Cas no 14763-60-1 (4-(Methylsulfonyl)phenol)

4-(Methylsulfonyl)phenol is a sulfone-substituted phenolic compound characterized by the presence of a methylsulfonyl group at the para position of the phenol ring. This structural feature imparts enhanced chemical stability and reactivity, making it a valuable intermediate in organic synthesis and pharmaceutical applications. The electron-withdrawing nature of the sulfonyl group influences the phenolic hydroxyl's acidity, facilitating its use in coupling reactions and as a building block for more complex molecules. Its high purity and well-defined properties ensure consistent performance in research and industrial processes. The compound is particularly useful in the development of agrochemicals, dyes, and specialty polymers.

4-(Methylsulfonyl)phenol structure

Product Name:4-(Methylsulfonyl)phenol

CAS No:14763-60-1

MF:C₇H₈O₃S

MW:172.201621055603

MDL:MFCD00047806

CID:49922

PubChem ID:123350

Update Time:2025-06-25

4-(Methylsulfonyl)phenol Chemical and Physical Properties

Names and Identifiers

- 4-(Methylsulfonyl)phenol
- 4-Hydroxyphenyl Methyl Sulfone
- 4-(Methylsulphonyl)phenol
- 4-Methylsulfonylphenol
- 4-Methylsulphonylphenol
- 4-Mesylphenol
- 4-Methylsulfonylphen
- p-Methylsulphonylphenol
- 4-(methylsulfonyl)-pheno
- 4-METHANESULFONYL-PHENOL
- p-(Methylsulfonyl)phenol
- p-(methylsulfonyl)-pheno
- 4-METHANESULPHONYLPHENOL
- 4-methanesulfonylphenol
- phenol, 4-(methylsulfonyl)-
- Phenol, p-(methylsulfonyl)-
- p-Hydroxyphenyl methyl sulfone
- F7BIF7ZQJ9
- PubChem10832
- 4-methylsulfonyl phenol
- 4-methylsulfonyl-phenol
- p-methy
- H1367
- AM20061098
- p-methyl sulfonyl phenol
- EN300-23056
- Q27277760
- DTXSID80163763
- PS-3171
- InChI=1/C7H8O3S/c1-11(9,10)7-4-2-6(8)3-5-7/h2-5,8H,1H
- KECCFSZFXLAGJS-UHFFFAOYSA-N
- AE-848/33833060
- AC-1241
- Z147646800
- CHEMBL66861
- P-(METHANESULFONYL)PHENOL
- ELAIDICANHYDRIDE
- 4-(Methylsulfonyl)phenol, analytical standard
- FT-0637135
- SCHEMBL1535
- 14763-60-1
- UNII-F7BIF7ZQJ9
- AKOS005171779
- O11094
- BP-10814
- BDBM50266956
- AB02067
- CS-W004825
- 4-(methanesulfonyl)phenol
- J-515826
- 4-(methylsulfonyl) phenol
- MFCD00047806
- 4-(Methylsulfonyl)-phenol
- BENZENE,1-HYDROXY,4-METHYLSULFONYL (PHENOL,4-METHYLSULFONYL)
- SY007820
- 4-Methanesulfonyl-phenol;4-(Methylsulfonyl)phenol
- J-008378
- STK505595
- DB-008353
- DTXCID6086254
- phenol, 4-mesyl-
- MDL： MFCD00047806
- Inchi： 1S/C7H8O3S/c1-11(9,10)7-4-2-6(8)3-5-7/h2-5,8H,1H3
- InChI Key： KECCFSZFXLAGJS-UHFFFAOYSA-N
- SMILES： S(C)(C1C=CC(=CC=1)O)(=O)=O

Computed Properties

Exact Mass: 172.01900
Monoisotopic Mass: 172.01941529g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Heavy Atom Count: 11
Rotatable Bond Count: 1
Complexity: 206
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: 2
XLogP3: 0.1
Topological Polar Surface Area: 62.8

Experimental Properties

Color/Form: Yellowish brown powder
Density: 1.3692 (rough estimate)
Melting Point: 93.0 to 97.0 deg-C
Boiling Point: 272.52°C (rough estimate)
Refractive Index: 1.5151 (estimate)
Water Partition Coefficient: slight
PSA: 62.75000
LogP: 1.87650
Solubility: Slightly soluble in water

4-(Methylsulfonyl)phenol Security Information

Symbol:
Prompt：warning
Signal Word：Warning
Hazard Statement： H303-H319
Warning Statement： P264-P280-P305+P351+P338+P337+P313-P312
Hazardous Material transportation number：NONH for all modes of transport
WGK Germany：3
Hazard Category Code： 36
Safety Instruction： S24/25
RTECS：SM1530000
Hazardous Material Identification：
Storage Condition：Inert atmosphere,Room Temperature
Safety Term：S24/25

4-(Methylsulfonyl)phenol Customs Data

HS CODE：2908999090
Customs Data：

China Customs Code:
2908999090

Overview:

2908999090 Halogenated derivatives of other phenols and phenolic alcohols(Including its sulfonation\Nitrosative or nitrosative derivatives). VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%

Declaration elements:

Product Name, component content, use to

Summary:

2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols.Supervision conditions:None.VAT:17.0%.Tax rebate rate:9.0%.MFN tariff:5.5%.General tariff:30.0%

