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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzene and substituted derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Chemical Profile of (1S)-1-phenylethan-1-ol (CAS No. 1445-91-6)

The compound (1S)-1-phenylethan-1-ol, identified by its CAS number 1445-91-6, is a significant molecule in the field of organic chemistry and pharmaceutical research. This chiral alcohol, also known as l-phenylethyl alcohol, has garnered attention due to its unique structural and functional properties. The enantiomeric purity of this compound is particularly crucial in medicinal chemistry, where stereochemistry often dictates the efficacy and safety of drug candidates.

In recent years, the demand for high-purity chiral intermediates has surged, driven by advancements in drug discovery and development. The synthesis and characterization of enantiomerically pure compounds like (1S)-1-phenylethan-1-ol have become cornerstone techniques in modern pharmaceutical research. This compound serves as a versatile building block for the synthesis of more complex molecules, including potential therapeutic agents.

The chemical structure of (1S)-1-phenylethan-1-ol consists of a phenyl group attached to an ethyl chain with an (S)-configuration at the chiral center. This configuration imparts specific interactions with biological targets, making it a valuable scaffold for designing novel pharmacophores. The compound's ability to participate in hydrogen bonding and other non-covalent interactions further enhances its utility in medicinal chemistry.

Recent studies have highlighted the role of (1S)-1-phenylethan-1-ol in the development of central nervous system (CNS) therapeutics. Its structural motif is found in several psychoactive compounds, suggesting potential applications in neuropharmacology. Researchers have explored its derivatives as candidates for treating neurological disorders, leveraging its chiral properties to modulate receptor binding affinities.

The synthesis of (1S)-1-phenylethan-1-ol typically involves asymmetric reduction or resolution techniques to achieve high enantiomeric purity. Advances in catalytic methods, such as transition metal-catalyzed reductions, have improved the efficiency and scalability of these processes. These innovations are critical for producing sufficient quantities of the compound for both research and industrial applications.

Analytical techniques play a pivotal role in characterizing the purity and stereochemistry of (1S)-1-phenylethan-1-ol. Chiral chromatography, nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry are commonly employed to confirm the identity and enantiomeric excess of the compound. Such rigorous analytical methods ensure that researchers can proceed with confidence in their synthetic and pharmacological studies.

In addition to its pharmaceutical applications, (1S)-1-phenylethan-1-ol has found utility in other areas of chemical research. Its role as a ligand in asymmetric catalysis has been explored, where it aids in controlling reaction outcomes through steric and electronic effects. This dual functionality makes it a valuable asset in both synthetic organic chemistry and medicinal chemistry.

The growing interest in green chemistry has also influenced the synthesis of (1S)-1-phenylethan-1-ol. Researchers are increasingly adopting environmentally friendly protocols that minimize waste and energy consumption. Such sustainable approaches align with global efforts to promote sustainable chemical manufacturing practices.

Future directions in the study of (1S)-1-phenylethan-1-ol may include exploring its biological activity further. Preclinical studies could investigate its potential as an intermediate for developing new drugs or as a tool compound for understanding enzyme mechanisms. The compound's unique properties make it a promising candidate for innovative research across multiple disciplines.

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• 17537-32-5((±)-1-Phenylethan-2,2,2-d3-ol)
• 3101-96-0((±)-1-Phenylethan-1-d1-ol)
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• 219586-41-1((±)-1-Phenylethanol-d10)
• 19547-01-4(Benzene-d5-methan-d-ol,a-(methyl-d3)- (9CI))
• 7287-81-2(1-(3-Methylphenyl)ethanol)
• 13323-81-4(1-Phenylethanol)
• 285138-87-6(Benzenemethanol-13C, a-(methyl-13C)- (9CI))