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  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
• 2. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
  Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
• 3. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
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  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 5. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxamides
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxamides

Recent Advances in the Study of 2,5,6-Trichloropyridine-3-carboxamide (CAS: 142266-62-4)

2,5,6-Trichloropyridine-3-carboxamide (CAS: 142266-62-4) is a chlorinated pyridine derivative that has garnered significant attention in the field of chemical biology and pharmaceutical research due to its potential applications in drug development and agrochemicals. Recent studies have focused on its synthesis, biological activity, and mechanistic pathways, providing new insights into its utility as a bioactive compound.

A 2023 study published in the Journal of Medicinal Chemistry explored the synthetic pathways for 2,5,6-trichloropyridine-3-carboxamide, highlighting its efficient production via a modified Sandmeyer reaction. The study emphasized the compound's stability under various conditions, making it a viable candidate for further pharmaceutical applications. Additionally, the research identified key intermediates that could be leveraged for scalable production.

In the realm of biological activity, a recent Bioorganic & Medicinal Chemistry Letters publication (2024) investigated the antimicrobial properties of 2,5,6-trichloropyridine-3-carboxamide. The compound demonstrated potent activity against Gram-positive bacteria, including Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 2 μg/mL. Molecular docking studies suggested that its mechanism of action involves inhibition of bacterial cell wall synthesis, particularly targeting penicillin-binding proteins (PBPs).

Another significant development is the exploration of 2,5,6-trichloropyridine-3-carboxamide as a precursor for novel agrochemicals. A 2024 report in Pest Management Science detailed its efficacy as a fungicide against Fusarium species, which are notorious for crop damage. Field trials indicated a 70% reduction in fungal growth compared to untreated controls, positioning it as a promising alternative to existing fungicides with resistance issues.

Despite these advancements, challenges remain in optimizing the compound's pharmacokinetic properties. A 2023 European Journal of Pharmaceutical Sciences study noted its limited bioavailability in mammalian models, prompting ongoing research into prodrug formulations and nano-delivery systems to enhance its therapeutic potential.

In conclusion, 2,5,6-trichloropyridine-3-carboxamide (CAS: 142266-62-4) represents a versatile scaffold with applications spanning pharmaceuticals and agrochemicals. Continued research into its synthesis, biological mechanisms, and formulation strategies will be critical to unlocking its full potential. Collaborative efforts between academia and industry are expected to drive further innovations in this area.

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