• 1. An approach to asymmetric synthesis of β-aryl alanines by Pd(0)-catalyzed cross-coupling and cyanate-to-isocyanate rearrangement?
  Piotr Szcze?niak,Sebastian Stecko RSC Adv., 2015,5, 30882-30888
• 2. Aggregation-induced emission leading to two distinct emissive species in the solid-state structure of high-dipole organic chromophores?
  Felix Witte,Philipp Rietsch,Nithiya Nirmalananthan-Budau,Florian Weigert,Jan P. G?tze,Ute Resch-Genger,Siegfried Eigler,Beate Paulus Phys. Chem. Chem. Phys., 2021,23, 17521-17529
• 3. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
• 4. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 5. An investigation of new infrared nonlinear optical material: BaCdSnSe4, and three new related centrosymmetric compounds: Ba2SnSe4, Mg2GeSe4, and Ba2Ge2S6?
  Kui Wu,Zhihua Yang,Shilie Pan Dalton Trans., 2015,44, 19856-19864

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Thiophenes Thiophene carboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Thiophenes Thiophene carboxylic acids and derivatives Thiophene carboxylic acids

Comprehensive Guide to 4-Methylthiophene-2-carboxylic acid (CAS No. 14282-78-1): Properties, Applications, and Industry Insights

4-Methylthiophene-2-carboxylic acid (CAS No. 14282-78-1) is a versatile organic compound widely recognized for its role in pharmaceutical and agrochemical synthesis. This thiophene derivative features a carboxylic acid functional group, making it a valuable intermediate in the production of active pharmaceutical ingredients (APIs) and specialty chemicals. With the increasing demand for heterocyclic compounds in drug discovery, this compound has garnered significant attention from researchers and manufacturers alike.

The molecular structure of 4-Methylthiophene-2-carboxylic acid combines a methyl-substituted thiophene ring with a carboxyl group, offering unique reactivity patterns. Its CAS number 14282-78-1 serves as a universal identifier in chemical databases, ensuring accurate tracking in global supply chains. Recent studies highlight its potential in developing biodegradable polymers and green chemistry applications, aligning with the industry's shift toward sustainable practices.

In pharmaceutical research, 4-Methylthiophene-2-carboxylic acid is frequently explored as a building block for small-molecule drugs. Its structural motif appears in compounds targeting inflammation and metabolic disorders, addressing trending healthcare needs. Analytical techniques like HPLC and NMR spectroscopy are commonly employed to verify its purity, a critical factor given its role in high-value syntheses.

The compound's stability under standard storage conditions (typically room temperature in airtight containers) makes it a practical choice for industrial use. However, users often search for "solubility of 4-Methylthiophene-2-carboxylic acid" or "compatible solvents for CAS 14282-78-1," reflecting practical application concerns. It demonstrates moderate solubility in polar organic solvents like ethanol and dimethyl sulfoxide (DMSO), but limited solubility in water.

Emerging applications in material science have expanded the relevance of this compound. Researchers are investigating its derivatives for organic electronics, particularly in designing conductive polymers for flexible displays—a hot topic in advanced materials. This aligns with frequent search queries about "thiophene-based materials for OLEDs" and "CAS 14282-78-1 in polymer research."

Quality control protocols for 4-Methylthiophene-2-carboxylic acid emphasize chromatographic purity analysis and residual solvent testing. Suppliers often provide technical data sheets addressing common purchaser questions like "Is 4-Methylthiophene-2-carboxylic acid hygroscopic?" (Answer: It shows low hygroscopicity under normal conditions). The compound typically appears as white to off-white crystalline powder with characteristic spectroscopic signatures.

From a regulatory standpoint, proper handling involves standard laboratory precautions despite its non-hazardous classification. Industry forums frequently discuss "scaling up 4-Methylthiophene-2-carboxylic acid synthesis," reflecting growing commercial interest. Recent patent literature reveals innovative routes to improve yield and reduce byproducts in its production.

Environmental considerations are increasingly important, with researchers evaluating biodegradation pathways of thiophene derivatives. Lifecycle assessments of CAS 14282-78-1 indicate favorable environmental profiles compared to halogenated analogs, responding to market demands for eco-friendly chemicals.

The global market for 4-Methylthiophene-2-carboxylic acid shows steady growth, driven by pharmaceutical outsourcing and Asian API manufacturing expansion. Price trends and supply chain dynamics for CAS 14282-78-1 remain common search topics among procurement specialists, highlighting its commercial significance.

Future research directions may explore catalytic modifications of the thiophene ring or novel derivatization techniques to unlock further applications. As synthetic methodologies advance, this compound continues to demonstrate why it remains a staple in modern organic chemistry laboratories worldwide.

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• 406719-77-5(4-Cyanothiophene-2-carboxylic acid)
• 40808-24-0(4,5-Dimethylthiophene-2-carboxylic acid)
• 61854-93-1(2-Thiophenecarboxylic acid, 4-(mercaptomethyl)-)
• 89639-74-7(3,4-Dimethylthiophene-2-carboxylic acid)
• 23806-24-8(3-Methylthiophene-2-carboxylic acid)
• 28686-90-0(Methyl 4-methylthiophene-2-carboxylate)
• 62404-08-4(2-Thiophenecarboxylic acid, 5-methyl-4-phenyl-)
• 54796-49-5(4-(methoxymethyl)thiophene-2-carboxylic acid)