• 1. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 2. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 3. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 4. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 5. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines

Comprehensive Guide to 3-Chloro-2-fluoropyridine (CAS No. 1480-64-4): Properties, Applications, and Industry Insights

3-Chloro-2-fluoropyridine (CAS No. 1480-64-4) is a halogenated pyridine derivative that has garnered significant attention in pharmaceutical and agrochemical research. This heterocyclic compound, characterized by its chloro and fluoro substituents, serves as a versatile building block in organic synthesis. Its molecular formula, C₅H₃ClFN, and unique structural features make it invaluable for designing advanced materials and bioactive molecules.

In recent years, the demand for fluorinated pyridines like 3-Chloro-2-fluoropyridine has surged due to their role in drug discovery. Researchers highlight its utility in creating kinase inhibitors and antibacterial agents, aligning with the global focus on antibiotic resistance. A 2023 study published in the Journal of Medicinal Chemistry emphasized how fluoropyridines enhance metabolic stability in drug candidates—a key concern for pharmaceutical developers.

From an industrial perspective, CAS 1480-64-4 is critical for synthesizing crop protection chemicals. Its reactivity enables the introduction of fluorine into agrochemicals, improving their efficacy against resistant pests. This aligns with the growing trend of sustainable agriculture, where users frequently search for "eco-friendly fluorinated pesticides" or "halogenated pyridine applications."

The compound’s physical properties—including a boiling point of 180–182°C and solubility in organic solvents—make it suitable for cross-coupling reactions. Laboratories often employ it in Suzuki-Miyaura or Buchwald-Hartwig reactions, as noted in patents from leading chemical manufacturers. These processes are pivotal for creating electronic materials, another hot topic linked to searches for "fluoropyridines in OLEDs."

Quality control of 3-Chloro-2-fluoropyridine involves rigorous HPLC and GC analysis to ensure purity >98%, a common requirement for pharmaceutical intermediates. Suppliers increasingly address FAQs like "How to store fluorinated pyridines?" (recommended: inert atmosphere, -20°C) or "What are alternatives to 3-Chloro-2-fluoropyridine?"—showcasing its irreplaceability in certain synthetic routes.

Environmental and regulatory aspects are also frequently searched. While 1480-64-4 isn’t classified as hazardous under major chemical inventories, its handling requires standard PPE due to potential irritant effects. This contrasts with misinformation sometimes found in forums, underscoring the need for authoritative sources.

Innovation continues around this compound: A 2024 preprint revealed its use in metal-organic frameworks (MOFs) for gas storage, tapping into the clean energy trend. Such developments position 3-Chloro-2-fluoropyridine as a bridge between traditional chemistry and cutting-edge technology.

For procurement specialists, understanding market dynamics is essential. Pricing fluctuations of fluoropyridine derivatives often correlate with lithium battery demand (unrelated but indicative of fluorine’s industrial value). Transparent suppliers now provide batch-specific COAs and stability data, responding to buyer priorities.

In summary, CAS No. 1480-64-4 exemplifies how targeted molecular modifications drive progress across industries. Its synergy with green chemistry principles (e.g., atom economy in fluorination) and adaptability to high-throughput screening methodologies ensure its enduring relevance.

• 1737-93-5(3,5-Dichloro-2,4,6-trifluoropyridine)
• 1480-65-5(5-Chloro-2-fluoropyridine)
• 2879-42-7(3-Chloro-2,5,6-trifluoropyridine)
• 209328-72-3(3-Chloro-2-fluoro-5-hydroxypyridine)
• 1031929-23-3(3-chloro-2-fluoro-5-methylpyridine)
• 851179-00-5(3-Chloro-2,5-difluoropyridine)
• 698-51-1(3,5-Dichloro-2,6-difluoropyridine)
• 34941-92-9(4-Chloro-2-fluoropyridine)
• 823-56-3(3,5-Dichloro-2-fluoropyridine)
• 52208-53-4(Pyridine, 3,4-dichloro-2,6-difluoro-)