• 1. Periselectivity between the [1,4] and [3,3] thermal sigmatropic rearrangements of 2-allyloxypyridine N-oxides
  David Alker,W. David Ollis,Hooshang Shahriari-Zavareh J. Chem. Soc. Perkin Trans. 1 1990 1623
• 2. Forchlorfenuron-mimicking haptens: from immunogen design to antibody characterization by hierarchical clustering analysis
  Celia Suárez-Pantaleón,Josep V. Mercader,Consuelo Agulló,Antonio Abad-Somovilla,Antonio Abad-Fuentes Org. Biomol. Chem. 2011 9 4863
• 3. Notes
  N. Pravdi?,D. Keglevi?,E. D. Andrews,W. E. Harvey,Roger Bolton,A. F. Casy,J. L. Myers,D. W. Mathiwson,W. B. Whalley,J. M. Blatchly,R. Taylor,A. B. A. Jansen,P. J. Stokes,G. W. H. Cheeseman,J. S. Davidson,J. M. Crabtree,P. N. Gates,E. F. Mooney,J. K. Sutherland,D. A. Widdowson,Stang Mongkolsuk,F. M. Dean,G. W. Kirby,H. P. Tiwari,D. J. Machin,D. F. C. Morris,E. L. Short,R. S. Bluck,A. L. Odell,R. W. Olliff,J. Burdon,W. B. Hollyhead,C. R. Patrick,J. A. Salthouse,T. C. Waddington,Shreekrishna M. Gadedar,Anna Marie Kotsen,Elliott Cohen J. Chem. Soc. 1964 4633
• 4. [1,4] and [5,5] thermal sigmatropic rearrangements of 2-pentadienyloxypyridine N-oxides
  David Alker,W. David Ollis,Hooshang Shahriari-Zavareh J. Chem. Soc. Perkin Trans. 1 1990 1637

2-Chloro-4-Nitropyridine-N-Oxide (CAS No. 14432-16-7)

2-Chloro-4-Nitropyridine-N-Oxide is a highly specialized organic compound with the CAS registry number 14432-16-7. This compound belongs to the class of pyridine derivatives, which are widely studied for their unique chemical properties and potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science. The molecular structure of 2-chloro-4-nitropyridine-n-oxide consists of a pyridine ring with a chlorine atom at the 2-position and a nitro group at the 4-position, along with an oxygen atom in the N-oxide configuration. This arrangement imparts the compound with distinct electronic and steric properties, making it a valuable substrate for further chemical modifications.

The synthesis of 2-chloro-4-nitropyridine-n-oxide typically involves multi-step reactions, often starting from pyridine derivatives and incorporating functional groups through electrophilic substitution or other methods. Recent advancements in synthetic chemistry have enabled more efficient and selective routes to prepare this compound, reducing production costs and minimizing environmental impact. For instance, researchers have explored the use of microwave-assisted synthesis and catalytic systems to enhance reaction yields and purity levels.

One of the most promising applications of 2-chloro-4-nitropyridine-n-oxide lies in its use as an intermediate in the synthesis of bioactive molecules. The compound's functional groups provide excellent sites for further derivatization, allowing chemists to design molecules with specific pharmacological properties. For example, studies have shown that derivatives of this compound exhibit potent antimicrobial activity against various bacterial strains, making them potential candidates for antibiotic development.

In addition to its role in drug discovery, 2-chloro-4-nitropyridine-n-oxide has also been investigated for its potential in agrochemicals. The compound's ability to act as a precursor for herbicides or fungicides has been explored in recent research, particularly due to its stability under environmental conditions and its capacity to interact with biological targets effectively. Field trials have demonstrated promising results, suggesting that derivatives of this compound could offer sustainable solutions for crop protection.

The chemical stability and reactivity of 2-chloro-4-nitropyridine-n-oxide make it an attractive candidate for materials science applications as well. For instance, researchers have examined its use in the synthesis of advanced polymers and hybrid materials with tailored electronic properties. By incorporating this compound into polymer matrices, scientists aim to develop materials with enhanced conductivity or mechanical strength, suitable for use in electronic devices or structural composites.

From an environmental standpoint, understanding the fate and transport of 2-chloro-4-nitropyridine-n oxide is crucial for assessing its potential impact on ecosystems. Studies have shown that the compound undergoes rapid degradation under aerobic conditions, minimizing its persistence in natural environments. However, further research is needed to evaluate its behavior under various environmental scenarios and to develop strategies for safe handling and disposal.

In conclusion, 2-chloro-4-nitropyridine-n oxide (CAS No. 14432 16 7) is a versatile compound with significant potential across multiple disciplines. Its unique chemical properties, coupled with recent advancements in synthetic methods and application development, position it as a key player in modern chemical research. As ongoing studies continue to uncover new insights into its behavior and utility, this compound is poised to play an increasingly important role in shaping future innovations across industries.

• 5470-66-6(2-methyl-4-nitropyridine-n-oxide)
• 1596-52-7(Quinoline,4,6-dinitro-, 1-oxide)
• 138835-34-4(Naphth[2,1,8-mna]acridine,3-nitro-, 6-oxide)
• 138835-33-3(Naphth[2,1,8-mna]acridine,1-nitro-, 6-oxide)
• 14753-17-4(7-nitroquinolin-1-ium-1-olate)
• 1124-82-9(3-Oxabicyclo[3.2.0]heptane-2,4-dione,1,5-dibromo-)
• 1074-98-2(3-methyl-4-nitro-1-oxido-pyridin-1-ium)
• 1122-61-8(4-nitropyridine)
• 1124-33-0(4-Nitropyridine N-oxide)
• 13673-29-5(Pyridine, 4-nitroso-,1-oxide)