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Comprehensive Overview of 2-(4-amino-5-methyl-1H-pyrazol-1-yl)ethan-1-ol dihydrochloride (CAS No. 1423033-18-4)

2-(4-amino-5-methyl-1H-pyrazol-1-yl)ethan-1-ol dihydrochloride (CAS No. 1423033-18-4) is a specialized chemical compound gaining attention in pharmaceutical and biochemical research. This compound, characterized by its pyrazole core and ethanolamine side chain, is widely studied for its potential applications in drug discovery and medicinal chemistry. Its unique structure, featuring an amino group and a hydroxyl functionality, makes it a versatile intermediate for synthesizing biologically active molecules.

Researchers are particularly interested in 2-(4-amino-5-methyl-1H-pyrazol-1-yl)ethan-1-ol dihydrochloride due to its role in modulating enzyme activity and receptor interactions. The compound's dihydrochloride salt form enhances its solubility, making it suitable for in vitro and in vivo studies. Recent publications highlight its utility in developing kinase inhibitors and anti-inflammatory agents, aligning with the growing demand for targeted therapies in oncology and autoimmune diseases.

The synthesis of CAS No. 1423033-18-4 involves multi-step organic reactions, including cyclization and N-alkylation processes. Analytical techniques such as HPLC, NMR, and mass spectrometry are employed to ensure high purity (>98%), a critical factor for reproducible experimental results. This level of quality control addresses the increasing focus on research reproducibility—a hot topic in scientific communities.

From an industrial perspective, 2-(4-amino-5-methyl-1H-pyrazol-1-yl)ethan-1-ol dihydrochloride is manufactured under strict GMP guidelines to meet the needs of contract research organizations (CROs) and pharmaceutical companies. Its stability under ambient conditions and compatibility with common solvents like DMSO and water further boost its adoption in high-throughput screening platforms.

Emerging trends in AI-driven drug discovery have also spotlighted this compound. Machine learning models trained on pyrazole derivatives frequently reference CAS 1423033-18-4 as a scaffold for virtual screening. This intersection of computational chemistry and experimental validation underscores its relevance in modern precision medicine initiatives.

Environmental and safety profiles of 2-(4-amino-5-methyl-1H-pyrazol-1-yl)ethan-1-ol dihydrochloride are rigorously documented. While not classified as hazardous, standard laboratory precautions—such as using PPE and proper ventilation—are recommended during handling. These protocols align with global green chemistry principles, another trending focus area.

In summary, CAS No. 1423033-18-4 represents a promising building block in life sciences. Its dual functionality, stability, and compatibility with cutting-edge technologies position it at the forefront of small-molecule research. As the scientific community continues to explore its potential, this compound is poised to play a pivotal role in advancing therapeutic innovations.

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