• 1. Fe3O4@PANI: a magnetic polyaniline nanomaterial for highly efficient and handy enrichment of intact N-glycopeptides??
  Zhizhen Lai,Mo Zhang,Jinyu Zhou,Tianjing Chen,Dan Li,Xuejing Shen,Jia Liu,Jiang Zhou,Zhili Li Analyst, 2021,146, 4261-4267
• 2. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 3. Excitonic channels from bio-inspired templated supramolecular assembly of J-aggregate nanowires?
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• 4. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
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• 5. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinecarboxylic acids and derivatives Piperidinecarboxylic acids

Ethyl 4-(pyridin-4-ylmethyl)piperazine-1-carboxylate: A Comprehensive Overview

Ethyl 4-(pyridin-4-ylmethyl)piperazine-1-carboxylate, with CAS No. 143210-48-4, is a compound of significant interest in the fields of organic chemistry and pharmacology. This compound is characterized by its unique structure, which combines a piperazine ring with a pyridine moiety and an ethoxy carboxylic acid ester group. The piperazine ring is a six-membered saturated ring containing two nitrogen atoms, while the pyridine group introduces aromaticity and potential for hydrogen bonding. The ethoxy carboxylic acid ester group adds to the compound's versatility, making it a valuable building block in various chemical reactions.

Recent studies have highlighted the importance of Ethyl 4-(pyridin-4-ylmethyl)piperazine-1-carboxylate in drug design and development. Its structure allows for easy functionalization, enabling researchers to explore its potential as a precursor for bioactive molecules. For instance, the compound has been utilized in the synthesis of novel antidepressants and neuroprotective agents, where the piperazine ring plays a crucial role in modulating pharmacokinetic properties such as solubility and bioavailability.

The synthesis of Ethyl 4-(pyridin-4-ylmethyl)piperazine-1-carboxylate involves a series of well-established organic reactions. Typically, the process begins with the preparation of piperazine derivatives, followed by alkylation to introduce the pyridine moiety. The final step involves esterification to attach the ethoxy carboxylic acid group. This multi-step synthesis ensures high purity and structural integrity, making it suitable for both academic research and industrial applications.

In terms of applications, Ethyl 4-(pyridin-4-ylmethyl)piperazine-1-carboxylate has found use in materials science as well. Its ability to form stable complexes with metal ions has led to its exploration in the development of coordination polymers and metal-organic frameworks (MOFs). These materials exhibit unique properties such as high surface area and porosity, making them ideal candidates for gas storage and catalysis.

Moreover, recent advancements in green chemistry have prompted researchers to investigate more sustainable methods for synthesizing Ethyl 4-(pyridin-4-ylmethyl)piperazine-1-carboxylate. Techniques such as microwave-assisted synthesis and enzymatic catalysis are being explored to reduce environmental impact while maintaining product quality. These efforts align with global initiatives to promote eco-friendly chemical processes.

The compound's stability under various conditions has also been a focal point of recent research. Studies have demonstrated that Ethyl 4-(pyridin-4-ylmethyl)piperazine-1-carboxylate exhibits excellent thermal stability, making it suitable for high-temperature applications. Additionally, its resistance to hydrolysis under physiological conditions enhances its potential as a drug candidate.

In conclusion, Ethyl 4-(pyridin-4-yLmethyl)piperazine -1 -carbox ylate (CAS No. 143210 -48 -4) is a versatile compound with wide-ranging applications in chemistry and pharmacology. Its unique structure, combined with recent advancements in synthesis and application techniques, positions it as a key player in modern chemical research. As ongoing studies continue to uncover new possibilities, this compound is poised to make significant contributions to both academic and industrial sectors.

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