• 1. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
• 2. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 3. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 4. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 5. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168

2-Bromo-4-Methylphenyl Chloroformate: A Comprehensive Overview

The compound with CAS No. 1471282-52-6, commonly referred to as 2-bromo-4-methylphenyl chloroformate, is a highly specialized organic compound that has garnered significant attention in the fields of organic chemistry, materials science, and pharmaceutical research. This compound is a derivative of phenyl chloroformate, where a bromine atom is substituted at the 2-position and a methyl group at the 4-position of the benzene ring. Its unique structure endows it with distinctive chemical properties, making it a valuable building block in various synthetic processes.

Chloroformates are reactive intermediates widely used in organic synthesis due to their ability to form esters, mixed carbonates, and other derivatives. The presence of a bromine atom in 2-bromo-4-methylphenyl chloroformate introduces additional reactivity and selectivity in reactions, particularly in nucleophilic acyl substitution reactions. Recent studies have highlighted its potential as a key intermediate in the synthesis of advanced materials, such as high-performance polymers and biodegradable plastics.

One of the most notable applications of 2-bromo-4-methylphenyl chloroformate is in the field of drug discovery. Researchers have explored its role as a precursor in the synthesis of bioactive compounds, including antiviral and anticancer agents. For instance, a study published in *Journal of Medicinal Chemistry* demonstrated that derivatives of this compound exhibit potent inhibitory activity against certain enzymes involved in cancer cell proliferation.

The synthesis of 2-bromo-4-methylphenyl chloroformate typically involves multi-step processes that require precise control over reaction conditions to ensure high yields and purity. A common approach involves the bromination of 4-methylphenyl chloroformate followed by purification techniques such as column chromatography or recrystallization. Recent advancements in catalytic methods have enabled more efficient and environmentally friendly syntheses, reducing production costs and minimizing waste.

In terms of chemical properties, 2-bromo-4-methylphenyl chloroformate is known for its stability under mild conditions, although it reacts vigorously under basic or nucleophilic conditions. Its solubility characteristics make it suitable for use in both polar and non-polar solvents, depending on the specific application. The compound's reactivity can be further modulated by varying substituents on the benzene ring or by incorporating additional functional groups.

From an environmental standpoint, there is growing interest in understanding the degradation pathways of 2-bromo-4-methylphenyl chloroformate to assess its potential impact on ecosystems. Studies conducted by environmental chemists have shown that under aerobic conditions, this compound undergoes hydrolysis to form less harmful byproducts. However, further research is needed to evaluate its long-term effects on aquatic life and soil microorganisms.

Looking ahead, the demand for 2-bromo-4-methylphenyl chloroformate is expected to rise as industries continue to explore sustainable synthetic routes and novel applications. Its versatility as a chemical intermediate positions it as a critical component in the development of next-generation materials and therapeutic agents.

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• 54060-68-3(2,4,6-tribromophenyl chloroformate)
• 7693-44-9(4-Bromophenyl Chloroformate)
• 2693-44-9(4-BroMophenyl chloroforMate)
• 1509029-49-5(2-bromo-4-chlorophenyl chloroformate)
• 1523039-06-6(4-bromo-2-methylphenyl chloroformate)
• 89629-87-8(2-bromophenyl chloroformate)