• 1. An integrated cathode and solid electrolyte via in situ polymerization with significantly reduced interface resistance?
  Jialiang Yuan,Ran Dong,Yuan Li,Yang Liu,Zhuo Zheng,Yuxia Liu,Yan Sun,Benhe Zhong,Zhenguo Wu,Xiaodong Guo Chem. Commun., 2021,57, 13004-13007
• 2. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 3. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
• 4. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 5. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles

Comprehensive Overview of [1-(2-fluoroethyl)-1H-pyrazol-4-yl]methanol (CAS No. 1427023-85-5)

[1-(2-fluoroethyl)-1H-pyrazol-4-yl]methanol (CAS No. 1427023-85-5) is a fluorinated pyrazole derivative that has garnered significant attention in pharmaceutical and agrochemical research. This compound, characterized by its unique fluoroethyl and hydroxymethyl functional groups, serves as a versatile intermediate in the synthesis of biologically active molecules. Its molecular structure, combining a pyrazole core with a fluorinated side chain, makes it particularly valuable for modulating pharmacokinetic properties such as metabolic stability and membrane permeability.

In recent years, the demand for fluorinated compounds like [1-(2-fluoroethyl)-1H-pyrazol-4-yl]methanol has surged due to their applications in drug discovery. Researchers frequently search for terms such as "fluorinated pyrazole synthesis" or "CAS 1427023-85-5 applications", reflecting the compound's relevance in medicinal chemistry. The fluoroethyl group is known to enhance binding affinity to target proteins, while the hydroxymethyl moiety offers a handle for further derivatization, making this compound a cornerstone in fragment-based drug design.

The compound's stability under physiological conditions is another area of interest. Studies have shown that [1-(2-fluoroethyl)-1H-pyrazol-4-yl]methanol exhibits remarkable resistance to enzymatic degradation, a trait highly sought after in the development of long-acting therapeutics. This property aligns with current trends in sustainable chemistry and green synthesis, as it reduces the need for frequent dosing and minimizes waste. Queries like "biostable fluorinated intermediates" or "eco-friendly pyrazole derivatives" often lead to discussions about this compound's potential.

From a synthetic perspective, CAS No. 1427023-85-5 is frequently explored in cross-coupling reactions and nucleophilic substitutions. Its compatibility with palladium-catalyzed reactions and microwave-assisted synthesis has been documented, catering to the growing interest in high-throughput methodologies. Laboratories focusing on automated synthesis platforms or AI-driven retrosynthesis tools often reference this compound as a test case due to its balanced reactivity and selectivity.

Beyond pharmaceuticals, [1-(2-fluoroethyl)-1H-pyrazol-4-yl]methanol finds utility in material science, particularly in the design of fluorinated polymers with tailored dielectric properties. This application resonates with searches for "advanced electronic materials" and "high-performance fluoropolymers", highlighting the compound's interdisciplinary appeal. The pyrazole ring contributes to thermal stability, while the fluorine atoms impart hydrophobicity—features critical for next-generation coatings and insulating materials.

Analytical characterization of this compound typically involves NMR spectroscopy (notably 19F-NMR for the fluoroethyl group) and mass spectrometry, techniques frequently queried alongside CAS 1427023-85-5 in academic databases. The distinct chemical shift of the fluorinated moiety serves as a diagnostic marker, simplifying purity assessment—a key concern for researchers troubleshooting scale-up challenges or regulatory compliance in API manufacturing.

As the scientific community increasingly prioritizes structural diversity in compound libraries, [1-(2-fluoroethyl)-1H-pyrazol-4-yl]methanol stands out as a scaffold capable of delivering both three-dimensional complexity and vectorial functionality. Its adoption in fragment-based screening campaigns and proteolysis-targeting chimera (PROTAC) designs underscores its strategic value. Recent patent analyses reveal a steady rise in filings incorporating this motif, particularly for kinase inhibitors and GPCR modulators—topics dominating current drug discovery forums.

Environmental and toxicological profiling of CAS 1427023-85-5 remains an active area of investigation, with particular emphasis on its biodegradation pathways and ecotoxicological impact. These studies address pressing queries about "green metrics for fluorinated APIs" and "benign-by-design principles", aligning with global initiatives for sustainable molecular design. Preliminary data suggest that the compound's aliphatic fluorine exhibits lower persistence compared to aromatic fluorides, a nuance increasingly relevant in environmental risk assessments.

In summary, [1-(2-fluoroethyl)-1H-pyrazol-4-yl]methanol (CAS No. 1427023-85-5) represents a multifaceted building block whose utility spans from precision medicine to advanced materials engineering. Its structural features address contemporary challenges in molecular optimization, while its synthetic accessibility meets the demands of modern high-efficiency chemistry. As research continues to unravel new applications, this compound is poised to remain at the forefront of innovation-driven chemistry.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)