• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 3. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 4. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
• 5. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788

Pyridine, 3,5-dibromo-2-ethyl- (CAS No. 142337-93-7): A Comprehensive Overview in Modern Chemical Research

Pyridine, 3,5-dibromo-2-ethyl-, identified by its Chemical Abstracts Service (CAS) number CAS No. 142337-93-7, is a significant compound in the realm of organic chemistry and pharmaceutical research. This heterocyclic aromatic amine derivative has garnered attention due to its unique structural properties and versatile applications in synthetic chemistry and drug development.

The molecular structure of Pyridine, 3,5-dibromo-2-ethyl- consists of a pyridine ring substituted with bromine atoms at the 3rd and 5th positions and an ethyl group at the 2nd position. This specific arrangement imparts distinct reactivity and functionalization possibilities, making it a valuable intermediate in the synthesis of more complex molecules. The presence of bromine atoms enhances its utility in cross-coupling reactions, which are pivotal in constructing intricate molecular frameworks.

In recent years, the compound has found relevance in the development of novel pharmaceuticals. Its brominated pyridine core serves as a scaffold for designing bioactive molecules with potential therapeutic applications. Researchers have leveraged its reactivity to develop inhibitors targeting various biological pathways. For instance, studies have explored its role in creating kinase inhibitors, which are crucial in treating cancers and inflammatory diseases. The bromine substituents facilitate palladium-catalyzed cross-coupling reactions, enabling the introduction of diverse functional groups and enhancing binding affinity to biological targets.

The ethyl group at the 2-position adds another layer of versatility to Pyridine, 3,5-dibromo-2-ethyl-. It can be further modified through various chemical transformations, such as alkylation, acylation, or oxidation, to produce derivatives with tailored properties. These derivatives have been investigated for their potential as antimicrobial agents and antiviral compounds. The ability to modify the pyridine ring while retaining its core structure makes it an attractive candidate for medicinal chemists seeking to optimize drug-like properties.

Advances in computational chemistry have also contributed to the understanding of Pyridine, 3,5-dibromo-2-ethyl-. Molecular modeling studies have revealed insights into its interactions with biological receptors, aiding in the rational design of more effective drugs. These studies often involve predicting binding affinities and identifying key pharmacophoric elements within the molecule. The computational approach complements experimental efforts by providing a rapid screening platform for virtual ligand design.

The synthesis of Pyridine, 3,5-dibromo-2-ethyl- is another area of active research. Efficient synthetic routes are essential for large-scale production and cost-effective drug development. Recent methodologies have focused on greener and more sustainable approaches, minimizing waste and reducing environmental impact. Catalytic processes and flow chemistry techniques have been explored to enhance yield and purity while maintaining scalability.

In conclusion, Pyridine, 3,5-dibromo-2-ethyl- (CAS No. 142337-93-7) represents a fascinating compound with broad applications in chemical synthesis and pharmaceutical research. Its unique structural features and reactivity make it a valuable building block for developing novel bioactive molecules. As research continues to evolve, this compound is likely to play an increasingly important role in addressing complex medical challenges through innovative chemical solutions.

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