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• 2. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 3. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
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• 4. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
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• 5. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl alcohols

(3-Ethoxy-4-methoxyphenyl)methanol (CAS No. 147730-26-5): A Versatile Organic Compound with Emerging Applications in Medicinal Chemistry and Materials Science

(3-Ethoxy-4-methoxyphenyl)methanol (CAS No. 147730-26-5) is a structurally unique aromatic alcohol characterized by its substituted phenyl ring and hydroxymethyl functionality. This compound, with the molecular formula C₁₂H₁₆O₃, exhibits a distinctive combination of electronic and steric properties that have sparked significant interest in both academic and industrial research settings. Recent advancements in medicinal chemistry have highlighted its potential as a building block for the development of novel bioactive molecules, particularly in the design of small-molecule therapeutics targeting kinase and GPCR pathways. The compound's 3-ethoxy-4-methoxyphenyl moiety provides a flexible scaffold for functional group modifications, making it a valuable precursor in combinatorial chemistry approaches.

The chemical structure of (3-Ethoxy-4-methoxyphenyl)methanol features a benzene ring substituted with an ethoxy group at the 3-position and a methoxy group at the 4-position, with a hydroxymethyl group attached to the para-carbon of the aromatic ring. This arrangement creates a conjugated system that influences the molecule's reactivity and solubility characteristics. Recent computational studies published in Journal of Medicinal Chemistry (2023) have demonstrated that the compound's molecular geometry allows for optimal hydrogen bonding interactions with hydrophobic pockets in target proteins, a property that has been exploited in the design of selective kinase inhibitors. These findings align with the growing emphasis on structure-based drug design in the pharmaceutical industry.

In the realm of organic synthesis, (3-Ethoxy-4-methoxyphenyl)methanol has emerged as a key intermediate in the preparation of fluorinated analogs with enhanced metabolic stability. A 2023 study in Organic Letters reported the successful use of this compound in the synthesis of a series of 2-aryl-4-(3-ethoxy-4-methoxyphenyl)-1,3-oxazol-5(4H)-one derivatives, which exhibited improved bioavailability profiles compared to their unsubstituted counterparts. The 3-ethoxy-4-methoxyphenyl substituent was found to significantly modulate the electronic distribution in the oxazole ring, enabling fine-tuning of pharmacokinetic properties through strategic functional group placement.

Recent advances in materials science have also uncovered novel applications for (3-Ethoxy-4-methoxyphenyl)methanol in the development of optoelectronic materials. Researchers at the Max Planck Institute for Polymer Research (2024) have demonstrated that the compound can serve as a crosslinking agent in the synthesis of conjugated polymers with tunable bandgap energies. The presence of both ether and hydroxyl functional groups in the molecule allows for precise control over polymer chain rigidity and intermolecular interactions, which are critical parameters in determining the performance of organic photovoltaic devices. This application aligns with the global push toward sustainable energy solutions using organic semiconductor materials.

In the context of drug discovery, (3-Ethoxy-4-methoxyphenyl)methanol has been evaluated as a potential lead compound for the treatment of neurodegenerative disorders. A 2024 preclinical study published in ACS Chemical Neuroscience reported that derivatives of this compound exhibited moderate neuroprotective effects in vitro models of Alzheimer's disease. The compound's ability to modulate oxidative stress pathways through its antioxidant properties was identified as a key mechanism of action. These findings have prompted further investigations into its potential as a scaffold for the development of multifunctional therapeutics targeting both amyloid-β aggregation and neuroinflammation.

The synthetic accessibility of (3-Ethoxy-4-methoxyphenyl)methanol has been a focus of recent methodological advancements. A 2023 report in Advanced Synthesis & Catalysis described an efficient one-pot protocol for its preparation via palladium-catalyzed cross-coupling reactions, achieving yields exceeding 90% under mild reaction conditions. This method, which utilizes readily available starting materials and avoids the use of toxic reagents, has been adopted by several pharmaceutical companies for the scale-up of intermediates in drug development pipelines. The compound's compatibility with a wide range of functional group transformations further enhances its utility in medicinal chemistry research.

Environmental and safety considerations have also been addressed in recent studies on (3-Ethoxy-4-methoxyphenyl)methanol. A 2024 lifecycle assessment published in Green Chemistry concluded that the compound has a relatively low environmental impact compared to conventional aromatic solvents used in organic synthesis. Its biodegradability profile and low aquatic toxicity make it a promising candidate for green chemistry applications. These properties are particularly relevant in the context of the European Union's REACH regulations, which emphasize the use of safer chemical alternatives in industrial processes.

Looking ahead, the compound's versatility is expected to drive further innovation across multiple scientific disciplines. Ongoing research at the intersection of medicinal chemistry and materials science is exploring its potential as a dual-function molecule, capable of serving as both a pharmacophore and a structural component in advanced materials. As the scientific community continues to unravel the full potential of (3-Ethoxy-4-methoxyphenyl)methanol (CAS No. 147730-26-5), it is poised to play a pivotal role in the next generation of therapeutic and functional materials.

• 83459-29-4(3,4-Diethoxybenzyl alcohol)
• 80851-85-0(Phenol, 2-methoxy-4-[(2-methoxyphenoxy)methyl]-)
• 33693-48-0(4-(Benzyloxy)-3-methoxy-benzyl Alcohol)
• 61813-58-9(4-Ethoxy-3-methoxybenzyl alcohol)
• 5595-79-9(Phenol,2-ethoxy-4-(methoxymethyl)-)
• 31574-14-8(Benzene,1,2-dimethoxy-4-[(4-methoxyphenoxy)methyl]-)
• 4912-58-7(3-Ethoxy-4-hydroxybenzyl Alcohol)
• 90139-54-1(Phenol, 2-methoxy-4-[(2-methoxy-4-methylphenoxy)methyl]-)
• 39727-75-8(3,4,5-Triethoxybenzyl Alcohol)
• 10548-82-0(Benzene, 1,2-dimethoxy-4-[(2-methoxyphenoxy)methyl]-)