Cas no 1478-61-1 (2,2-Bis-(4-hydroxyphenyl)hexafluoropropane)

2,2-Bis-(4-hydroxyphenyl)hexafluoropropane, also known as bisphenol AF, is a fluorinated aromatic compound with the molecular formula C??H??F?O?. This high-performance monomer is widely used in the synthesis of advanced polymers, particularly polyimides and epoxy resins, due to its exceptional thermal stability, chemical resistance, and low dielectric constant. The hexafluoroisopropylidene linkage imparts enhanced rigidity and hydrophobicity, making it suitable for high-temperature and corrosive environments. Its applications extend to coatings, adhesives, and electronic materials where durability and performance under extreme conditions are critical. The compound’s unique structure also contributes to improved mechanical properties and flame retardancy in polymer matrices.
2,2-Bis-(4-hydroxyphenyl)hexafluoropropane structure
1478-61-1 structure
Product Name:2,2-Bis-(4-hydroxyphenyl)hexafluoropropane
CAS No:1478-61-1
MF:C15H10F6O2
MW:336.229125499725
MDL:MFCD00000439
CID:41445
PubChem ID:87563906
Update Time:2025-10-30

2,2-Bis-(4-hydroxyphenyl)hexafluoropropane Chemical and Physical Properties

Names and Identifiers

    • Bisphenol AF
    • 4,4'-(Hexafluoroisopropylidene)diphenol
    • 4,4′-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bisphenol
    • BPAF
    • 2,2-Bis(4-hydroxyphenyl)hexafluoropropane
    • Hexafluoroisopropylidenebis(4-hydroxybenzene)
    • Hexafluorobisphenol A
    • Hexeafluorobisphenol A
    • 4,4′-(hexafluoroisopropylidene)diphenol
    • 4,4'-(perfluoropropane-2,2-diyl) diphenol
    • 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane
    • biphenolaf
    • BIS-AF
    • Bisphenol A Hexafluoride
    • BISPHENOL AF-M
    • DAIKIN YZ0001
    • hexafluorobisphenol
    • HexafluorophenolA
    • 4,4&priMe
    • BPAF(Bisphenol AF)
    • TIMTEC-BB SBB001375
    • 4,4'-(perfluoropropane-2,2-diyl)diphenol
    • Biphenol AF
    • Hexafluorodiphenylolpropane
    • Hexafluoroacetone bisphenol A
    • 2,2-Bis(4-hydroxyphenyl)perfluoropropane
    • 4,4'-(1,1,1,3,3,3-Hexafluoropropane-2,2-diyl)diphenol
    • 2,2-Bis-(p-hydroxyphenyl)-hexafluoropropane
    • hexafluoro-2,2-bis-(4-hydroxyphenyl)-propane
    • OH7IX8A37J
    • BDBM50544707
    • EINECS 216-036-7
    • Tox21_201467
    • HMS1538K16
    • Hexafluorobisphenol A, 98%
    • NCGC00164114-02
    • HSDB 8090
    • NS00011437
    • 4,4 inverted exclamation mark -(Hexafluoroisopropylidene)diphenol
    • NSC-152522
    • 4,4'-(Hexafluoroisopropylidene)diphenol, 97%
    • AS-14550
    • NSC 152522
    • 4,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]bisphenol
    • Tox21_303641
    • Q-200407
    • 4,4'-(perfluoroisopropylidene)diphenol
    • SY014750
    • 2,2-BIS(4-HYDROXYPHENYL)-1,1,1,3,3,3-HEXAFLUOROPROPANE
    • TimTec1_001644
    • DTXCID5017717
    • 2,2-Bis-(4-hydroxyphenyl)-1,1,1,3,3,3-hexafluoropropane
    • AC-15007
    • A808703
    • CAS-1478-61-1
    • 4,4'-(Hexafluoroisopropylidene)diphenol (Bisphenol AF)
    • 1478-61-1
    • B0945
    • NCGC00164114-04
    • NCGC00257463-01
    • BP_02 (BPAF)
    • SCHEMBL21027
    • Phenol, 4,4'-(2,2,2-trifluoro-1-(trifluoromethyl)ethylidene)bis-
    • BisphenolAF
    • FT-0609177
    • 1,1,1,3,3,3-hexafluoro-2,2-bis(4-hydroxyphenyl)propane
    • Phenol, 4,4'-(trifluoro-1-(trifluoromethyl)ethylidene)di-
    • 4,4'-(2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene)diphenol
    • 2,2-bis(4'-hydroxyphenyl)hexafluoropropane
    • 4-[2,2,2-trifluoro-1-(4-hydroxyphenyl)-1-(trifluoromethyl)ethyl]phenol
    • Phenol,4'-(bis(trifluoromethyl)methylene)di-
    • 0CZ
    • DTXSID7037717
    • NCGC00164114-01
    • UNII-OH7IX8A37J
    • Phenol, 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis-
    • C15H10F6O2
    • 4,4'-(Trifluoro-1-(trifluoromethyl)ethylidene)diphenol
    • MFCD00000439
    • 4,4'-(2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene)bisphenol
    • Q9658045
    • Phenol,4'-[trifluoro-1-(trifluoromethyl)ethylidene]di-
    • Phenol,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis-
    • CS-W014498
    • NSC152522
    • 4,4 inverted exclamation marka-(Hexafluoroisopropylidene)diphenol
    • CURATIVE 30
    • Phenol, 4,4'-(bis(trifluoromethyl)methylene)di-
    • CHEBI:72754
    • 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenol
    • Bisphenol??AF, analytical standard
    • NCGC00259018-01
    • Bisphenol AF 100 microg/mL in Methanol
    • NCGC00164114-03
    • phenol,4,4-(2,2,2-triflouro-1-(trifluromethyl)ethylidene]
    • BIDD:ER0048
    • CHEMBL1900054
    • AKOS005433772
    • Phenol, 4,4, (2,2,2, trifluoro-1-(trifluoromethyl)ethylidene) bis
    • Hexafluoroisopropylidenebis(4-hydroxybenzene); Hexafluorobisphenol A; Bisphenol AF
    • 4-(1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl)phenol
    • 2,2-bis(p-hydroxyphenyl)hexafluoropropane
    • 4,4'-hexafluorisopropylidene diphenol
    • STK396229
    • DB-005805
    • Phenol, 4,4'-
    • 1ST8728
    • FB54805
    • MSK8728
    • 216-036-7
    • MDL: MFCD00000439
    • Inchi: 1S/C15H10F6O2/c16-14(17,18)13(15(19,20)21,9-1-5-11(22)6-2-9)10-3-7-12(23)8-4-10/h1-8,22-23H
    • InChI Key: ZFVMWEVVKGLCIJ-UHFFFAOYSA-N
    • SMILES: FC(C(C(F)(F)F)(C1C=CC(=CC=1)O)C1C=CC(=CC=1)O)(F)F
    • BRN: 1891568

