• 1. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
• 2. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 3. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 4. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 5. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Aralkylamines
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Aralkylamines

Introduction to 1-5-(propan-2-yl)-1H-1,2,4-triazol-3-ylethan-1-amine hydrochloride (CAS No. 1423034-03-0)

1-5-(propan-2-yl)-1H-1,2,4-triazol-3-ylethan-1-amine hydrochloride is a specialized chemical compound that has garnered significant attention in the field of pharmaceutical research and development. This compound, identified by its CAS number 1423034-03-0, belongs to a class of heterocyclic amines that exhibit promising biological activities. The structural framework of this molecule incorporates a triazole ring, which is a key pharmacophore in many bioactive agents, alongside an amine functional group and an alkyl chain that contributes to its solubility and metabolic stability.

The hydrochloride salt form of this compound enhances its solubility in aqueous solutions, making it more suitable for formulation in drug delivery systems and biological assays. The presence of the propan-2-yl substituent at the 5-position of the triazole ring introduces steric and electronic modifications that can influence the compound's interaction with biological targets. This feature has made it a subject of interest for medicinal chemists exploring novel therapeutic agents.

Recent advancements in computational chemistry and molecular modeling have enabled researchers to predict the binding affinity and pharmacokinetic properties of 1-5-(propan-2-yl)-1H-1,2,4-triazol-3-ylethan-1-amine hydrochloride with greater accuracy. Studies have suggested that the compound may exhibit inhibitory activity against certain enzymes and receptors implicated in inflammatory and infectious diseases. The triazole moiety, known for its stability and ability to engage in hydrogen bonding, is particularly valuable in designing molecules with enhanced binding interactions.

In vitro studies have demonstrated that derivatives of this compound show potential as scaffolds for developing drugs targeting bacterial infections. The alkyl chain and amine group contribute to favorable pharmacokinetic profiles, including improved bioavailability and reduced toxicity. Researchers are exploring synthetic modifications to optimize these properties while maintaining or enhancing biological activity. The hydrochloride salt form also facilitates easier handling and storage, which is crucial for industrial-scale production.

The pharmaceutical industry has been increasingly interested in heterocyclic compounds due to their diverse biological activities. 1H-1,2,4-triazole derivatives are particularly noteworthy for their role in antimicrobial, antiviral, and anti-inflammatory applications. The structural versatility of this class allows for the design of molecules with tailored properties to address specific therapeutic needs. For instance, modifications at the 3-position of the triazole ring can alter the compound's electronic distribution, influencing its reactivity and binding mode.

Current research is focused on understanding the mechanism of action of 1-propanolamine derivatives such as this one. By elucidating how these compounds interact with biological targets at the molecular level, scientists can refine their structures to improve efficacy and reduce side effects. Advances in crystallography and spectroscopy techniques have provided insights into the binding modes of similar triazole-based compounds, guiding the design of more potent derivatives.

The synthesis of 5-(propan-2-yloxy)-3-aminoethylidene hydrazine hydrochloride, a related compound, has been reported as a key intermediate in producing more complex derivatives. This underscores the importance of developing efficient synthetic routes for these molecules. Industrial chemists are leveraging green chemistry principles to minimize waste and improve yields during production, ensuring sustainable practices align with regulatory requirements.

The potential applications of 1423034-03-0 extend beyond infectious diseases; it may also be relevant in treating chronic inflammatory conditions where modulation of enzyme activity is necessary. For example, studies suggest that triazole derivatives can inhibit cyclooxygenase (COX) enzymes involved in prostaglandin synthesis. Such inhibition could lead to reduced inflammation without the gastrointestinal side effects associated with non-selective COX inhibitors.

Regulatory agencies have stringent guidelines for evaluating new drug candidates like this one before they can enter clinical trials. Preclinical studies focus on assessing toxicity profiles, pharmacokinetic behavior, and potential interactions with other drugs. The hydrochloride salt form simplifies dosing calculations due to its predictable solubility characteristics across different pH ranges.

Collaborations between academic institutions and pharmaceutical companies are accelerating the development pipeline for novel heterocyclic compounds like 1H-(3-aminoethylidene)-5-propanoylhydrazine hydrochloride (CAS No: 1423034). These partnerships enable researchers to combine expertise in synthetic chemistry with computational biology to identify promising candidates more rapidly than traditional methods alone would allow.

The future directions for research on this compound include exploring its potential as an antifungal agent or as part of combination therapies targeting resistant bacterial strains. By understanding how it interacts with cellular machinery at both biochemical and genetic levels through techniques such as CRISPR-Cas9 gene editing assays or high-throughput screening platforms containing *Caenorhabditis elegans* models (nematodes), scientists can uncover new therapeutic applications.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)