• 1. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 2. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 3. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683
• 4. Evolution and characterization of a benzylguanine-binding RNA aptamer?
  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
• 5. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Primary alcohols
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alcohols and polyols Primary alcohols

Rac-(1R,2R)-2-Propylcyclopropylmethanol, trans (CAS No. 147228-48-6): An Overview of Its Structure, Properties, and Applications

Rac-(1R,2R)-2-Propylcyclopropylmethanol, trans (CAS No. 147228-48-6) is a chiral compound that has garnered significant attention in the fields of organic chemistry and pharmaceutical research due to its unique structural properties and potential applications. This compound is a member of the cyclopropanol family and is characterized by its trans configuration, which plays a crucial role in its chemical behavior and biological activity.

The molecular formula of rac-(1R,2R)-2-Propylcyclopropylmethanol, trans is C₈H₁₆O, with a molecular weight of approximately 128.20 g/mol. The compound consists of a cyclopropane ring substituted with a propyl group and a hydroxymethyl group. The trans configuration refers to the spatial arrangement of the substituents on the cyclopropane ring, which can significantly influence the compound's reactivity and selectivity in various chemical reactions.

In terms of physical properties, rac-(1R,2R)-2-Propylcyclopropylmethanol, trans is a colorless liquid at room temperature. It has a boiling point of around 150°C and is soluble in common organic solvents such as ethanol, acetone, and dichloromethane. These properties make it suitable for use in various synthetic processes and analytical methods.

The synthesis of rac-(1R,2R)-2-Propylcyclopropylmethanol, trans can be achieved through several routes, including the ring-opening reaction of epoxides or the addition of organometallic reagents to aldehydes or ketones. One common method involves the reaction of propargylic alcohols with organocopper reagents followed by reduction to form the desired cyclopropanol structure. Recent advancements in asymmetric synthesis have also led to more efficient and selective methods for producing enantiomerically pure forms of this compound.

The chiral nature of rac-(1R,2R)-2-Propylcyclopropylmethanol, trans makes it an important intermediate in the synthesis of chiral drugs and other bioactive molecules. Chirality is a critical factor in pharmaceutical research because enantiomers can exhibit different biological activities and pharmacological profiles. For example, one enantiomer may be more potent or have fewer side effects compared to its mirror image. Therefore, the ability to synthesize and isolate specific enantiomers is essential for developing effective therapeutic agents.

In recent studies, rac-(1R,2R)-2-Propylcyclopropylmethanol, trans has been investigated for its potential as a building block in the synthesis of novel antiviral agents. Researchers have explored its use in the development of inhibitors for viral proteases and other key enzymes involved in viral replication. Preliminary results have shown promising activity against several viruses, including influenza and coronaviruses. These findings highlight the potential of this compound as a valuable starting material for drug discovery efforts.

Beyond its applications in pharmaceutical research, rac-(1R,2R)-2-Propylcyclopropylmethanol, trans has also found use in materials science and catalysis. Its unique structural features make it an attractive ligand for designing transition metal catalysts that can facilitate stereoselective transformations. These catalysts have been employed in various synthetic processes to produce high-value chemicals with high enantioselectivity.

In conclusion, rac-(1R,2R)-2-Propylcyclopropylmethanol, trans (CAS No. 147228-48-6) is a versatile compound with significant potential in multiple scientific disciplines. Its unique structure and chiral properties make it an important intermediate in organic synthesis and a valuable tool for developing new drugs and materials. Ongoing research continues to uncover new applications for this compound, further solidifying its importance in the fields of chemistry and pharmaceutical science.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)