Computed Properties

  • Exact Mass: 336.05800
  • Monoisotopic Mass: 336.058
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 8
  • Heavy Atom Count: 23
  • Rotatable Bond Count: 2
  • Complexity: 352
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 3
  • XLogP3: 4.5
  • Topological Polar Surface Area: 40.5

Experimental Properties

  • Color/Form: With white powder.
  • Density: 1.3837 (estimate)
  • Melting Point: 160-163?°C (lit.)
  • Boiling Point: 400℃/760mmHg
  • Flash Point: >100℃
  • Refractive Index: 1.473
  • Water Partition Coefficient: Insoluble in water.
  • PSA: 40.46000
  • LogP: 4.50850
  • Solubility: Insoluble in water.

2,2-Bis-(4-hydroxyphenyl)hexafluoropropane Security Information

  • Symbol: GHS07
  • Prompt:warning
  • Signal Word:Warning
  • Hazard Statement: H315,H319,H335
  • Warning Statement: P261,P305+P351+P338
  • Hazardous Material transportation number:NONH for all modes of transport
  • WGK Germany:2
  • Hazard Category Code: 36/37/38
  • Safety Instruction: S26-S36-S37/39
  • RTECS:SN2780000
  • Hazardous Material Identification: Xi
  • Safety Term:S26;S37/39
  • Risk Phrases:R36/37/38
  • TSCA:Yes
  • Storage Condition:Store at room temperature

2,2-Bis-(4-hydroxyphenyl)hexafluoropropane Customs Data

  • HS CODE:2908199090
  • Customs Data:

    China Customs Code:

    2908199090

    Overview:

    HS:2908199090 Derivatives of other phenols and phenolic alcohols containing only halogen substituents and their salts VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

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2,2-Bis-(4-hydroxyphenyl)hexafluoropropane Suppliers

