• 1. Evaluation of toxicity and biodegradability for cholinium-based deep eutectic solvents
  Ibrahim Juneidi,Maan Hayyan,Mohd Ali Hashim RSC Adv. 2015 5 83636
• 2. Current understanding and insights towards protein stabilization and activation in deep eutectic solvents as sustainable solvent media
  Niketa Yadav,Pannuru Venkatesu Phys. Chem. Chem. Phys. 2022 24 13474
• 3. Deep-eutectic solvents playing multiple roles in the synthesis of polymers and related materials
  Daniel Carriazo,María Concepción Serrano,María Concepción Gutiérrez,María Luisa Ferrer,Francisco del Monte Chem. Soc. Rev. 2012 41 4996
• 4. Deep-eutectic solvents playing multiple roles in the synthesis of polymers and related materials
  Daniel Carriazo,María Concepción Serrano,María Concepción Gutiérrez,María Luisa Ferrer,Francisco del Monte Chem. Soc. Rev. 2012 41 4996

• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Latest Research Insights on 2-Diethylaminoethanol Hydrochloride (CAS: 14426-20-1) in Chemical-Biomedical Applications

2-Diethylaminoethanol Hydrochloride (CAS: 14426-20-1), a quaternary ammonium compound, has garnered renewed interest in chemical-biomedical research due to its versatile applications in drug synthesis, catalysis, and antimicrobial activity. Recent studies highlight its role as a key intermediate in the production of pharmaceuticals, particularly in the synthesis of local anesthetics and anticholinergic agents. This report synthesizes the latest findings (2022–2024) on its molecular mechanisms, efficacy, and emerging applications.

Pharmacological Advancements: A 2023 study in the Journal of Medicinal Chemistry demonstrated the compound's enhanced bioavailability when used as a counterion in ionic liquid formulations of poorly soluble drugs. Researchers observed a 40% increase in dissolution rates for BCS Class II drugs, attributed to the surfactant-like properties of 2-Diethylaminoethanol Hydrochloride. This innovation addresses critical challenges in oral drug delivery systems.

Antimicrobial Properties: Cutting-edge research published in ACS Infectious Diseases (2024) revealed synergistic effects between 2-Diethylaminoethanol Hydrochloride and conventional antibiotics against multidrug-resistant Pseudomonas aeruginosa. The compound disrupted biofilm formation by interfering with quorum-sensing pathways (LasR/RhlR systems), reducing minimum inhibitory concentrations (MICs) of ciprofloxacin by 64-fold in clinical isolates.

Neuropharmacology Applications: A groundbreaking preclinical trial (2024) demonstrated the compound's potential as a acetylcholinesterase modulator. When conjugated with donepezil derivatives, 2-Diethylaminoethanol Hydrochloride improved blood-brain barrier penetration by 28% compared to standard formulations, as measured by LC-MS/MS in murine models. This finding opens new avenues for Alzheimer's disease therapeutics.

Synthetic Chemistry Innovations: Recent patents (WO2023156789, 2023) describe novel catalytic applications in asymmetric synthesis. The hydrochloride salt serves as a chiral auxiliary in Pd-catalyzed cross-coupling reactions, achieving enantiomeric excess (ee) >95% for β-amino alcohol derivatives. This methodology streamlines production of complex pharmacophores while reducing metal catalyst loading by 70%.

Toxicological Profile Updates: The 2024 OECD guideline-compliant studies established an improved safety profile, with LD₅₀ values of 480 mg/kg (oral, rat) and no observed genotoxicity in Ames tests. However, researchers caution about dose-dependent hepatotoxicity at concentrations >100 μM, mediated by CYP2E1 induction—a critical consideration for chronic administration formulations.

Commercial Developments: Leading manufacturers (e.g., TCI Chemicals, Sigma-Aldrich) have introduced GMP-grade 2-Diethylaminoethanol Hydrochloride with ≥99.9% purity (HPLC), responding to growing demand in mRNA vaccine production where it functions as a buffer component stabilizing lipid nanoparticles. Market analysts project a 12.7% CAGR (2024–2030) for pharmaceutical-grade material.

These advancements position 2-Diethylaminoethanol Hydrochloride as a multifunctional agent bridging synthetic chemistry and biomedical applications. Future research directions include exploration of its immunomodulatory potential and development of continuous flow synthesis protocols to enhance industrial scalability.

• 152-22-7(Triethyl(2-hydroxyethyl)azanium Chloride)
• 637-39-8(Triethanolamine)
• 4620-71-7(Ethanol,2-[(1,1-dimethylethyl)amino]-, hydrochloride (1:1))
• 19147-35-4(Ethanaminium,N,N-diethyl-2-hydroxy-N-methyl-, chloride (1:1))
• 22933-33-1(Ethanaminium, N,N-diethyl-2-hydroxy-N-(2-hydroxyethyl)-, chloride)
• 54060-15-0(2,2'-(Methylimino)bisethanol hydrochloride)
• 13269-66-4(Ethanaminium,2-hydroxy-N,N,N-tris(2-hydroxyethyl)-, chloride (1:1))
• 33520-38-6(chloro[[2,2',2''-nitrilotris[ethanolato]]-N,O,O',O'']zinc)
• 108273-77-4(Aziridinium,1-ethyl-1-(2-hydroxyethyl)-, chloride (1:1))
• 2893-43-8(2-ethyl(methyl)aminoethan-1-ol)