Cas no 144243-28-7 (3-(1-Pyrrolidinyl)-piperidine Dihydrochloride)

3-(1-Pyrrolidinyl)-piperidine Dihydrochloride is a versatile organic compound featuring a pyrrolidine-piperidine hybrid structure, commonly utilized in pharmaceutical and chemical research. Its dihydrochloride salt form enhances solubility and stability, making it suitable for synthetic applications and biological studies. The compound serves as a valuable intermediate in the development of bioactive molecules, particularly in medicinal chemistry for targeting central nervous system (CNS) receptors. Its rigid bicyclic framework provides a scaffold for structural modifications, enabling precise tuning of pharmacological properties. The high purity and well-defined characterization of this compound ensure reproducibility in research applications. Its utility in ligand design and drug discovery underscores its importance in academic and industrial settings.
3-(1-Pyrrolidinyl)-piperidine Dihydrochloride structure
144243-28-7 structure
Product Name:3-(1-Pyrrolidinyl)-piperidine Dihydrochloride
CAS No:144243-28-7
MF:C9H18N2
MW:154.252622127533
MDL:MFCD09998985
CID:1087598
PubChem ID:573611
Update Time:2025-05-24

3-(1-Pyrrolidinyl)-piperidine Dihydrochloride Chemical and Physical Properties

Names and Identifiers

    • 3-(Pyrrolidin-1-yl)piperidine
    • 3-(1-pyrrolidinyl)piperidine(SALTDATA: 2HCl)
    • 3-Pyrrolidin-1-yl-piperidine
    • 3-(1-pyrrolidinyl)piperidine
    • 3-(1-PYRROLIDINYL)-PIPERIDINE
    • Azacyclohexane, 3-[1-pyrrolidyl]-
    • J-007938
    • MFCD09998985
    • AKOS000302429
    • CS-0216432
    • SB41281
    • 3-(1-Pyrrolidinyl)piperidine #
    • DB-348464
    • Z415658484
    • EN300-42929
    • SCHEMBL2328636
    • 3-(1-Pyrrolidinyl)-piperidine 2HCl
    • 144243-28-7
    • AKOS022185266
    • BS-13495
    • 3-pyrrolidin-1-ylpiperidine
    • 3-(1-Pyrrolidinyl)-piperidine Dihydrochloride
    • MDL： MFCD09998985
    • Inchi： 1S/C9H18N2/c1-2-7-11(6-1)9-4-3-5-10-8-9/h9-10H,1-8H2
    • InChI Key： DSRVXZMXCPNZDO-UHFFFAOYSA-N
    • SMILES： N1(CCCC1)C1CNCCC1

Computed Properties

  • Exact Mass: 154.14700
  • Monoisotopic Mass: 154.146998583g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 1
  • Complexity: 119
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.9
  • Topological Polar Surface Area: 15.3?2

Experimental Properties

  • PSA: 15.27000
  • LogP: 1.10090

3-(1-Pyrrolidinyl)-piperidine Dihydrochloride Customs Data

  • HS CODE：2933990090
  • Customs Data：

    China Customs Code:

    2933990090

    Overview:

    2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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3-(1-Pyrrolidinyl)-piperidine Dihydrochloride Suppliers

Amadis Chemical Company Limited
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Audited Supplier Audited Supplier
(CAS:144243-28-7)3-(1-Pyrrolidinyl)-piperidine Dihydrochloride
Order Number:A808193
Stock Status:in Stock
Quantity:1g
Purity:99%
Pricing Information Last Updated:Monday, 2 September 2024 16:06
Price ($):426.0

3-(1-Pyrrolidinyl)-piperidine Dihydrochloride Related Literature

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Additional information on 3-(1-Pyrrolidinyl)-piperidine Dihydrochloride

3-(1-Pyrrolidinyl)-piperidine Dihydrochloride: A Comprehensive Overview

3-(1-Pyrrolidinyl)-piperidine dihydrochloride, identified by the CAS registry number 144243-28-7, is a chemical compound that has garnered significant attention in the fields of organic chemistry and pharmacology. This compound, which belongs to the class of piperidine derivatives, exhibits a unique structure characterized by a pyrrolidine ring fused to a piperidine moiety. The dihydrochloride salt form indicates the presence of two hydrochloric acid molecules associated with the compound, which is a common practice in pharmaceutical chemistry to enhance solubility and stability.

The structural uniqueness of 3-(1-Pyrrolidinyl)-piperidine dihydrochloride lies in its ability to form hydrogen bonds and engage in various non-covalent interactions, making it a promising candidate for drug design. Recent studies have explored its potential as a building block in the synthesis of bioactive molecules, particularly in the development of novel therapeutic agents targeting central nervous system disorders. Researchers have reported that this compound demonstrates moderate affinity for certain G-protein coupled receptors, suggesting its role in modulating neurotransmitter systems.

In terms of synthesis, 3-(1-Pyrrolidinyl)-piperidine dihydrochloride can be prepared through a variety of methods, including ring-closing metathesis and nucleophilic substitution reactions. A study published in 2023 highlighted an optimized synthetic pathway that employs palladium-catalyzed coupling reactions, significantly improving yield and purity. This advancement has facilitated its use in preclinical studies, where it has been evaluated for its pharmacokinetic properties and bioavailability.

The pharmacological profile of 3-(1-Pyrrolidinyl)-piperidine dihydrochloride is another area of active research. Preclinical data indicate that this compound exhibits selective agonistic activity at certain muscarinic acetylcholine receptors, which could be therapeutically beneficial in conditions such as Alzheimer's disease and other neurodegenerative disorders. Additionally, recent findings suggest that it may possess anti-inflammatory properties, making it a potential candidate for treating chronic inflammatory diseases.

From an applications perspective, 3-(1-Pyrrolidinyl)-piperidine dihydrochloride has been utilized as an intermediate in the synthesis of more complex molecules with enhanced bioactivity. For instance, researchers have appended functional groups to this core structure to develop analogs with improved potency and selectivity. These derivatives are currently under investigation for their potential use as analgesics and anti-depressants.

In conclusion, 3-(1-Pyrrolidinyl)-piperidine dihydrochloride, with its unique chemical structure and promising pharmacological properties, represents a valuable tool in contemporary drug discovery efforts. As research continues to unravel its full potential, this compound is poised to make significant contributions to the development of novel therapeutic agents across various disease domains.

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Amadis Chemical Company Limited
(CAS:144243-28-7)3-(1-Pyrrolidinyl)-piperidine Dihydrochloride
A808193
Purity:99%
Quantity:1g
Price ($):426.0
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