• 1. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 2. An analyte-triggered artificial peroxidase system based on dimanganese complex for a versatile enzyme assay?
  Suji Lee,Min Su Han Chem. Commun., 2021,57, 9450-9453
• 3. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 4. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 5. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Thiophenes Thiophene carboxylic acids and derivatives

Ethyl 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate (CAS No. 14559-12-7): A Comprehensive Overview

Ethyl 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate (CAS No. 14559-12-7) is a significant compound in the realm of organic chemistry and pharmaceutical research. This compound, characterized by its intricate molecular structure, has garnered considerable attention due to its potential applications in drug development and synthetic chemistry. The benzothiophene core of this molecule imparts unique electronic and steric properties, making it a valuable scaffold for designing novel bioactive molecules.

The chemical structure of Ethyl 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate consists of a fused ring system comprising a benzene ring and a thiophene ring, with a carboxylate ester group at the 3-position and an ethyl substituent at the 3'-position. This arrangement contributes to its stability and reactivity, enabling diverse chemical transformations that are pivotal for synthetic applications. The presence of the tetrahydropyran ring further enhances its versatility, allowing for modifications that can fine-tune its pharmacological properties.

In recent years, there has been a surge in research focusing on heterocyclic compounds due to their widespread presence in natural products and pharmaceuticals. Among these, benzothiophene derivatives have been extensively studied for their potential as intermediates in the synthesis of bioactive molecules. Specifically, Ethyl 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate has been explored as a precursor in the development of compounds with therapeutic implications. Its structural features make it an attractive candidate for further functionalization to create molecules with enhanced binding affinity and selectivity.

One of the most compelling aspects of this compound is its role in the synthesis of kinase inhibitors. Kinases are enzymes that play crucial roles in cell signaling pathways and are often targeted in the treatment of various diseases, including cancer. Researchers have leveraged the benzothiophene scaffold of Ethyl 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate to develop novel inhibitors that exhibit potent activity against specific kinases. These inhibitors have shown promise in preclinical studies and are being further optimized for clinical applications.

The ester group at the 3-position of Ethyl 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate provides a versatile handle for further chemical modifications. This functionality can be hydrolyzed to yield the corresponding carboxylic acid or transesterified to introduce different alkyl groups. Such modifications are essential for tailoring the physicochemical properties of derived compounds, including solubility, permeability, and metabolic stability. These attributes are critical factors that determine the efficacy and safety of pharmaceutical candidates.

In addition to its applications in drug development, Ethyl 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate has found utility in materials science. The unique electronic properties of benzothiophene derivatives make them suitable candidates for organic semiconductors and light-emitting diodes (OLEDs). Researchers have incorporated this compound into polymer blends to enhance charge transport properties and improve device performance. The ability to fine-tune these properties through structural modifications has opened up new possibilities for advanced materials applications.

The synthesis of Ethyl 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate typically involves multi-step organic reactions starting from readily available precursors. Common synthetic routes include cyclization reactions followed by esterification steps. Advances in catalytic methods have enabled more efficient and sustainable synthetic pathways, reducing the environmental impact of production processes. These improvements align with the growing emphasis on green chemistry principles in industrial applications.

The pharmacological profile of derivatives derived from Ethyl 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate continues to be an area of active investigation. Preclinical studies have demonstrated the potential of certain analogs as modulators of neurological disorders and inflammatory conditions. The benzothiophene core is known to interact with biological targets in unique ways due to its aromaticity and heteroatom composition. This interaction profile makes it a valuable scaffold for designing molecules with specific therapeutic effects.

In conclusion,Ethyl 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate (CAS No.14559-12-7) is a multifaceted compound with significant implications in pharmaceutical research and materials science. Its structural features enable diverse functionalizations that are pivotal for developing bioactive molecules and advanced materials. As research continues to uncover new applications for this compound and its derivatives,Ethyl 4,

• 173724-69-1(3-Thiophenecarboxylic acid, 2-(1-methylethyl)-5-octyl-4-phenyl-, ethylester)
• 438213-69-5(6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic Acid)
• 19156-47-9(Ethyl 5-(2-acetoxyethyl)-4-methylthiophene-3-carboxylate)
• 19156-54-8(4,5,6,7-Tetrahydro-1-benzothiophene-3-carboxylic Acid)
• 923792-95-4(6-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid)
• 158875-40-2(3-Thiophenecarboxylic acid, 2-propyl-, ethyl ester)
• 158875-41-3(3-Thiophenecarboxylic acid, 2-(1-methylethyl)-, ethyl ester)
• 187664-40-0(Benzo[b]thiophene-3-carboxylic acid, 4,5,6,7-tetrahydro-2-methyl-, ethylester)
• 19156-53-7(4H,5H,6H-cyclopenta[b]thiophene-3-carboxylic acid)
• 105568-23-8(Benzo[b]thiophene-2,3-dicarboxylic acid, 4,5,6,7-tetrahydro-, dimethylester)