Cas no 146-17-8 (Riboflavine 5’-Phosphate)

Riboflavine 5’-Phosphate (R5P) is the biologically active form of vitamin B2 (riboflavin), serving as a cofactor for flavoproteins involved in redox reactions and energy metabolism. Its phosphorylated structure enhances bioavailability compared to standard riboflavin, ensuring efficient uptake and utilization in metabolic pathways. R5P is critical for electron transport, cellular respiration, and antioxidant defense systems. It is widely used in pharmaceutical formulations, nutraceuticals, and research applications due to its superior solubility and stability. The compound is particularly valuable in addressing riboflavin deficiencies and supporting mitochondrial function. Its role in FAD/FMN synthesis underscores its importance in enzymatic processes.
Riboflavine 5’-Phosphate structure
Riboflavine 5’-Phosphate structure
Product Name:Riboflavine 5’-Phosphate
CAS No:146-17-8
MF:C17H18N4O9P
MW:453.319984912872
CID:139800
PubChem ID:643976
Update Time:2025-05-21

Riboflavine 5’-Phosphate Chemical and Physical Properties

Names and Identifiers

    • Riboflavin5'-(dihydrogen phosphate)
    • FLAVIN MONONUCLEOTIDE
    • RIBOFLAVIN 5 PHOSPHATE
    • Flanin
    • flavin mononucleotide phosphate
    • flavinemononucleotide
    • Flavol
    • riboflavin mononucleotide
    • riboflavin-5'-monophosphate
    • RIBOFLAVIN-5'-PHOSPHATE
    • Riboflavine phosphate
    • riboflavinphosphate
    • sodium riboflavine monophosphate
    • vitamin B2 phosphate
    • RIBOFLAVIN 5′-MONPHOSPHATE
    • Riboflavin phosphate
    • riboflavinephosphate
    • Flavine mononucleotide
    • E101a
    • GTPL5185
    • Riboflavin-5-phosphate
    • C00061
    • {[(2R,3S,4S)-5-{7,8-dimethyl-2,4-dioxo-2H,3H,4H,10H-benzo[g]pteridin-10-yl}-2,3,4-trihydroxypentyl]oxy}phosphonic acid
    • 1azl
    • DTXSID8023559
    • CHEBI:17621
    • Vitamin B2 (riboflavin-5-phosphate)
    • Riboflavine phosphate (Riboflavine 5'-phosphate)
    • 1czl
    • Riboflavin 5'-phosphate
    • Benzo[g]pteridine, riboflavin 5'-(dihydrogen phosphate) deriv.
    • riboflavin-5-phosphate-sodium
    • Riboflavin 5'-(dihydrogen phosphate) (8CI,9CI)
    • Riboflavine 5'-monophosphate
    • Riboflavin 5'-(dihydrogen phosphate)
    • D-ribitol, 1-deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-, 5-(dihydrogen phosphate)
    • Flavinmononucleotid
    • Riboflavin, 5'-(dihydrogenphosphate)-
    • BRN 0068086
    • FMN
    • 1akq
    • 1akr
    • SCHEMBL21544837
    • RIBOFLAVIN PHOSPHATE [VANDF]
    • 1flm
    • FVTCRASFADXXNN-SCRDCRAPSA-N
    • Alloxazine mononucleotide
    • Riboflavin-5'-phosphate na
    • CHEMBL1201794
    • DB03247
    • Riboflavin5'-(dihydrogenphosphate)
    • 1nox
    • 1akw
    • Riboflavine-5'-phosphate
    • [(2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] dihydrogen phosphate
    • 1c7f
    • EN300-6477229
    • Q376061
    • 146-17-8
    • BDBM50421345
    • 1czr
    • EINECS 205-664-7
    • Riboflavine dihydrogen phosphate
    • UNII-7N464URE7E
    • Riboflavin 5''''-Phosphate
    • Riboflavine 5'-phosphate
    • Riboflavine 5-phosphate (6CI)
    • Riboflavin 5'-monophosphate
    • NS00069356
    • CS-0013780
    • Riboflavin monophosphate
    • 1czk
    • HY-B0964A
    • RIBOFLAVIN PHOSPHATE [WHO-DD]
    • Riboflavine monophosphate
    • AKOS027326698
    • 4-26-00-02554 (Beilstein Handbook Reference)
    • 1akt
    • FLAVIN MONONUCLEOTIDE [MI]
    • RIBOFLAVIN 5''-PHOSPHATE
    • 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-5-O-phosphono-D-ribitol
    • 7N464URE7E
    • (2R,3S,4S)-5-(7,8-Dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-2,3,4-trihydroxypentyl dihydrogen phosphate
    • SCHEMBL41133
    • riboflavin 5'-monophosphate(3-)
    • flavin mononucleotide trianion
    • flavin mononucleotide(3-)
    • riboflavin 5'-monophosphate trianion
    • 7,8-dimethyl-2,4-dioxo-10-[(2S,3S,4R)-2,3,4-trihydroxy-5-(phosphonatooxy)pentyl]-2H,3H,4H,10H-benzo[g]pteridin-3-ide
    • riboflavin 5'-phosphate(3-)
    • 6184-17-4
    • riboflavin 5'-phosphate trianion
    • FMN trianion
    • BRD-K09229706-236-02-6
    • G77462
    • 1ST2571
    • BRD-K09229706-236-01-8
    • Riboflavine 5’-Phosphate
    • MDL： MFCD00022260
    • Inchi： InChI=1S/C17H21N4O9P/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29)/t11-,12+,14-/m0/s1
    • InChI Key： FVTCRASFADXXNN-SCRDCRAPSA-N
    • SMILES： CC1=CC2=C(C=C1C)N=C(C(N2C[C@@H]([C@@H]([C@@H](COP(O)(O)=O)O)O)O)=N3)C(NC3=O)=O