Suzhou Senfeida Chemical Co., Ltd
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(CAS:1478-61-1)Hexafluorobisphenol A
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(CAS:1478-61-1)Bisphenol AF
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(CAS:1478-61-1)2,2-Bis-(4-hydroxyphenyl)hexafluoropropane
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(CAS:1478-61-1)Hexafluorobisphenol A
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2,2-Bis-(4-hydroxyphenyl)hexafluoropropane Related Literature

Additional information on 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane

Professional Introduction to 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane (CAS No. 1478-61-1)

2,2-Bis-(4-hydroxyphenyl)hexafluoropropane, identified by the chemical identifier CAS No. 1478-61-1, is a fluorinated aromatic compound that has garnered significant attention in the field of chemical and pharmaceutical research due to its unique structural and functional properties. This compound belongs to a class of molecules that exhibit remarkable stability and reactivity, making it a valuable candidate for various applications in material science, drug development, and industrial processes.

The molecular structure of 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane consists of a hexafluoropropane backbone substituted with two 4-hydroxyphenyl groups. This arrangement imparts a high degree of hydrophobicity and thermal stability, which are critical attributes for its use in high-performance materials. The presence of hydroxyl groups on the aromatic rings also suggests potential for further functionalization, enabling the synthesis of more complex derivatives with tailored properties.

In recent years, 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane has been extensively studied for its applications in advanced polymer chemistry. Researchers have explored its role as a monomer or intermediate in the synthesis of high-performance resins and coatings. These materials exhibit exceptional resistance to heat, chemicals, and mechanical stress, making them ideal for use in aerospace, automotive, and electronics industries. The fluorinated nature of the compound contributes to its low surface energy and hydrophobicity, which are advantageous for creating durable and water-resistant surfaces.

Moreover, the hydroxyl groups in 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane provide opportunities for hydrogen bonding interactions, which can enhance the adhesion properties of polymers when used as additives or monomers. This has led to innovative approaches in developing adhesives and coatings that require strong bonding capabilities under extreme conditions. The compound's ability to form stable complexes with other molecules also makes it a promising candidate for use in drug delivery systems and bioactive materials.

Recent advancements in computational chemistry have further illuminated the potential of 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane in medicinal chemistry. Molecular modeling studies have revealed that this compound can interact with biological targets in unique ways due to its fluorinated aromatic core and hydroxyl functionalities. These interactions have been hypothesized to modulate enzyme activity and cellular processes, opening avenues for the development of novel therapeutic agents. Specifically, researchers are investigating its potential as an inhibitor or modulator in pathways related to inflammation and oxidative stress.

The synthesis of 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane involves multi-step organic reactions that require precise control over reaction conditions to ensure high yield and purity. The use of advanced catalytic systems has enabled more efficient production methods, reducing the environmental impact associated with traditional synthetic routes. Additionally, green chemistry principles have been applied to optimize solvent systems and minimize waste generation during the manufacturing process.

In industrial applications, 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane is utilized as a flame retardant additive in plastics and textiles. Its high thermal stability and ability to release non-flammable gases upon decomposition make it an effective fire suppressant. This property is particularly valuable in producing safer consumer products that meet stringent fire safety regulations without compromising material performance.

The compound's versatility also extends to its role as a crosslinking agent in polymer networks. By introducing 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane into polymer matrices, researchers can enhance mechanical strength and thermal resistance while maintaining flexibility. This has practical implications for developing lightweight yet robust materials used in construction, automotive components, and sports equipment.

From an environmental perspective, the sustainability of using CAS No. 1478-61-1 as a raw material or intermediate is a growing focus among chemists. Efforts are underway to develop biodegradable derivatives or alternative synthetic pathways that reduce reliance on fluorinated compounds while preserving their beneficial properties. Such innovations align with global efforts to promote sustainable chemistry practices across industries.

The future research directions for 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane are multifaceted. Ongoing studies aim to explore its potential in nanotechnology applications, where its unique molecular architecture could be leveraged for designing novel nanomaterials with enhanced functionality. Additionally, collaborations between academia and industry are paving the way for commercialization of new products based on this compound.

In conclusion,CAS No 1478-61-1, commonly referred to as 2, 22, bis(4-hydroxyphenyl)hexafluoropropane, represents a cornerstonein modern chemical research duetoits broad applicability across multiple disciplines. Itsstructural features, combinedwith ongoing advancements, ensure that this compound will remain at forefrontof innovation. As research progresses,new possibilities will continueemerge, solidifying its importanceIn future technologies.

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Jiangsu Xinsu New Materials Co., Ltd
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