• 1. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207
• 2. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 3. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 4. Excellent humidity sensor based on ultrathin HKUST-1 nanosheets?
  Qiaoe Wang,Meiling Lian,Xiaowen Zhu,Xu Chen RSC Adv., 2021,11, 192-197
• 5. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248

5-Amino-1-(4-Methylphenyl)-1h-Pyrazole-4-Carboxylic Acid (CAS No. 14678-93-4): An Overview

5-Amino-1-(4-Methylphenyl)-1H-pyrazole-4-carboxylic acid (CAS No. 14678-93-4) is a versatile compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, characterized by its unique structural features, has shown promising potential in various applications, particularly in the development of novel therapeutic agents.

The chemical structure of 5-Amino-1-(4-Methylphenyl)-1H-pyrazole-4-carboxylic acid consists of a pyrazole ring substituted with an amino group at the 5-position and a 4-methylphenyl group at the 1-position. The carboxylic acid moiety at the 4-position further enhances its reactivity and functional versatility. This combination of functional groups imparts the compound with a range of desirable properties, including high solubility, stability, and biological activity.

Recent studies have highlighted the significance of 5-Amino-1-(4-Methylphenyl)-1H-pyrazole-4-carboxylic acid in the development of drugs targeting various diseases. One notable area of research is its potential as an anti-inflammatory agent. In vitro and in vivo studies have demonstrated that this compound exhibits potent anti-inflammatory effects by inhibiting key enzymes involved in the inflammatory response, such as cyclooxygenase (COX) and lipoxygenase (LOX). These findings suggest that 5-Amino-1-(4-Methylphenyl)-1H-pyrazole-4-carboxylic acid could be a valuable lead compound for the development of new anti-inflammatory drugs with reduced side effects compared to existing treatments.

Beyond its anti-inflammatory properties, 5-Amino-1-(4-Methylphenyl)-1H-pyrazole-4-carboxylic acid has also shown promise in the treatment of neurodegenerative diseases. Research has indicated that this compound can cross the blood-brain barrier and exert neuroprotective effects by modulating oxidative stress and reducing neuroinflammation. These properties make it a potential candidate for the treatment of conditions such as Alzheimer's disease and Parkinson's disease, where oxidative stress and inflammation play critical roles in disease progression.

In addition to its therapeutic applications, 5-Amino-1-(4-Methylphenyl)-1H-pyrazole-4-carboxylic acid has been explored for its use as a building block in organic synthesis. Its reactive carboxylic acid group allows for facile derivatization, enabling chemists to synthesize a wide range of derivatives with tailored properties. This versatility has led to its use in the development of novel materials, such as polymers and coatings, which benefit from its unique chemical characteristics.

The synthesis of 5-Amino-1-(4-Methylphenyl)-1H-pyrazole-4-carboxylic acid can be achieved through various routes, including multistep processes involving condensation reactions and functional group transformations. Recent advancements in synthetic methodologies have focused on improving the efficiency and yield of these processes, making it more accessible for large-scale production. One such method involves the use of microwave-assisted synthesis, which has been shown to significantly reduce reaction times while maintaining high product purity.

The safety profile of 5-Amino-1-(4-Methylphenyl)-1H-pyrazole-4-carboxylic acid is another important consideration for its practical applications. Extensive toxicological studies have demonstrated that this compound exhibits low toxicity at therapeutic concentrations, making it suitable for use in pharmaceutical formulations. However, as with any chemical compound, proper handling and storage protocols should be followed to ensure safety and maintain product integrity.

In conclusion, 5-Amino-1-(4-Methylphenyl)-1H-pyrazole-4-carboxylic acid (CAS No. 14678-93-4) is a multifaceted compound with significant potential in various fields of research and application. Its unique chemical structure and versatile properties make it an attractive candidate for the development of novel therapeutic agents and advanced materials. Ongoing research continues to uncover new avenues for its use, further solidifying its importance in the scientific community.

• 15001-11-3(Ethyl 5-amino-1-(4-methylphenyl)-1H-pyrazole-4-carboxylate)
• 187949-90-2(5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylic acid)
• 112960-04-0(ethyl 5-amino-1-(3,5-dimethylphenyl)-1H-pyrazole-4-carboxylate)
• 1034142-09-0(5-AMINO-1-(3-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID)
• 51649-80-0(5-Amino-1-phenyl-1H-pyrazole-4-carboxylic acid)
• 29097-01-6(1H-Pyrazole-4-carboxylic acid, 5-amino-1-phenyl-, methyl ester)
• 926203-48-7(4-5-amino-4-(ethoxycarbonyl)-1H-pyrazol-1-ylbenzoic acid)
• 438243-87-9(5-Amino-1-(4-bromophenyl)-1H-pyrazole-4-carboxylic acid)
• 14678-91-2(5-Amino-1-(2-methylphenyl)-1H-pyrazole-4-carboxylic acid)
• 187949-91-3