. Its stereospecific (4S) configuration makes it valuable in asymmetric catalysis, particularly in enantioselective transformations. The ligand’s rigid oxazole backbone enhances stability, while the phosphine group facilitates efficient metal binding, improving catalytic activity and selectivity. The phenylmethyl substitution further modulates steric and electronic properties, optimizing performance in cross-coupling and hydrogenation reactions. This compound is well-suited for applications requiring high enantiomeric excess, making it a preferred choice in pharmaceutical and fine chemical synthesis.
Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)- structure
148461-13-6 structure
Product Name:Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)-
CAS No:148461-13-6
MF:C28H24NOP
MW:421.470027923584
MDL:MFCD30541667
CID:1319684
PubChem ID:10875716
Update Time:2025-11-02

Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)- Chemical and Physical Properties

Names and Identifiers

    • Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)-
    • (S)-Bn-PHOX
    • (S)-4-benzyl-2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole
    • (S)-4-benzyl-2-(2-(diphenylphosphanyl)phenyl)-4,5-dihydrooxazole
    • (4S)-2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylMethyl)-Oxazole
    • SCHEMBL5606047
    • CS-0029496
    • 148461-13-6
    • AKOS030528929
    • AS-73466
    • YFA46113
    • Oxazole, 2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)-
    • (4S)-4-benzyl-2-[2-(diphenylphosphanyl)phenyl]-4,5-dihydro-1,3-oxazole
    • [2-[(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl]phenyl]-diphenylphosphane
    • (4S)-2-[2-(Diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)oxazole,99%e.e.
    • MDL： MFCD30541667
    • Inchi： 1S/C28H24NOP/c1-4-12-22(13-5-1)20-23-21-30-28(29-23)26-18-10-11-19-27(26)31(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-19,23H,20-21H2/t23-/m0/s1
    • InChI Key： PXKBZZCPBWBSKT-QHCPKHFHSA-N
    • SMILES： P(C1C=CC=CC=1)(C1C=CC=CC=1)C1=CC=CC=C1C1=N[C@H](CO1)CC1C=CC=CC=1

Computed Properties

  • Exact Mass: 421.15972
  • Monoisotopic Mass: 421.159551387g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 31
  • Rotatable Bond Count: 6
  • Complexity: 556
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 6.1
  • Topological Polar Surface Area: 21.6?2

Experimental Properties

  • PSA: 21.59

Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)- Pricemore >>

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Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)- Suppliers

Amadis Chemical Company Limited
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(CAS:148461-13-6)Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)-
Order Number:A1000210
Stock Status:in Stock
Quantity:1g/5g
Purity:99%
Pricing Information Last Updated:Thursday, 29 August 2024 14:56
Price ($):296.0/1265.0

Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)- Related Literature

Additional information on Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)-

Comprehensive Overview of Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)- (CAS No. 148461-13-6)

The compound Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)- (CAS No. 148461-13-6) is a highly specialized chiral oxazole derivative with significant applications in asymmetric synthesis and catalysis. Its unique structure, featuring a diphenylphosphino group and a phenylmethyl substituent, makes it a valuable ligand in transition-metal-catalyzed reactions. Researchers and chemists are increasingly interested in this compound due to its potential in pharmaceutical intermediates and fine chemical synthesis.

In recent years, the demand for chiral auxiliaries and ligands like Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)- has surged, driven by advancements in enantioselective catalysis. This compound's ability to induce high stereoselectivity in reactions such as hydrogenation and cross-coupling has made it a topic of interest in academic and industrial research. Users often search for "chiral oxazole derivatives" or "asymmetric synthesis ligands," reflecting the growing focus on sustainable and efficient synthetic methodologies.

The diphenylphosphino moiety in Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)- plays a critical role in coordinating with transition metals like palladium, rhodium, and iridium. This coordination enhances the metal's catalytic activity, enabling reactions under milder conditions with higher yields. Such properties align with the current trend toward "green chemistry" and "atom economy," which are frequently searched terms in the context of sustainable chemical processes.

Another notable feature of this compound is its (4S)- configuration, which ensures enantiomeric purity in catalytic applications. This aspect is particularly relevant to the pharmaceutical industry, where the demand for "enantiopure compounds" and "chiral drug synthesis" continues to rise. The compound's stability and compatibility with various reaction conditions further contribute to its versatility in organic synthesis.

Beyond its catalytic applications, Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)- is also explored in material science, particularly in the development of "advanced functional materials." Its phosphine-containing structure offers potential in designing luminescent materials or metal-organic frameworks (MOFs), topics that are gaining traction in scientific literature and online searches.

In summary, Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)- (CAS No. 148461-13-6) represents a cutting-edge tool in modern chemistry, bridging the gap between academic research and industrial applications. Its relevance to "asymmetric catalysis," "pharmaceutical intermediates," and "sustainable synthesis" ensures its continued prominence in scientific discourse and search engine queries.

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Amadis Chemical Company Limited
(CAS:148461-13-6)Oxazole,2-[2-(diphenylphosphino)phenyl]-4,5-dihydro-4-(phenylmethyl)-, (4S)-
A1000210
Purity:99%/99%
Quantity:1g/5g
Price ($):296.0/1265.0
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