• 1. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 2. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
• 3. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 4. Distinction of trans–cis photoisomers with comparable optical properties in multiple-state photochromic systems – examining a molecule with three azobenzenes via in situ irradiation NMR spectroscopy?
  Jonas Kind,Lukas Kaltschnee,Martin Leyendecker,Christina M. Thiele Chem. Commun., 2016,52, 12506-12509
• 5. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198

• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides
• Solvents and Organic Chemicals Organic Compounds

Compound CAS No. 144043-17-4: (3R)-1-Benzyl-N-Methylpyrrolidin-3-Amine

(3R)-1-Benzyl-N-Methylpyrrolidin-3-Amine, also known by its CAS registry number CAS No. 144043-17-4, is a versatile and biologically active compound that has garnered significant attention in the fields of organic chemistry, pharmacology, and drug discovery. This compound is a chiral derivative of pyrrolidine, a five-membered nitrogen-containing heterocycle, with a benzyl group attached at the 1-position and an N-methyl group at the nitrogen atom. The stereochemistry at the 3-position, designated as (R), plays a crucial role in its pharmacokinetic and pharmacodynamic properties.

The structural uniqueness of (3R)-1-Benzyl-N-Methylpyrrolidin-3-Amine lies in its ability to act as a rigid scaffold for various chemical modifications. This makes it an ideal candidate for exploring novel bioactive molecules. Recent studies have highlighted its potential as a building block in the synthesis of complex natural products and bioactive compounds. For instance, researchers have utilized this compound to construct intricate alkaloid frameworks, demonstrating its utility in total synthesis efforts.

One of the most compelling aspects of CAS No. 144043-17-4 is its role in medicinal chemistry. The compound has been extensively studied for its ability to modulate cellular signaling pathways, particularly those involving G-protein coupled receptors (GPCRs). Preclinical studies have shown that it exhibits potent agonistic activity at certain adrenergic receptors, making it a promising lead compound for the development of drugs targeting cardiovascular and central nervous system disorders.

Moreover, the stereochemistry of (3R)-1-Benzyl-N-Methylpyrrolidin-3-Amine has been shown to significantly influence its pharmacokinetic profile. Studies conducted in animal models reveal that the (R) configuration enhances oral bioavailability and reduces first-pass metabolism, which are critical factors for drug candidates aiming for systemic delivery. These findings underscore the importance of stereochemical control in drug design and optimization.

In terms of synthetic applications, this compound serves as an excellent substrate for various catalytic transformations. Recent advancements in asymmetric catalysis have enabled the efficient synthesis of enantiomerically pure (3R)-1-Benzyl-N-Methylpyrrolidin-3-Amine. For example, organocatalytic approaches using proline-derived catalysts have been employed to achieve high enantioselectivity during the construction of the pyrrolidine ring.

The versatility of CAS No. 144043-17-4 extends beyond medicinal chemistry into materials science. Researchers have explored its use as a chiral template for constructing asymmetric materials, such as liquid crystals and polymer networks. These applications leverage the unique spatial arrangement of the molecule to induce chirality at the macroscopic level.

Looking ahead, the continued exploration of (3R)-1-Benzyl-N-Methylpyrrolidin-3-Amine's biological and chemical properties is expected to yield further insights into its potential applications. Collaborative efforts between chemists, biologists, and pharmacologists are likely to drive innovation in this area, paving the way for novel therapeutic agents and advanced materials.

• 1235437-44-1((3R)-1-benzyl-N,N-dimethylpyrrolidin-3-amine)
• 859213-31-3((S)-1-Benzyl-3-(1-pyrrolidinyl)pyrrolidine)
• 1092294-32-0(1-benzyl-N-(propan-2-yl)pyrrolidin-3-amine)
• 1354019-30-9(((R)-1-Benzyl-pyrrolidin-3-yl)-isopropyl-amine)
• 1354009-82-7(((S)-1-Benzyl-pyrrolidin-3-yl)-isopropyl-amine)
• 1260589-65-8((S)-(+)-3-N,N-Dibenzylaminopyrrolidin)
• 62396-50-3((3S)-1-benzyl-N-ethyl-N-methylpyrrolidin-3-amine)
• 62396-49-0((3R)-1-benzyl-N-ethyl-N-methylpyrrolidin-3-amine)
• 1354009-52-1(Benzyl-methyl-(R)-pyrrolidin-3-yl-amine)
• 64021-80-3(3-Pyrrolidinamine, 1-methyl-N-(phenylmethyl)-)