Cas no 14777-27-6 (Methyl acetimidate hydrochloride)
Methyl acetimidate hydrochloride (CAS 14777-27-6) is a reactive imidate ester derivative widely used in organic synthesis and bioconjugation. This white to off-white crystalline powder serves as a versatile reagent for introducing acetimidate groups into target molecules, particularly in peptide modification and protein labeling. Its hydrochloride salt form enhances stability and solubility in aqueous and organic solvents. The compound reacts selectively with primary amines under mild conditions, making it valuable for crosslinking applications. With a molecular weight of 109.54 g/mol, it offers efficient modification of biomolecules while maintaining structural integrity. Proper handling under anhydrous conditions is recommended due to its moisture sensitivity.
14777-27-6 structure
Product Name:Methyl acetimidate hydrochloride
CAS No:14777-27-6
MF:C3H8ClNO
MW:109.554719924927
MDL:MFCD00012571
CID:138557
PubChem ID:10313100
Update Time:2025-05-27
Methyl acetimidate hydrochloride Chemical and Physical Properties
Names and Identifiers
-
- Methyl acetimidate hydrochloride
- Ethanimidic acid,methyl ester, hydrochloride (1:1)
- FGIN-1-43
- ACETIMIDIC ACID METHYL ESTER,HYDROCHLORIDE
- methyl ethanimidate,hydrochloride
- METHYL ACETIMIDATE HCL
- AcetimidicacidmethylesterHCl
- METHYL ACETIMIDATE HYDROCHLORIDE, TECH.
- ethanimidicacid,methylester,hydrochloride
- Methyl acetiMidate hydrochloride , Technical
- Methyl acetimidate hydrochloride technical grade
- acetimidicacid,methylester,hydrochloride
- Methyl acetimidate hydrochlorideTechnical, ≥ 99% (Assay by Titration)
- Methyl acetimidate hydrochloride, technical grade
- BP-10648
- FT-0621766
- Methyl acetimidate, HCl
- 05I74I2UQ2
- Ethanimidic acid, methyl ester, hydrochloride (1:1)
- J-008410
- EN300-102475
- AKOS015902715
- 14777-27-6
- MFCD00012571
- WHYJXXISOUGFLJ-UHFFFAOYSA-N
- Q27236117
- DTXSID80884769
- Ethanimidic acid, methyl ester, hydrochloride
- BS-21434
- methyl ethanecarboximidate hydrochloride
- NS00052224
- SCHEMBL2266274
- Methylacetimidate hydrochloride
- methyl ethanimidate;hydrochloride
- O-methyl acetimidate hydrochloride
- Acetimidic Acid Methyl Ester Hydrochloride
- UNII-05I74I2UQ2
- DB-042902
- Methyl ethanimidate, hydrochloride
- EINECS 238-843-3
- DTXCID301024193
-
- MDL： MFCD00012571
- Inchi： 1S/C3H7NO.ClH/c1-3(4)5-2;/h4H,1-2H3;1H
- InChI Key： WHYJXXISOUGFLJ-UHFFFAOYSA-N
- SMILES： Cl.O(C)C(C)=N
Computed Properties
- Exact Mass: 109.02900
- Monoisotopic Mass: 73.052764
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 6
- Rotatable Bond Count: 1
- Complexity: 42.2
- Covalently-Bonded Unit Count: 2
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: 2
- XLogP3: nothing
- Topological Polar Surface Area: 33.1
Experimental Properties
- Melting Point: 105?°C (dec.) (lit.)
- Boiling Point: 24.4°Cat760mmHg
- Flash Point: 5.7°C
- Refractive Index: 1.389
- PSA: 33.08000
- LogP: 1.53170
Methyl acetimidate hydrochloride Security Information
-
Symbol:
- Signal Word：Warning
- Hazard Statement： H315-H319-H335
- Warning Statement： P261-P305+P351+P338
- Hazardous Material transportation number：UN 2811 6.1/PG 3
- WGK Germany：3
- Hazard Category Code： 36/37/38
- Safety Instruction： S26; S36
- FLUKA BRAND F CODES：10-21
- RTECS：AK2950000
-
Hazardous Material Identification：
- Storage Condition：2-8°C
- Risk Phrases：R36/37/38
Methyl acetimidate hydrochloride Customs Data
- HS CODE：2925290090
- Customs Data：
China Customs Code:
2925290090Overview:
2925290090 Other imines and their derivatives,And their salt.Regulatory conditions:nothing.VAT:17.0%.Tax refund rate:9.0%.MFN tariff:6.5%.general tariff:30.0%
Declaration elements:
Product Name, component content, use to
Summary:
2925290090 other imines and their derivatives; salts thereof.Supervision conditions:None.VAT:17.0%.Tax rebate rate:9.0%.MFN tariff:6.5%.General tariff:30.0%
Methyl acetimidate hydrochloride Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | 254940-25G |
Methyl acetimidate hydrochloride |
14777-27-6 | 25g |
￥5280.22 | 2023-12-09 | ||
| XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd. | 254940-100G |
Methyl acetimidate hydrochloride |
14777-27-6 | technical grade | 100G |
￥18301.4 | 2022-02-24 | |
| TRC | M275025-500mg |
Methyl Acetimidate Hydrochloride |
14777-27-6 | 500mg |
$64.00 | 2023-05-18 | ||
| TRC | M275025-1g |
Methyl Acetimidate Hydrochloride |
14777-27-6 | 1g |
$ 60.00 | 2022-06-04 | ||
| TRC | M275025-5g |
Methyl Acetimidate Hydrochloride |
14777-27-6 | 5g |
$138.00 | 2023-05-18 | ||
| TRC | M275025-10g |
Methyl Acetimidate Hydrochloride |
14777-27-6 | 10g |
$201.00 | 2023-05-18 | ||
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | SA03431-100g |
Methyl acetimidate hydrochloride |
14777-27-6 | - | 100g |
￥27558.0 | 2024-07-18 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | SA03431-25g |
Methyl acetimidate hydrochloride |
14777-27-6 | - | 25g |
￥7008.0 | 2024-07-18 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M167386-25g |
Methyl acetimidate hydrochloride |
14777-27-6 | 97% | 25g |
￥2235.90 | 2023-09-02 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | M167386-100g |
Methyl acetimidate hydrochloride |
14777-27-6 | 97% | 100g |
￥5355.90 | 2023-09-02 |
Methyl acetimidate hydrochloride Related Literature
-
1. Spectroscopic studies. Part VIII. Infrared spectra and structure of methyl acetimidate and methyl acetimidate hydrochlorideW. H. Prichard,W. J. Orville-Thomas J. Chem. Soc. A 1967 1102
-
2. Intramolecular amidoseleniation of N-alkenyl imidates to N-heterocyclesKeiji Terao,Akio Toshimitsu,Sakae Uemura J. Chem. Soc. Perkin Trans. 1 1986 1837
-
3. Index of subjects, 1967
-
4. Photo-regulation of hydrolysis activity of semisynthetic mutant phospholipases A2 replaced by non-natural aromatic amino acidsTakehiko Ueda,Koichi Murayama,Tadayuki Yamamoto,Shunsaku Kimura,Yukio Imanishi J. Chem. Soc. Perkin Trans. 1 1994 225
-
5. Semisynthesis of mutant cytochromes c replaced by non-natural aromatic amino acid at Phe82 and photoregulation of reduction reaction with 2-mercaptoethanolTakehiko Ueda,Shunsaku Kimura,Yukio Imanishi J. Chem. Soc. Perkin Trans. 1 1994 219
14777-27-6 (Methyl acetimidate hydrochloride) Related Products
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- 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
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