Computed Properties

  • Exact Mass: 456.10500
  • Monoisotopic Mass: 456.10461526g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 6
  • Hydrogen Bond Acceptor Count: 13
  • Heavy Atom Count: 31
  • Rotatable Bond Count: 7
  • Complexity: 844
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 3
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: -2.6
  • Topological Polar Surface Area: 202?2

Experimental Properties

  • Density: 1.8±0.1 g/cm3
  • PSA: 217.90000
  • LogP: -1.55820

Riboflavine 5’-Phosphate Security Information

Riboflavine 5’-Phosphate Pricemore >>

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Riboflavine 5’-Phosphate Suppliers

Amadis Chemical Company Limited
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(CAS:146-17-8)Riboflavine 5’-Phosphate
Order Number:A922344
Stock Status:in Stock
Quantity:1g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 14:32
Price ($):489.0

Riboflavine 5’-Phosphate Related Literature

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Additional information on Riboflavine 5’-Phosphate

Comprehensive Overview of Riboflavine 5’-Phosphate (CAS No. 146-17-8): Properties, Applications, and Innovations

Riboflavine 5’-Phosphate, also known as Flavin Mononucleotide (FMN), is a biologically active form of vitamin B2 (Riboflavin). With the CAS number 146-17-8, this compound plays a critical role in cellular energy production and metabolic processes. Its phosphorylated structure enhances solubility and bioavailability, making it a preferred choice in nutraceutical, pharmaceutical, and food fortification applications. Recent trends in personalized nutrition and functional foods have driven demand for this ingredient, as consumers seek science-backed solutions for energy metabolism and antioxidant support.

The chemical structure of Riboflavine 5’-Phosphate includes a phosphate group at the 5’ position of the ribityl side chain, which distinguishes it from standard Riboflavin. This modification allows for direct utilization in enzymatic reactions, particularly in the electron transport chain and mitochondrial function. Researchers highlight its superiority in clinical settings where rapid absorption is required, such as in parenteral nutrition formulations. A 2023 study published in the Journal of Nutritional Biochemistry emphasized its efficacy in addressing riboflavin deficiency compared to non-phosphorylated analogs.

In the cosmeceutical industry, CAS 146-17-8 has gained attention for its skin-revitalizing properties. Its role in collagen synthesis and protection against oxidative stress aligns with the growing market for anti-aging products. Formulators increasingly combine it with hyaluronic acid and niacinamide to enhance skin barrier function—a topic trending in dermatology forums and beauty influencer content. Google search data reveals a 40% year-on-year increase in queries like "Riboflavine Phosphate for glowing skin" and "FMN vs Riboflavin bioavailability."

Industrial production of Riboflavine 5’-Phosphate involves enzymatic phosphorylation or chemical synthesis under controlled conditions. Manufacturers must adhere to GMP certification and pharmacopeial standards (USP/EP) to ensure purity levels exceeding 98%. Analytical techniques like HPLC-UV and mass spectrometry are employed for quality control, addressing concerns about heavy metal contaminants—a frequent subject in FDA regulatory updates. The compound’s stability profile in low-pH formulations makes it suitable for energy drink fortification, a segment projected to grow at 6.8% CAGR through 2030.

Emerging research explores 146-17-8’s potential in neurological health. A 2024 preclinical trial demonstrated its neuroprotective effects by modulating glutathione reductase activity, sparking interest in mitochondrial disorders therapeutics. This aligns with rising searches for "FMN and cognitive function" and "vitamin B2 phosphate migraine prevention." Meanwhile, vegan supplement brands emphasize its plant-derived variants to cater to ethical consumerism trends.

From a regulatory perspective, Riboflavine 5’-Phosphate holds GRAS status in food applications and is listed in the EU Approved Food Additives database (E101a). Its inclusion in WHO Essential Medicines List underscores its therapeutic importance. Storage recommendations emphasize protection from UV light degradation, with amber glass packaging being industry-standard—a detail frequently overlooked in supplement manufacturing discussions but critical for potency retention.

The future of CAS 146-17-8 lies in nanotechnology applications. Recent patents describe FMN-loaded liposomes for enhanced transdermal delivery, while biotech startups investigate its use in bioelectronic medicine due to flavoprotein redox properties. These innovations respond to market demands for precision nutrition and next-gen therapeutics, positioning Riboflavine 5’-Phosphate as a multifaceted ingredient at the intersection of biochemistry and material science.

146-17-8 (Riboflavine 5’-Phosphate) Related Products

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Amadis Chemical Company Limited
(CAS:146-17-8)Riboflavine 5’-Phosphate
A922344
Purity:99%
Quantity:1g
Price ($):489.0
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