4-(Methylsulfonyl)phenol Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
TI XI AI ( SHANG HAI ) HUA CHENG GONG YE FA ZHAN Co., Ltd.	H1367-25G	4-Hydroxyphenyl Methyl Sulfone	14763-60-1	>98.0%(GC)	25g	￥1080.00	2024-04-17
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	H157189-100g	4-(Methylsulfonyl)phenol	14763-60-1	>98.0%	100g	￥663.90	2023-09-02
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	H157189-10g	4-(Methylsulfonyl)phenol	14763-60-1	>98.0%	10g	￥84.90	2023-09-02
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	H157189-1g	4-(Methylsulfonyl)phenol	14763-60-1	>98.0%	1g	￥41.90	2023-09-02
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	H157189-25G	4-(Methylsulfonyl)phenol	14763-60-1	>98.0%	25g	￥183.90	2023-09-02
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	H157189-500g	4-(Methylsulfonyl)phenol	14763-60-1	>98.0%	500g	￥3077.90	2023-09-02
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	H157189-5G	4-(Methylsulfonyl)phenol	14763-60-1	>98.0%	5g	￥52.90	2023-09-02
Chemenu	CM116875-500g	4-(Methylsulfonyl)phenol	14763-60-1	95+%	500g	$617	2021-06-17
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.	H835316-25g	4-Hydroxyphenyl Methyl Sulfone	14763-60-1	98%	25g	351.00	2021-05-17
Fluorochem	023361-1g	4-(Methylsulfonyl)phenol	14763-60-1	97%	1g	￡10.00	2022-02-28

4-(Methylsulfonyl)phenol Production Method

4-(Methylsulfonyl)phenol Suppliers

Suzhou Senfeida Chemical Co., Ltd

Gold Member

Audited Supplier

(CAS:14763-60-1)4-(Methylsulfonyl)phenol

Order Number:sfd228

Stock Status:in Stock

Quantity:200kg

Purity:99.9%

Pricing Information Last Updated:Friday, 19 July 2024 14:32

Price ($):discuss personally

Email:[email protected]

Product Official Link

4-(Methylsulfonyl)phenol Related Literature

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Irene Piergentili,Pepijn R. Bouwmans,Luuk Reinalda,Reece W. Lewis,Benjamin Klemm,Huanhuan Liu,Robin M. de Kruijff,Antonia G. Denkova,Rienk Eelkema Polym. Chem. 2022 13 2383

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Additional information on 4-(Methylsulfonyl)phenol

Comprehensive Guide to 4-(Methylsulfonyl)phenol (CAS No. 14763-60-1): Properties, Applications, and Industry Insights

4-(Methylsulfonyl)phenol (CAS No. 14763-60-1), also known as Methylsulfonylphenol or p-(Methylsulfonyl)phenol, is a versatile organic compound widely used in pharmaceuticals, agrochemicals, and specialty chemical synthesis. Its unique molecular structure, featuring a sulfonyl group and a hydroxyl group on a benzene ring, grants it exceptional reactivity and solubility properties. This article explores its chemical characteristics, industrial applications, and answers trending questions like "Is 4-(Methylsulfonyl)phenol biodegradable?" or "How does Methylsulfonylphenol compare to similar sulfone derivatives?"

The compound’s CAS registry number 14763-60-1 ensures precise identification in global chemical databases. With a molecular formula of C₇H₈O₃S and a molar mass of 172.20 g/mol, it typically appears as a white to off-white crystalline powder. Its melting point ranges between 120–125°C, and it exhibits moderate solubility in polar solvents like ethanol and acetone. Researchers frequently highlight its role as a key intermediate in synthesizing anti-inflammatory drugs and crop protection agents, aligning with the growing demand for sustainable agriculture solutions.

In pharmaceutical contexts, 4-(Methylsulfonyl)phenol serves as a precursor for COX-2 inhibitors, addressing searches such as "sulfone-based drug development 2024." Its electron-withdrawing sulfonyl group enhances electrophilic substitution reactions, making it valuable for designing novel APIs (Active Pharmaceutical Ingredients). Recent studies also investigate its potential in green chemistry applications, responding to queries like "eco-friendly sulfone compounds."

From an industrial perspective, this compound’s thermal stability and compatibility with polymer matrices have spurred interest in high-performance materials. For instance, it’s explored in flame-retardant additives—a hot topic given stricter safety regulations. Analytical methods like HPLC and GC-MS are commonly employed for purity verification, as users often search for "CAS 14763-60-1 testing protocols."

Environmental and safety profiles are critical concerns. While 4-(Methylsulfonyl)phenol isn’t classified as hazardous under GHS, proper handling guidelines recommend PPE to avoid irritation. Biodegradability studies show partial breakdown in aerobic conditions, a frequent search topic among environmental chemists. Regulatory compliance (e.g., REACH, FDA) is thoroughly documented, addressing queries like "Is Methylsulfonylphenol FDA-approved?"

Innovation trends spotlight its utility in photocatalysis and battery electrolytes, aligning with renewable energy demands. Startups are patenting methods to reduce synthetic byproducts, answering searches for "cost-effective 4-(Methylsulfonyl)phenol production." The compound’s derivatives, such as its acetate ester, further expand applications in fragrances and coatings.

To summarize, 4-(Methylsulfonyl)phenol (CAS 14763-60-1) bridges multiple industries with its adaptable chemistry. Whether you’re researching "sulfone cross-coupling reactions" or "high-purity phenolic sulfones," this compound offers a compelling case study in modern chemical innovation.

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