• 1. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 2. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 3. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
  Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
• 4. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 5. An alternative biorefinery approach to address microalgal seasonality: blending with spent coffee grounds
  Andre Prates Pereira,Tao Dong,Eric P. Knoshaug,Nick Nagle,Ryan Spiller,Bonnie Panczak,Christopher J. Chuck,Philip T. Pienkos Sustainable Energy Fuels, 2020,4, 3400-3408

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazanaphthalenes Cinnolines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazanaphthalenes Benzodiazines Cinnolines

Comprehensive Guide to 4-[(prop-2-en-1-yl)amino]cinnoline-3-carboxylic acid (CAS No. 1443980-57-1): Properties, Applications, and Market Insights

4-[(prop-2-en-1-yl)amino]cinnoline-3-carboxylic acid (CAS No. 1443980-57-1) is a specialized cinnoline derivative with significant potential in pharmaceutical and biochemical research. This compound belongs to the heterocyclic carboxylic acid family, characterized by its unique cinnoline core and allylamino substitution. Researchers are increasingly interested in this molecule due to its structural versatility and potential applications in drug discovery.

The molecular structure of 4-[(prop-2-en-1-yl)amino]cinnoline-3-carboxylic acid features a cinnoline ring system with a carboxylic acid group at position 3 and an allylamino substituent at position 4. This arrangement provides both hydrogen bond donor/acceptor capabilities and reactivity for further derivatization, making it valuable for medicinal chemistry applications. The compound's molecular weight and logP value suggest favorable drug-like properties, aligning with current trends in small molecule therapeutics development.

In pharmaceutical research, 4-[(prop-2-en-1-yl)amino]cinnoline-3-carboxylic acid serves as a key intermediate for developing novel kinase inhibitors and signaling pathway modulators. Recent studies highlight its potential in addressing age-related diseases and metabolic disorders, topics currently trending in scientific literature. The compound's cinnoline scaffold is particularly interesting for designing selective enzyme inhibitors, as demonstrated in several patent applications for anti-inflammatory agents.

The synthesis of 4-[(prop-2-en-1-yl)amino]cinnoline-3-carboxylic acid typically involves multi-step organic transformations starting from commercially available cinnoline precursors. Modern green chemistry approaches are being explored to optimize its production, reflecting the growing demand for sustainable pharmaceutical manufacturing. Analytical characterization using HPLC-MS and NMR spectroscopy confirms the compound's high purity, essential for research applications.

Market analysis indicates rising demand for specialty heterocyclic compounds like 4-[(prop-2-en-1-yl)amino]cinnoline-3-carboxylic acid, driven by increased drug discovery activities worldwide. The compound's CAS registry number 1443980-57-1 serves as a unique identifier in chemical databases and patent documents. Suppliers typically offer this material in milligram to kilogram quantities, with purity levels ranging from 95% to 99% for different research needs.

From a drug design perspective, the allylamino group in 4-[(prop-2-en-1-yl)amino]cinnoline-3-carboxylic acid provides opportunities for click chemistry modifications, a popular technique in modern bioconjugation and probe development. This feature aligns with current interests in targeted drug delivery systems and theranostic applications. Researchers are exploring its potential in personalized medicine approaches, particularly for cancer therapeutics and neurodegenerative disease research.

Storage and handling of 4-[(prop-2-en-1-yl)amino]cinnoline-3-carboxylic acid require standard laboratory precautions for organic compounds. The material is typically stable at room temperature when protected from moisture and light, with recommended storage in amber glass containers under inert atmosphere for long-term preservation. These handling protocols follow current best practices for research chemicals management.

The intellectual property landscape surrounding cinnoline derivatives like 4-[(prop-2-en-1-yl)amino]cinnoline-3-carboxylic acid has grown significantly, with numerous patent filings in recent years covering various therapeutic applications. This reflects the compound's importance in innovative drug development and the pharmaceutical industry's focus on novel chemical entities. Academic publications referencing this compound have increased steadily, particularly in journals focusing on medicinal chemistry and drug design.

Future research directions for 4-[(prop-2-en-1-yl)amino]cinnoline-3-carboxylic acid may explore its potential in combination therapies and multi-target drugs, addressing complex diseases through polypharmacology approaches. The compound's structural flexibility makes it suitable for library synthesis in high-throughput screening campaigns. These applications position it as a valuable tool in the ongoing search for next-generation therapeutics against challenging medical conditions.

Quality control protocols for 4-[(prop-2-en-1-yl)amino]cinnoline-3-carboxylic acid typically involve chromatographic purity assessment and spectroscopic confirmation of structure. The compound's analytical standards are increasingly available to support method development in pharmaceutical analysis. This availability facilitates its use in regulatory submissions and quality assurance programs within drug development pipelines.

In conclusion, 4-[(prop-2-en-1-yl)amino]cinnoline-3-carboxylic acid (CAS No. 1443980-57-1) represents an important building block in modern medicinal chemistry with diverse potential applications. Its unique chemical structure and functional group arrangement offer numerous opportunities for molecular innovation in drug discovery. As research continues to uncover new therapeutic possibilities for cinnoline-based compounds, this particular derivative is poised to play a significant role in advancing pharmaceutical science and biomedical research.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)