Cas no 146275-18-5 (trans-3'-Hydroxy Cotinine N-b-D-Glucuronide)
trans-3'-Hydroxy Cotinine N-b-D-Glucuronide Chemical and Physical Properties
Names and Identifiers
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- Pyridinium, 1-b-D-glucopyranuronosyl-3-[(2S,4R)-4-hydroxy-1-methyl-5-oxo-2-pyrrolidinyl]-,inner salt
- 1-Methyl-2-oxo-5-(3-pyridinyl)-3-pyrrolidinyl hexopyranosiduronic acid
- Pyridinium, 1-b-D-glucopyranuronosyl-3-[(2S,4R)-4-hydroxy-1-methyl-5-oxo-2-pyrrolidinyl]-,inne...
- trans-3?-Hydroxy Cotinine N-β-D-Glucuronide
- trans-3'-Hydroxy Cotinine N-β-D-Glucuronide
- TRANS-3'-HYDROXYCOTININE-N-B-D-GLUCURONIDE
- 1-methyl-2-oxo-5-(pyridin-3-yl)pyrrolidin-3-yl hexopyranosiduronic acid
- trans-3-Hydroxycotinine glucuronide
- trans-3'-Hydroxycotinine-N-glucuronide
- trans-3'-Hydroxy Cotinine-d3 N-β-D-Glucuronide
- 1-β-D-Glucopyranuronosyl-3-[(2S,4R)-4-hydroxy-1-Methyl-5-oxo-2-pyrrolidinyl]pyridiniuM
- 1-β-D-Glucopyranuronosyl-3-[(2S,4R)-4-hydroxy-1-Methyl-5-oxo-2-pyrrolidinyl]pyridiniuM Inner Salt
- trans-3-Hydroxy Cotinine-β-D-Glucuronide
- (2S,3S,4S,5R,6R)-3,4,5-Trihydroxy-6-(3-((2S,4R)-4-hydroxy-1-methyl-5-oxopyrrolidin-2-yl)pyridin-1-ium-1-yl)tetrahydro-2H-pyran-2-carboxylate
- trans-3'-Hydroxy Cotinine N-?-D-Glucuronide
- 146275-18-5
- trans-3'-Hydroxy Cotinine N-b-D-Glucuronide
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- Inchi： 1S/C16H20N2O8/c1-18-8(7-3-2-4-17-6-7)5-9(14(18)22)25-16-12(21)10(19)11(20)13(26-16)15(23)24/h2-4,6,8-13,16,19-21H,5H2,1H3,(H,23,24)/t8-,9+,10-,11-,12+,13-,16+/m0/s1
- InChI Key： WALNNKZUGHYSCT-MGKNELHOSA-N
- SMILES： [C@@H]1(N(C)C(=O)[C@H](O[C@H]2[C@H](O)[C@H]([C@H](O)[C@@H](C(=O)O)O2)O)C1)C1=CN=CC=C1
Computed Properties
- Exact Mass: 368.12196560g/mol
- Monoisotopic Mass: 368.12196560g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 4
- Hydrogen Bond Acceptor Count: 8
- Heavy Atom Count: 26
- Rotatable Bond Count: 2
- Complexity: 555
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 7
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: -1.5
- Topological Polar Surface Area: 155?2
Experimental Properties
- Density: 1.6±0.1 g/cm3
- Melting Point: 188-189°C dec.
