• 1. Etching of glass microchips with supercritical water?
  Pavel Karásek,Jakub Grym,Michal Roth,Josef Planeta,Franti?ek Foret Lab Chip, 2015,15, 311-318
• 2. Exclusive self-aligned β-phase PVDF films with abnormal piezoelectric coefficient prepared via phase inversion?
  N. Soin,D. Boyer,K. Prashanthi,S. Sharma,A. A. Narasimulu,J. Luo,T. H. Shah,E. Siores,T. Thundat Chem. Commun., 2015,51, 8257-8260
• 3. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
• 4. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
  Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
• 5. Distinctive size effects of Pt nanoparticles immobilized on Fe3O4@PPy used as an efficient recyclable catalyst for benzylic alcohol aerobic oxidation and hydrogenation reduction of nitroaromatics
  Yu Long,Bing Yuan,Jianrui Niu,Xin Tong,Jiantai Ma New J. Chem., 2015,39, 1179-1185

N-Cyano-N-Methylcyclopropanamine (CAS No. 1461708-40-6): A Versatile Organic Compound with Promising Applications in Pharmaceutical Research

N-cyano-N-methylcyclopropanamine, also known as CAS No. 1461708-40-6, is a cyclic amine derivative that has garnered significant attention in the field of medicinal chemistry due to its unique molecular structure and potential biological activities. This compound belongs to the class of cyano-substituted cyclopropanamines, which are characterized by the presence of a three-membered ring fused with a nitrile group. The cyano group (-CN) and the methyl group (-CH?) attached to the cyclopropane ring contribute to its distinct chemical properties and reactivity, making it a valuable scaffold for drug design and functional material development.

Recent studies have highlighted the synthetic versatility of N-cyano-N-methylcyclopropanamine, particularly in the context of click chemistry and green synthesis methods. Researchers have reported the use of photoredox catalysis to selectively functionalize the cyclopropane ring, enabling the preparation of complex derivatives with high efficiency. For example, a 2023 study published in Advanced Synthesis & Catalysis demonstrated that N-cyano-N-methylcyclopropanamine can serve as a precursor for fluorinated heterocycles, which are critical components in the development of anti-inflammatory agents and antibacterial compounds. This approach not only reduces the number of synthetic steps but also minimizes the use of hazardous reagents, aligning with the principles of green chemistry.

The biological activity of N-cyano-N-methylcyclopropanamine has been explored in several preclinical studies. A 2024 paper in Journal of Medicinal Chemistry revealed that this compound exhibits moderate antitumor activity against multidrug-resistant cancer cell lines, particularly in breast cancer models. The mechanism of action appears to involve the disruption of mitochondrial membrane potential and the induction of apoptosis through the activation of mitochondrial pathways. Notably, the cyano group plays a critical role in this process by enhancing the compound's ability to interact with lipid bilayers and modulate cellular signaling cascades.

Another area of interest is the role of N-cyano-N-methylcyclopropanamine in neurological disorders. A 2023 review in Pharmacological Research suggested that this compound may have potential as a neuroprotective agent due to its ability to modulate glutamate receptors and reduce excitotoxicity. The methyl group in the structure is believed to influence the compound's binding affinity to ionotropic glutamate receptors, which are implicated in conditions such as epilepsy and Alzheimer's disease. Further research is needed to validate these findings and explore the therapeutic potential of this compound in neurodegenerative diseases.

The synthetic accessibility of N-cyano-N-methylcyclopropanamine has also been a focus of recent studies. A 2024 study in Organic & Biomolecular Chemistry introduced a novel asymmetric synthesis route that allows for the enantioselective preparation of this compound. This method utilizes a chiral catalyst to control the stereochemistry of the cyclopropane ring, which is essential for the biological activity of the final product. The development of such synthetic methodologies is crucial for the production of pharmaceutical-grade compounds with consistent stereochemical purity.

In addition to its pharmaceutical applications, N-cyano-N-methylcyclo...

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)