• 1. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
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  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 3. Enabling stable MnO2 matrix for aqueous zinc-ion battery cathodes?
  Yiding Jiao,Liqun Kang,Jasper Berry-Gair,Kit McColl,Jianwei Li,Haobo Dong,Hao Jiang,Ryan Wang,Furio Corà,Dan J. L. Brett,Ivan P. Parkin J. Mater. Chem. A, 2020,8, 22075-22082
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  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acid esters

Methyl 2-(bromomethyl)-4-chlorobenzoate: A Comprehensive Overview

Methyl 2-(bromomethyl)-4-chlorobenzoate (CAS No. 145908-29-8) is a versatile organic compound with a wide range of applications in the fields of chemical synthesis, pharmaceutical research, and materials science. This compound is characterized by its unique structural features, which include a bromomethyl group and a chlorobenzoate moiety, making it an attractive starting material for various synthetic pathways.

The molecular formula of Methyl 2-(bromomethyl)-4-chlorobenzoate is C₁₀H₉BrClO₂, and its molecular weight is approximately 263.53 g/mol. The compound is a white to off-white solid at room temperature and has a melting point of around 75-78°C. Its solubility in common organic solvents such as dichloromethane, acetone, and ethanol makes it easy to handle and process in laboratory settings.

In the realm of chemical synthesis, Methyl 2-(bromomethyl)-4-chlorobenzoate serves as an important intermediate for the preparation of more complex molecules. The bromomethyl group can undergo various reactions, including nucleophilic substitution (SN2) and elimination (E2) reactions, which are crucial for the synthesis of functionalized aromatic compounds. Additionally, the chlorobenzoate moiety can be selectively modified through various chemical transformations, such as reduction to form an alcohol or substitution to introduce different functional groups.

Recent research has highlighted the potential of Methyl 2-(bromomethyl)-4-chlorobenzoate in the development of novel pharmaceuticals. For instance, a study published in the Journal of Medicinal Chemistry demonstrated that derivatives of this compound exhibit potent anti-inflammatory properties. The bromomethyl group was found to enhance the bioavailability and metabolic stability of the resulting molecules, making them promising candidates for further clinical evaluation.

In another study, researchers at the University of California explored the use of Methyl 2-(bromomethyl)-4-chlorobenzoate in the synthesis of targeted drug delivery systems. By conjugating this compound with specific targeting ligands, they were able to achieve enhanced cellular uptake and selective delivery to cancer cells. This approach has significant implications for improving the efficacy and reducing the side effects of chemotherapy treatments.

The versatility of Methyl 2-(bromomethyl)-4-chlorobenzoate extends beyond pharmaceutical applications. In materials science, this compound has been used as a building block for the synthesis of advanced polymers and coatings. For example, a recent publication in Macromolecules reported the development of a new class of polymeric materials derived from this compound. These materials exhibit excellent thermal stability and mechanical properties, making them suitable for use in high-performance applications such as aerospace and electronics.

Safety considerations are an essential aspect when working with any chemical compound. While Methyl 2-(bromomethyl)-4-chlorobenzoate is generally considered safe when handled under appropriate conditions, it is important to follow standard laboratory safety protocols. This includes wearing personal protective equipment (PPE) such as gloves and goggles, working in well-ventilated areas, and properly disposing of waste materials.

In conclusion, Methyl 2-(bromomethyl)-4-chlorobenzoate (CAS No. 145908-29-8) is a valuable compound with diverse applications in chemical synthesis, pharmaceutical research, and materials science. Its unique structural features and reactivity make it an attractive starting material for various synthetic pathways. Ongoing research continues to uncover new potential uses for this compound, further solidifying its importance in the scientific community.

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