- Boiling Point: 699.2±55.0 °C at 760 mmHg
- Flash Point: 376.7±31.5 °C
- Solubility: Water (Slightly, Heated)
- Vapor Pressure: 0.0±2.3 mmHg at 25°C
trans-3'-Hydroxy Cotinine N-b-D-Glucuronide Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
- Storage Condition：Hygro°Cop°C, -20?°C Freezer, Under Inert Atmosphere
trans-3'-Hydroxy Cotinine N-b-D-Glucuronide Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | H924530-1mg |
trans-3'-Hydroxy Cotinine N-b-D-Glucuronide |
146275-18-5 | 1mg |
$ 856.00 | 2023-09-07 | ||
| TRC | H924530-2mg |
trans-3'-Hydroxy Cotinine N-b-D-Glucuronide |
146275-18-5 | 2mg |
$ 1478.00 | 2023-09-07 | ||
| TRC | H924530-5mg |
trans-3'-Hydroxy Cotinine N-b-D-Glucuronide |
146275-18-5 | 5mg |
$ 3818.00 | 2023-09-07 | ||
| Biosynth | MH07435-1 mg |
N-(trans-3-Hydroxycotinine)-b-D-glucuronide |
146275-18-5 | 1mg |
$866.25 | 2023-01-03 | ||
| Biosynth | MH07435-2 mg |
N-(trans-3-Hydroxycotinine)-b-D-glucuronide |
146275-18-5 | 2mg |
$1,582.36 | 2023-01-03 | ||
| Biosynth | MH07435-5 mg |
N-(trans-3-Hydroxycotinine)-b-D-glucuronide |
146275-18-5 | 5mg |
$3,811.50 | 2023-01-03 | ||
| SHENG KE LU SI SHENG WU JI SHU | sc-213086-1 mg |
trans-3'-Hydroxy Cotinine N-β-D-Glucuronide, |
146275-18-5 | 1mg |
￥8,649.00 | 2023-07-11 | ||
| SHENG KE LU SI SHENG WU JI SHU | sc-213086-1mg |
trans-3'-Hydroxy Cotinine N-β-D-Glucuronide, |
146275-18-5 | 1mg |
￥8649.00 | 2023-09-05 | ||
| A2B Chem LLC | AE84685-1mg |
trans-3'-Hydroxycotinine-N-b-D-glucuronide |
146275-18-5 | 1mg |
$952.00 | 2024-04-20 | ||
| A2B Chem LLC | AE84685-2mg |
trans-3'-Hydroxycotinine-N-b-D-glucuronide |
146275-18-5 | 2mg |
$1556.00 | 2024-04-20 |
trans-3'-Hydroxy Cotinine N-b-D-Glucuronide Related Literature
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Arezoo Habibagahi,Nicholas Alderman,Cariton Kubwabo Anal. Methods 2020 12 4276
Additional information on trans-3'-Hydroxy Cotinine N-b-D-Glucuronide
Recent Advances in the Study of trans-3'-Hydroxy Cotinine N-b-D-Glucuronide (CAS: 146275-18-5)
In recent years, the study of nicotine metabolites has gained significant attention due to their implications in smoking cessation therapies, biomarker development, and toxicological assessments. Among these metabolites, trans-3'-Hydroxy Cotinine N-b-D-Glucuronide (CAS: 146275-18-5) has emerged as a critical compound of interest. This research briefing aims to synthesize the latest findings on this metabolite, focusing on its biochemical properties, metabolic pathways, and potential applications in clinical and pharmacological settings.
The compound trans-3'-Hydroxy Cotinine N-b-D-Glucuronide is a glucuronide conjugate of trans-3'-hydroxycotinine, a major metabolite of nicotine. The glucuronidation process, mediated by UDP-glucuronosyltransferase (UGT) enzymes, enhances the water solubility of the metabolite, facilitating its excretion via urine. Recent studies have highlighted the role of this metabolite as a stable and reliable biomarker for nicotine exposure, offering advantages over other nicotine metabolites due to its longer half-life and higher concentration in biological fluids.
One of the key advancements in this field is the development of highly sensitive and specific analytical methods for quantifying trans-3'-Hydroxy Cotinine N-b-D-Glucuronide in biological samples. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become the gold standard for its detection, enabling researchers to achieve low limits of quantification and high precision. These methodological improvements have paved the way for large-scale epidemiological studies investigating the relationship between nicotine exposure and various health outcomes.
Furthermore, recent research has explored the pharmacokinetic and pharmacodynamic properties of trans-3'-Hydroxy Cotinine N-b-D-Glucuronide. Studies have demonstrated that individual variability in UGT enzyme activity can significantly influence the rate and extent of glucuronidation, leading to inter-individual differences in metabolite levels. This variability has important implications for personalized medicine, particularly in the context of smoking cessation therapies where metabolite levels may predict treatment efficacy.
In addition to its role as a biomarker, trans-3'-Hydroxy Cotinine N-b-D-Glucuronide has been investigated for its potential pharmacological effects. Some studies suggest that glucuronide metabolites may modulate the activity of nicotine and its derivatives, although the exact mechanisms remain under investigation. These findings open new avenues for research into the therapeutic applications of nicotine metabolites and their conjugates.
In conclusion, trans-3'-Hydroxy Cotinine N-b-D-Glucuronide (CAS: 146275-18-5) represents a promising area of research in the field of nicotine metabolism. Its utility as a biomarker, coupled with emerging insights into its pharmacological properties, underscores the importance of continued investigation. Future studies should focus on elucidating the mechanistic aspects of its action and exploring its potential applications in clinical practice.
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